EKS-MUM-00098
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00098
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/TSSK412.12.6E-12312272261
StatusReviewed
Ensembl ProteinENSMUSP00000040302
UniProt AccessionQ61241; Q80YU1;
Protein NameTestis-specific serine/threonine-protein kinase 1
Protein Synonyms/Alias TSK-1; TSK1; TSSK-1; Testis-specific kinase 1; Serine/threonine-protein kinase 22A;
Gene NameTssk1b
Gene Synonyms/Alias Tssk1b; Stk22a, Tssk1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000041566ENSMUSP00000040302ENSMUST00000046937
OrganismMus musculus
Functional DescriptionTestis-specific serine/threonine-protein kinase requiredduring spermatid development. Phosphorylates 'Ser-281' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.
Protein Length365
Protein Sequence
(FASTA)
MDDAAVLKRR GYIMGINLGE GSYAKVKSAY SERLKFNVAV KIIDRKKAPS DFLEKFLPRE 60
IEILAMLNHR SIVKTYEIFE TSDGKVYIVM ELGVQGDLLE FIKTRGALQE DDARKKFHQL 120
SSAIKYCHDL DVVHRDLKCE NLLLDKDFNI KLSDFGFSKR CLRDDSGRLI LSKTFCGSAA 180
YAAPEVLQGI PYQPKVYDIW SLGVILYIMV CGSMPYDDSN IKKMLRIQKE HRVNFPRSKH 240
LTGECKDLIY RMLQPDVNRR LHIDEILNHC WVQPKARGLS SGAINKEGES SRATEPSWIP 300
EPGADKKSAT KLEPREEARS EARSESKPQE DTLQVVRQSE NVGLSSELNR DTEEGHPQQP 360
SETHT 365
Nucleotide Sequence
(FASTA)
ATGGATGACG CTGCCGTCCT CAAGCGACGA GGCTACATCA TGGGGATAAA CTTGGGAGAG 60
GGCTCATATG CCAAAGTCAA ATCCGCTTAC TCTGAGCGCC TAAAGTTCAA CGTGGCGGTC 120
AAGATCATCG ATCGCAAGAA AGCCCCCTCA GACTTCCTGG AGAAATTCCT TCCCCGGGAG 180
ATTGAGATTC TGGCCATGCT AAACCACCGC TCTATTGTCA AGACCTATGA GATCTTTGAG 240
ACATCAGATG GCAAGGTCTA CATTGTCATG GAGCTTGGGG TCCAGGGTGA CCTCCTCGAG 300
TTCATCAAAA CCAGAGGAGC CCTGCAAGAG GATGATGCTC GAAAGAAGTT CCACCAGCTC 360
TCCTCGGCCA TCAAGTACTG CCACGACCTG GATGTCGTCC ACCGAGACCT CAAATGTGAG 420
AACCTTCTGC TTGACAAGGA CTTCAACATC AAACTGTCTG ACTTCGGCTT CTCCAAGCGC 480
TGCTTGCGGG ATGATAGTGG TCGACTGATA TTAAGCAAGA CCTTCTGTGG GTCAGCAGCT 540
TATGCGGCCC CCGAGGTGCT GCAGGGCATC CCCTACCAGC CCAAGGTGTA TGACATCTGG 600
AGCCTGGGTG TGATTCTCTA CATCATGGTC TGTGGCTCCA TGCCCTACGA TGACTCCAAC 660
ATCAAAAAGA TGCTGCGCAT CCAGAAGGAG CACCGTGTCA ACTTTCCACG CTCTAAACAC 720
CTGACTGGTG AGTGCAAGGA CCTCATCTAC AGAATGTTAC AGCCAGATGT CAACCGCCGG 780
CTGCACATCG ATGAGATCCT TAACCACTGC TGGGTGCAGC CCAAGGCACG AGGTCTGTCC 840
TCTGGAGCCA TCAACAAGGA GGGGGAAAGC TCCCGGGCCA CTGAGCCCTC ATGGATCCCT 900
GAACCTGGTG CTGATAAGAA GTCTGCCACC AAGTTGGAGC CTAGGGAAGA GGCACGATCT 960
GAGGCCCGGT CTGAGTCAAA ACCCCAGGAA GATACTTTGC AGGTGGTCAG GCAGTCAGAG 1020
AACGTGGGCC TCAGCAGCGA ACTGAACAGG GACACAGAGG AAGGGCACCC CCAACAGCCT 1080
