EPS-MUM-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PTP-Other/TULA-1	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSMUSP00000045890

UniProt Accession

Q3V3E1; Q3TED7;

Protein Name

Ubiquitin-associated and SH3 domain-containing protein A

Protein Synonyms/Alias

Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1;

Gene Name

Ubash3a

Gene Synonyms/Alias

Ubash3a; Sts2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000042345	ENSMUSP00000119279	ENSMUST00000144772
ENSMUSG00000042345	ENSMUSP00000134557	ENSMUST00000173776
ENSMUSG00000042345	ENSMUSP00000045890	ENSMUST00000048656

Organism

Mus musculus

Functional Description

Interferes with CBL-mediated down-regulation anddegradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.

Protein Length

624

Protein Sequence
(FASTA)

MAAGETQLYA KVSNKLKGRS TPSLLDPLLA MGFPTHTALK ALAATGRKTA EAAADWLHGH 60

CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESRRQCA KNRAHEVFPH VTLCDFFTCE 120

DQKVECLYEA LRRAGDRILG SFPTLVPLVL HSSISYLGFF INDSPADAIR EFAMAFATEA 180

AVLADCTIKP CTKQLHLTLA HKFYPHHQRT LEQLAKAIQP SHSCQWTAAL YSRDMRFVHY 240

QTLKALFQYK PQNADELMLS AGDYIFVDPT QQEEASEGWA IGISHRTGCR GFLPENYTER 300

ANEADTWVKH RTYTFNLAMD LNSRKDFEAS CRGNGEPHTP SMSKSVSSIQ ALQATISRRG 360

ILVVRHGERV DQVFGKSWLQ QCTTADGKYY RPDLNFPRSL PRRSNGIKDF ENDPPLSSCG 420

IFQARLAGEA LLDSGVRVTA VFASPALRCV QTAKHILEEL KLEKKLKIRV EPGIFEWMKW 480

EASKATLTFL TLEELKEANF NVDLDYRPAL PRCSLMPAES YDQYVERCAV SMGQIINTCP 540

QDMGITLIVS HSSALDSCTR PLLGLPPREC GDFAQLVRKI PSLGMCFCEE NREDGKWDLV 600

NPPVKTLTHG ANSVFNWRNW ISSN 624

Nucleotide Sequence
(FASTA)

ATGGCTGCGG GGGAGACACA GCTCTATGCC AAGGTCTCCA ACAAGCTCAA GGGCCGCAGC 60

ACCCCCTCAC TCCTGGATCC CCTCCTGGCC ATGGGCTTCC CCACACATAC CGCGCTCAAA 120

GCACTAGCGG CCACAGGGAG GAAGACAGCC GAGGCGGCAG CAGACTGGCT GCATGGTCAC 180

TGCAATGACC CTTCTCTGGA TGACCCTATC CCTCAGGAGT ATGCTCTCTT CCTCTGCCCC 240

ACGGGCCCCT TGCTGGAAAA ACTCCAAGAG TTCTGGAGAG AGAGCAGACG GCAGTGTGCA 300

AAGAACAGAG CACATGAGGT CTTCCCTCAC GTGACACTCT GTGACTTTTT CACGTGTGAA 360

GACCAGAAGG TGGAGTGCTT GTATGAGGCT CTGAGACGTG CAGGGGACAG GATCCTGGGC 420

TCCTTCCCCA CCCTGGTTCC TCTTGTTCTC CATTCTTCCA TCAGCTACCT CGGCTTCTTC 480

ATCAACGACA GCCCCGCTGA CGCCATCCGG GAATTCGCCA TGGCGTTTGC CACAGAGGCG 540

GCAGTCCTGG CAGACTGTAC CATCAAGCCC TGCACCAAGC AGCTGCACCT GACCTTGGCC 600

CATAAGTTCT ACCCTCACCA TCAAAGGACC CTGGAGCAGC TGGCCAAAGC CATCCAGCCC 660

AGCCACTCCT GCCAATGGAC AGCTGCCCTG TACTCCCGAG ACATGCGTTT TGTGCACTAC 720

CAGACCCTGA AGGCGCTGTT CCAGTACAAA CCCCAGAATG CAGATGAGCT AATGCTCAGT 780

GCTGGTGACT ACATCTTCGT GGACCCCACT CAGCAAGAAG AGGCCAGCGA GGGCTGGGCC 840

ATTGGGATCT CACATCGGAC TGGCTGCCGG GGCTTCTTGC CAGAGAACTA CACGGAGCGA 900

GCCAATGAGG CTGACACCTG GGTTAAGCAC AGGACGTATA CATTCAATCT AGCCATGGAC 960

CTGAACTCTA GGAAGGATTT TGAAGCCAGT TGCAGGGGAA ATGGGGAACC CCACACTCCG 1020

TCAATGTCAA AGAGTGTTAG CAGCATACAA GCTTTGCAGG CTACCATCTC GAGGAGAGGC 1080

ATTCTGGTCG TACGTCATGG CGAGAGAGTG GACCAGGTCT TTGGGAAGTC TTGGCTACAG 1140

CAGTGTACTA CTGCTGATGG AAAATACTAC AGGCCAGACC TGAACTTCCC CCGCAGCCTG 1200

CCAAGGAGGA GCAACGGCAT CAAAGACTTT GAAAACGATC CACCGCTATC ATCCTGTGGA 1260

ATTTTCCAGG CCAGACTTGC CGGAGAAGCC CTGCTGGACA GCGGCGTCAG AGTCACCGCG 1320

GTCTTCGCGT CTCCAGCCCT GCGCTGCGTG CAGACAGCCA AGCACATCCT AGAAGAACTC 1380

AAACTGGAGA AGAAGCTGAA GATAAGAGTT GAGCCTGGAA TCTTCGAGTG GATGAAGTGG 1440

GAAGCCAGCA AGGCCACACT GACCTTCTTG ACCTTGGAGG AGCTGAAAGA AGCAAACTTC 1500

AATGTTGACC TTGATTATAG GCCAGCATTG CCCCGCTGCT CCCTCATGCC AGCTGAGAGC 1560

TATGACCAGT ACGTGGAGAG ATGTGCCGTG AGCATGGGGC AGATCATCAA CACATGCCCA 1620

CAGGACATGG GCATTACACT CATCGTGAGC CACAGCTCAG CGCTCGACTC CTGCACAAGG 1680

CCACTCCTCG GGCTCCCACC CAGAGAATGT GGGGATTTCG CCCAACTGGT AAGAAAGATT 1740

CCATCTCTGG GCATGTGCTT CTGTGAGGAA AACAGAGAGG ACGGAAAGTG GGACCTGGTG 1800

AATCCGCCAG TAAAGACGCT GACACATGGG GCCAACTCGG TCTTTAACTG GAGAAACTGG 1860

ATCTCAAGCA ACTGA 1875

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

3D-structure; Complete proteome; Cytoplasm; Nucleus; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0050860	; P:negative regulation of T cell receptor signaling pathway
GO:0001817	; P:regulation of cytokine production

KEGG

mmu:328795

;

InterPros

IPR013078	; His_Pase_superF_clade-1.
IPR001452	; SH3_domain.
IPR009060	; UBA-like.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00300

; His_Phos_1; 1.

SMARTs

SM00326

; SH3; 1.

Prosites

PS50002	; SH3; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013