EKS-MUM-00049
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00049
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/GRK438.22.8E-131191453263
StatusReviewed
Ensembl ProteinENSMUSP00000070445
UniProt AccessionQ3UYH7; F8VPM8;
Protein NameBeta-adrenergic receptor kinase 2
Protein Synonyms/Alias Beta-ARK-2;
Gene NameAdrbk2
Gene Synonyms/Alias Adrbk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000042249ENSMUSP00000070445ENSMUST00000065167
OrganismMus musculus
Functional DescriptionSpecifically phosphorylates the agonist-occupied form ofthe beta-adrenergic and closely related receptors.
Protein Length688
Protein Sequence
(FASTA)
MADLEAVLAD VSYLMAMEKS KTAPAARASK KVVLPEPSIR SVMQRYLAER NEITFDKIFN 60
QKIGFLLFKD FCLNEIGEAV PQVKFYEEIK EYEKLDNEED RLRRSRQMYD AYIMRELLSS 120
THQFSKQAVE HVQSHLSKKQ VTATLFQPYI EEICESLRGD IFQKFMESDK FTRFCQWKNV 180
ELNIHLSMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRVKMK QGETLALNER 240
IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDMH YHLSQHGVFS EKEMRFYASE 300
IILGLEHMHT CFVVYRDLKP ANILLDEYGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE 360
VLQKGTCYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTVN VQLPDAFSPE 420
LRSLLEGLLQ RDVSQRLGCG GGGARELKEH IFFKGIDWQH VYLRKYPPPL IPPRGEVNAA 480
DAFDIGSFDE EDTKGIKLLD CDQDLYKNFP LVISERWQQE VVETIYDAVN ADTDKIEARR 540
KAKNKQLGQE EDYAMGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQSL 600
LTMEQIMSVE ETQIKDRKCI LLRIKGGKQF VLQCESDPEF AQWLKELTCT FNEAQRLLRR 660
APKFLNKPRA AILEFSKPPL CHRNSSGL 688
Nucleotide Sequence
(FASTA)
ATGGCGGACC TGGAGGCCGT GCTGGCCGAC GTCAGCTACC TGATGGCCAT GGAGAAGAGC 60
AAGACGGCGC CGGCCGCGCG CGCCAGCAAG AAGGTCGTCC TGCCGGAGCC CAGTATCCGG 120
AGTGTGATGC AGAGGTATCT GGCAGAGAGA AACGAAATAA CCTTTGACAA GATTTTCAAT 180
CAGAAAATCG GCTTCCTACT ATTTAAAGAC TTCTGCTTGA ATGAAATTGG GGAAGCAGTG 240
CCTCAGGTGA AATTTTATGA AGAGATAAAA GAATATGAGA AGCTGGACAA CGAAGAGGAT 300
AGGCTACGCC GGAGCCGGCA GATGTACGAC GCCTACATCA TGAGGGAGCT CCTATCCAGC 360
ACACACCAAT TCTCAAAGCA AGCTGTAGAA CATGTCCAGA GCCATCTCTC CAAGAAACAG 420
GTGACGGCTA CACTTTTCCA GCCATACATA GAAGAAATCT GTGAAAGCCT TCGTGGGGAT 480
ATTTTCCAAA AGTTTATGGA AAGCGATAAA TTCACTAGAT TCTGTCAGTG GAAGAACGTG 540
GAGTTGAATA TTCACCTGAG CATGAACGAC TTCAGTGTGC ACAGGATCAT CGGCCGAGGA 600
GGGTTTGGGG AAGTTTATGG CTGCAGGAAA GCAGACACCG GTAAAATGTA TGCCATGAAG 660
TGCTTAGACA AGAAAAGGGT GAAGATGAAG CAGGGGGAGA CTCTGGCTTT GAACGAGAGG 720
ATCATGCTGT CTCTCGTTAG CACTGGGGAT TGTCCCTTTA TTGTCTGCAT GACCTACGCC 780
TTCCACACGC CGGACAAACT CTGCTTCATC CTGGACCTGA TGAACGGGGG CGACATGCAC 840
TACCATCTCT CTCAACACGG GGTGTTTTCT GAGAAGGAGA TGCGGTTTTA TGCCAGCGAG 900
ATCATCCTGG GCCTCGAGCA CATGCACACC TGCTTCGTAG TCTACAGAGA CCTGAAGCCT 960
GCGAACATCC TCCTAGATGA ATATGGGCAC GTGAGGATAT CGGATCTCGG CCTTGCCTGC 1020
GATTTCTCCA AAAAGAAGCC TCATGCCAGC GTGGGCACCC ATGGGTACAT GGCTCCCGAG 1080
GTGTTGCAGA AGGGAACGTG CTATGACAGC AGCGCCGACT GGTTCTCCCT GGGCTGTATG 1140
CTCTTCAAGC TTCTGCGGGG CCACAGCCCC TTCAGGCAGC ATAAAACCAA AGACAAGCAT 1200
GAGATAGACC GAATGACCCT GACCGTGAAC GTGCAGCTTC CAGATGCCTT CTCCCCTGAG 1260
CTGAGGTCCC TCTTAGAGGG TTTGCTCCAG CGGGACGTGA GCCAGCGGCT GGGCTGCGGA 1320
GGAGGAGGGG CACGAGAGTT GAAGGAGCAC ATCTTCTTCA AGGGCATTGA CTGGCAGCAT 1380
GTGTACTTAC GGAAGTACCC GCCACCCCTA ATCCCTCCTC GGGGAGAGGT CAACGCTGCA 1440
GATGCCTTCG ATATCGGCTC CTTCGATGAG GAAGACACCA AAGGCATTAA GCTGTTGGAC 1500
TGTGACCAGG ACCTCTATAA GAACTTCCCA CTGGTGATCT CCGAGCGCTG GCAGCAAGAA 1560
GTGGTGGAGA CCATCTATGA CGCCGTCAAT GCTGATACTG ATAAAATCGA GGCCAGGAGG 1620
AAGGCTAAAA ATAAGCAACT TGGTCAAGAG GAAGATTACG CTATGGGGAA GGACTGCATC 1680
