EKS-MUM-00468

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00468

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	312.6	5.9E-93	4	280	277

Status

Reviewed

Ensembl Protein

ENSMUSP00000129214

UniProt Accession

Q3V129; Q2VP87; Q32LZ6; Q8BLS0; Q8C8Z5; Q9D4H6;

Protein Name

Serine/threonine-protein kinase ULK4

Protein Synonyms/Alias

Unc-51-like kinase 4;

Gene Name

Ulk4

Gene Synonyms/Alias

Ulk4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000040936	ENSMUSP00000057960	ENSMUST00000051479
ENSMUSG00000040936	ENSMUSP00000054833	ENSMUST00000051565
ENSMUSG00000040936	ENSMUSP00000131488	ENSMUST00000170237
ENSMUSG00000040936	ENSMUSP00000131342	ENSMUST00000171923
ENSMUSG00000040936	ENSMUSP00000129214	ENSMUST00000171061

Organism

Mus musculus

Functional Description

Protein Length

910

Protein Sequence
(FASTA)

MENFVLYEEI GRGSRTVVYK GRRKGTINFV AILCTEKCKR PEITNWVRLT HEIKHKNIVT 60

FHEWYETSNH LWLVVELCTG GSLETVIAQD ENLPEDVVRE FGVDLVTGLH HLHRLGILFC 120

DLSPGKILLE GPGTLKFSNF CLAKVAGESL EEFFALVAAE EGGGDSGENA LKKSMKTRVR 180

GSLIYAAPEI VKGTEFSVTS DLWSLGCLLY EMFSGKPPFF SETVSELVEK ILYEDPLPPI 240

PKDSSFPKAS SDFLNLLDGL LQKDPQKRFS WEGVLQHPFW KDALRGEDSG WASEDSPFSR 300

NVMECSGPHD SRELLQSPKN GQAKGQKAAH RLSQSFRLEN PTELRPKSIM GGQLNESIFL 360

LSSRPTPRTS AMVELNPGEG EDPSSPQKTS PLSKMTSGHL SQGALESQMR ELIYTDSDLV 420

ITPIIDNPKI MKQPAIKFDP KILHLPAYSV EKLLVLKDQD WNDFLQQVCS QIDSSEKSTG 480

ALRAKLNLLC YLCVVATHKE VATRLLHSPL FQLLIQHLRI APNWDIRSKV ARVVGMLALH 540

TTELQENVPV IEAITLLTEL IRENFRSGKL KQCLLPTLGQ LLYLVATQEE KNQHSRDCWA 600

VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQA QGFTTGEIGP VLWHLFRHST 660

VDALRITAIS ALCRITRQSP TAFQNVIEKV GLNAVISSLA SAICKVQQYM LTLFTAMLSC 720

GIHLQRLIQE KDFVSTVIRL LDSPSTPIRA KAFLVLLYIL IHNRDMLLLS CQARLVMYIE 780

RDSRKTSPGK EQQSGNEYLA RCLDLLIQHM VQEPPRILGD ILNALANVSG RKHPSTVQGK 840

QLKMCLPMMP VVLHLVMSQV FRPQVVTEEF LFSYGTILVS SRSHVWPAPL PWLQHGCEKG 900

GIERLSGICL 910

Nucleotide Sequence
(FASTA)