TCAGAGACAC ATACTTAG 1098
Domain Profile
S: 1     lklgkkiGeGsyskvkeaysekkklkvavkiidkkkapedyvkkFlPReleilktlkhkn  60
         + +g ++GeGsy+kvk+ayse+ k++vavkiid+kkap+d+++kFlPRe+eil++l+h++
Q: 12    YIMGINLGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLNHRS  71
         67899*******************************************************
S: 61    ivklyeiietsd.kiylvlelaaqgdllelikesgaleeeearklfsqlvsavkylhsld  119
         ivk+yei+etsd k+y+v+el+ qgdlle+ik++gal+e++ark f+ql+sa+ky+h+ld
Q: 72    IVKTYEIFETSDgKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQLSSAIKYCHDLD  131
         ************************************************************
S: 120   ivhRDlkcenilldkkenvklsDFgFakkvkr...skselsktfCGsaaYaaPevlrgik  176
         +vhRDlkcen+lldk++n+klsDFgF+k++ r   ++  lsktfCGsaaYaaPevl+gi+
Q: 132   VVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRddsGRLILSKTFCGSAAYAAPEVLQGIP  191
         *******************************9998999**********************
S: 177   ydpklsDvWslGvilyvmvvgklPfddsdikkllrsqkkrkvkfpksltlseeckdlile  236
         y+pk++D+WslGvily+mv+g++P+dds+ikk+lr+qk+++v+fp+s++l+ eckdli++
Q: 192   YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYR  251
         ************************************************************
S: 237   llqldakkRltikevlessWl  257
         +lq+d+++Rl+i+e+l+++W+
Q: 252   MLQPDVNRRLHIDEILNHCWV  272
         ********************6
Domain Sequence
(FASTA)
YIMGINLGEG SYAKVKSAYS ERLKFNVAVK IIDRKKAPSD FLEKFLPREI EILAMLNHRS 60
IVKTYEIFET SDGKVYIVME LGVQGDLLEF IKTRGALQED DARKKFHQLS SAIKYCHDLD 120
VVHRDLKCEN LLLDKDFNIK LSDFGFSKRC LRDDSGRLIL SKTFCGSAAY AAPEVLQGIP 180
YQPKVYDIWS LGVILYIMVC GSMPYDDSNI KKMLRIQKEH RVNFPRSKHL TGECKDLIYR 240
MLQPDVNRRL HIDEILNHCW V 261
KeywordATP-binding; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Developmental protein; Differentiation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00089
EKS-ANC-00087
EKS-BOT-00099
EKS-CAE-00086
EKS-CAJ-00100
EKS-CAF-00101
EKS-CAP-00096
EKS-CII-00044
EKS-CIS-00113
EKS-DRM-00047
EKS-EQC-00095
EKS-FEC-00094
EKS-GAA-00118
EKS-GOG-00098
EKS-HOS-00101
EKS-ICT-00091
EKS-LOA-00094
EKS-MOD-00096
EKS-MUP-00098
EKS-MYL-00109
EKS-ORN-00125
EKS-OTG-00102
EKS-RAN-00095
EKS-SAH-00092
EKS-SUS-00086
EKS-TAG-00131
EKS-XIM-00122
Gene Ontology
GO:0001669; C:acrosomal vesicle
GO:0019861; C:flagellum
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007275; P:multicellular organismal development
GO:0007286; P:spermatid development
KEGG
mmu:22114;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013