ATGCACGGGT ACATGCTGAA GCTGGGGAAC CCCTTTCTCA CACAGTGGCA AAGACGCTAT 1740
TTTTACCTGT TCCCCAACAG ACTGGAGTGG AGAGGAGAGG GCGAGTCTCG GCAAAGTCTA 1800
CTGACCATGG AACAGATCAT GTCTGTGGAG GAGACCCAGA TTAAAGACAG AAAGTGCATC 1860
TTACTCAGGA TAAAGGGAGG GAAGCAATTT GTCTTGCAAT GTGAGAGTGA CCCCGAGTTT 1920
GCACAGTGGC TGAAGGAGCT GACCTGCACC TTCAATGAGG CCCAGAGACT GCTGCGCCGT 1980
GCCCCCAAAT TCCTCAACAA ACCACGGGCC GCCATCCTGG AGTTCTCCAA GCCACCACTG 2040
TGTCACAGAA ATAGCAGCGG CCTCTGA 2067
Domain Profile
S: 1     freyrvlGkGGfGevcacqvkatGkmyalkklekkrikkrkgealalnekkilekv...d  57
         f+++r++G+GGfGev++c++++tGkmya+k+l+kkr+k+++ge+lalne+++l+ v   d
Q: 191   FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVstgD  250
         899*****************************************************9999
S: 58    srfvvslayafetkdklclvltlmnGGdlkyhlynleeggfeeeralfyaaeiilGlehl  117
         ++f+v+++yaf+t+dklc++l+lmnGGd++yhl+  ++g+f+e++++fya+eiilGleh+
Q: 251   CPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLS--QHGVFSEKEMRFYASEIILGLEHM  308
         **********************************..************************
S: 118   hkerivyrdlkpenillddkGhvrisdlGlavelkekekikgrvGtvGymapevlkkek.  176
         h+ ++vyrdlkp+nilld++GhvrisdlGla+++++k k++++vGt+Gymapevl+k++ 
Q: 309   HTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQKGTc  367
         ***********************************99.9*******************99
S: 177   ydfsadwfalGcllyelikgkspfrqrkekvkkeevdrrvleeevkysekfseeakslle  236
         yd+sadwf+lGc+l++l++g+spfrq+k+k +k+e+dr++l+ +v++++ fs+e++slle
Q: 368   YDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTVNVQLPDAFSPELRSLLE  426
         ******************************.*****************************
S: 237   allekdvekrlGcreegaeevkehplf  263
         +ll++dv++rlGc ++ga+e+keh +f
Q: 427   GLLQRDVSQRLGCGGGGARELKEHIFF  453
         *************************99
Domain Sequence
(FASTA)
FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRVKMK QGETLALNER IMLSLVSTGD 60
CPFIVCMTYA FHTPDKLCFI LDLMNGGDMH YHLSQHGVFS EKEMRFYASE IILGLEHMHT 120
CFVVYRDLKP ANILLDEYGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE VLQKGTCYDS 180
SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTVN VQLPDAFSPE LRSLLEGLLQ 240
RDVSQRLGCG GGGARELKEH IFF 263
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00042
EKS-BOT-00047
EKS-CAE-00036
EKS-CAJ-00047
EKS-CAF-00047
EKS-CAP-00047
EKS-CII-00018
EKS-CIS-00055
EKS-DAR-00058
EKS-DRM-00018
EKS-EQC-00044
EKS-GAG-00038
EKS-GOG-00044
EKS-HOS-00047
EKS-LAC-00049
EKS-LOA-00045
EKS-MAM-00044
EKS-MEG-00038
EKS-MOD-00046
EKS-MUP-00048
EKS-MYL-00052
EKS-NOL-00046
EKS-ORN-00063
EKS-ORC-00044
EKS-ORL-00063
EKS-OTG-00049
EKS-PAT-00043
EKS-PES-00041
EKS-POA-00042
EKS-SAH-00045
EKS-SUS-00038
EKS-TAG-00042
EKS-TAR-00063
EKS-TEN-00065
EKS-TUT-00049
EKS-XET-00047
EKS-XIM-00061
Gene Ontology
GO:0005524; F:ATP binding
GO:0047696; F:beta-adrenergic receptor kinase activity
GO:0004703; F:G-protein coupled receptor kinase activity
GO:0005543; F:phospholipid binding
GO:0031623; P:receptor internalization
GO:0007165; P:signal transduction
GO:0038032; P:termination of G-protein coupled receptor signaling pathway
KEGG
mmu:320129;
InterPros
IPR000961; AGC-kinase_C.
IPR000239; GPCR_kinase.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR000342; Regulat_G_prot_signal.
IPR016137; Regulat_G_prot_signal_superfam.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00615; RGS; 1.
SMARTs
SM00233; PH; 1.
SM00315; RGS; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50132; RGS; 1.
Prints
PR00717; GPCRKINASE.
Created Date20-Feb-2013