ATGGAAAACT TCGTCTTGTA TGAGGAGATT GGCAGAGGAA GCAGGACTGT CGTATATAAG 60

GGGCGCCGGA AAGGAACCAT CAACTTTGTA GCCATCCTTT GTACTGAGAA GTGCAAACGG 120

CCTGAAATAA CCAACTGGGT CCGCCTCACC CATGAAATAA AACACAAGAA CATTGTAACT 180

TTTCACGAGT GGTACGAGAC CAGCAATCAT CTCTGGTTGG TGGTGGAGCT TTGCACAGGT 240

GGTTCTCTAG AAACCGTGAT TGCTCAGGAC GAAAACCTCC CAGAAGATGT CGTGAGAGAG 300

TTTGGGGTGG ACCTGGTCAC AGGGCTGCAC CATCTCCACA GGCTGGGCAT CCTCTTTTGT 360

GACCTTTCTC CTGGGAAGAT TCTCTTGGAA GGGCCTGGAA CACTGAAGTT CAGCAATTTC 420

TGCCTGGCCA AGGTGGCAGG GGAGAGTCTG GAGGAGTTCT TTGCTTTGGT GGCAGCAGAA 480

GAAGGAGGTG GTGACAGTGG AGAGAACGCA CTGAAGAAAA GCATGAAGAC CCGAGTCAGA 540

GGCTCTCTGA TCTATGCGGC TCCGGAAATC GTGAAGGGGA CTGAATTCTC CGTTACCAGT 600

GACCTCTGGT CTTTGGGCTG TCTACTTTAT GAAATGTTTT CAGGGAAACC CCCATTCTTC 660

TCAGAAACGG TGTCAGAACT CGTTGAGAAG ATTCTGTATG AAGACCCATT GCCACCAATC 720

CCAAAAGACT CTTCATTCCC CAAAGCATCC TCAGATTTCC TTAACTTGCT GGACGGATTG 780

CTGCAGAAGG ATCCTCAGAA AAGATTCTCC TGGGAGGGAG TTCTGCAGCA CCCATTCTGG 840

AAAGACGCCC TGCGGGGAGA AGACTCAGGC TGGGCCTCCG AGGACTCCCC CTTCAGCAGA 900

AACGTCATGG AGTGTTCTGG ACCGCATGAT TCCAGAGAGC TTTTGCAGAG CCCTAAGAAT 960

GGACAAGCCA AAGGGCAGAA GGCAGCTCAT CGGCTCAGCC AGTCTTTCAG GCTAGAAAAC 1020

CCAACTGAGC TGAGGCCCAA GAGCATCATG GGAGGCCAGC TGAATGAATC CATATTTCTC 1080

CTCAGTTCAC GGCCCACTCC AAGGACTAGT GCCATGGTGG AATTAAATCC TGGTGAGGGT 1140

GAGGACCCCA GCTCACCTCA GAAGACTTCT CCCTTATCCA AGATGACAAG CGGGCACCTG 1200

AGCCAGGGGG CCCTGGAGTC CCAGATGAGA GAGCTGATCT ACACGGACTC GGATCTTGTG 1260

ATCACCCCAA TTATAGACAA TCCGAAGATA ATGAAACAAC CTGCAATCAA GTTTGATCCA 1320

AAAATCTTGC ACCTACCAGC ATATTCTGTG GAGAAGTTGC TGGTCCTCAA GGACCAAGAC 1380

TGGAATGACT TCCTGCAGCA GGTGTGCTCC CAGATCGACT CCAGCGAGAA GAGCACAGGG 1440

GCGCTGCGGG CCAAGCTGAA CCTCCTGTGC TACCTGTGTG TGGTGGCCAC GCACAAGGAG 1500

GTGGCCACCA GGCTGCTTCA CTCCCCGCTG TTCCAGTTGC TAATCCAGCA CCTGCGGATA 1560

GCTCCTAACT GGGATATACG GTCCAAGGTT GCTCGGGTGG TCGGCATGCT GGCCTTGCAC 1620

ACAACCGAAC TTCAGGAAAA TGTGCCTGTT ATCGAGGCGA TCACACTCTT AACTGAATTA 1680

ATCCGGGAAA ATTTCAGGAG TGGCAAACTG AAGCAGTGCC TCCTGCCCAC CCTTGGACAG 1740

CTTCTCTACC TTGTAGCCAC CCAGGAAGAA AAAAATCAGC ACTCCAGGGA TTGCTGGGCC 1800

GTCCCCCTGG CTGCATACAC TGTGCTTATG AGGTGCCTCC GGGAAGGGGA GGAACGGGTT 1860

GTCAATCACA TGGCTGCGAA GATTATCGAG AATGTTTGCA CGACGTTTTC TGCCCAGGCG 1920

CAGGGCTTCA CAACCGGGGA GATTGGGCCT GTCCTGTGGC ACCTCTTTAG ACACTCCACC 1980

GTGGACGCCC TGCGGATAAC CGCGATATCG GCCCTGTGCA GGATCACACG GCAGTCTCCC 2040

ACCGCCTTCC AGAATGTCAT CGAGAAGGTG GGTCTCAATG CAGTCATCAG CTCCCTGGCC 2100

TCTGCCATCT GCAAAGTGCA GCAGTACATG CTGACCCTGT TCACAGCCAT GCTGTCCTGT 2160

GGGATTCATC TCCAGCGGCT GATCCAAGAG AAGGACTTCG TCTCTACAGT CATCCGCTTA 2220

CTTGATAGTC CGTCCACTCC CATCAGAGCC AAAGCCTTCC TGGTGCTGCT GTACATCTTG 2280

ATTCATAACC GGGACATGCT GCTGCTGAGC TGCCAAGCCA GGCTGGTGAT GTACATCGAG 2340

AGAGACAGCA GAAAGACCTC CCCAGGCAAG GAGCAGCAGA GTGGGAATGA GTACCTGGCC 2400

AGGTGCCTGG ACCTCCTCAT CCAGCACATG GTACAGGAGC CACCTCGGAT CCTAGGCGAC 2460

ATTCTCAACG CCCTGGCAAA CGTGTCCGGC CGGAAGCACC CATCCACGGT CCAGGGGAAG 2520

CAGCTGAAGA TGTGTCTCCC CATGATGCCT GTGGTGCTTC ACCTGGTGAT GTCACAGGTA 2580

TTTCGACCTC AAGTTGTGAC AGAAGAGTTT CTCTTCAGCT ACGGAACTAT TCTTGTGAGT 2640

AGCAGGAGTC ATGTGTGGCC AGCACCACTG CCATGGCTGC AGCACGGGTG CGAGAAGGGA 2700

GGAATTGAAA GGCTCAGTGG TATTTGTTTG TAG 2733

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ++l+eeiG+Gs++vvykgr rk t+++vAi+++ek+k+    +++++++++++e+kh+ni

Q: 4     FVLYEEIGRGSRTVVYKGR-RKGTINFVAILCTEKCKR----PEITNWVRLTHEIKHKNI  58

         7899***************.*****************9....******************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         v++++++ets++++lv+e+c+gg+L+++++q+++L+ed+vref ++l+++l++Lh+++i+

Q: 59    VTFHEWYETSNHLWLVVELCTGGSLETVIAQDENLPEDVVREFGVDLVTGLHHLHRLGIL  118

         ************************************************************

S: 121   hrDlkPqniLlsyadakkelkkvtlkladFglarvlkee.....................  159

         ++Dl+P +iLl+        +++tlk+++F+la+v+ e+

Q: 119   FCDLSPGKILLE--------GPGTLKFSNFCLAKVAGESleeffalvaaeegggdsgena  170

         ************........9***************************************

S: 160   ...smaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyellvGkpPfaaesiseLvek  216

            sm+++++Gs++Y+aPE+vk +++++++DlWS+G++lye+++GkpPf++e++seLvek

Q: 171   lkkSMKTRVRGSLIYAAPEIVKGTEFSVTSDLWSLGCLLYEMFSGKPPFFSETVSELVEK  230

         ************************************************************

S: 217   i.ekndvleppipke.....isselkdllqsLLqrdpkkRisfeelfahpfl  262

         i +++++  ppipk+     +ss++ +ll++LLq+dp+kR+s+e +++hpf+

Q: 231   IlYEDPL--PPIPKDssfpkASSDFLNLLDGLLQKDPQKRFSWEGVLQHPFW  280

         *888888..99999888999******************************98

Domain Sequence
(FASTA)

FVLYEEIGRG SRTVVYKGRR KGTINFVAIL CTEKCKRPEI TNWVRLTHEI KHKNIVTFHE 60

WYETSNHLWL VVELCTGGSL ETVIAQDENL PEDVVREFGV DLVTGLHHLH RLGILFCDLS 120

PGKILLEGPG TLKFSNFCLA KVAGESLEEF FALVAAEEGG GDSGENALKK SMKTRVRGSL 180

IYAAPEIVKG TEFSVTSDLW SLGCLLYEMF SGKPPFFSET VSELVEKILY EDPLPPIPKD 240

SSFPKASSDF LNLLDGLLQK DPQKRFSWEG VLQHPFW 277

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0060271	; P:cilium morphogenesis
GO:0003351	; P:epithelial cilium movement
GO:0021591	; P:ventricular system development

KEGG

mmu:209012

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013