EKS-MUM-00502

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00502

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	345.7	4.7E-103	20	316	297

Status

Reviewed

Ensembl Protein

ENSMUSP00000040315

UniProt Accession

Q61532; Q497T9; Q6YKB0; Q7TT30; Q80XH5; Q922U4; Q9JLU6;

Protein Name

Mitogen-activated protein kinase 6

Protein Synonyms/Alias

MAP kinase 6; MAPK 6; Extracellular signal-regulated kinase 3; ERK-3;

Gene Name

Mapk6

Gene Synonyms/Alias

Mapk6; Erk3, Prkm4, Prkm6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000042688	ENSMUSP00000040315	ENSMUST00000049355
ENSMUSG00000042688	ENSMUSP00000129024	ENSMUST00000168937

Organism

Mus musculus

Functional Description

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.

Protein Length

720

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILDSIPV VHEEDRQELL SVIPVYIRND MTEPHRPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTSYS 420

AEPCWQYPDH HENKYCDLEC SHTCNYKTRS SPYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKR GKSKCERNGL VKAQIALEEA SQQLAERERG QGFDFDSFIA GTIQLSAQHQ 540

SADVVDKLND LNSSVSQLEL KSLISKSVSR EKQEKGRANL AQLGALYQSS WDSQFVSGGE 600

ECFLISQFCC EVRKDEHAEK ENTYTSYLDK FFSRKEDSEM LETEPVEEGK RGERGREAGL 660

LSGGGEFLLS KQLESIGTPQ FHSPVGSPLK SIQATLTPSA MKSSPQIPHK TYSSILKHLN 720

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTCGAAAG TCTCATGAAC ATTCATGGCT TTGATCTGGG CTCTAGGTAC 60

ATGGACTTAA AACCATTGGG CTGCGGAGGC AATGGCTTGG TCTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTCA CCGATCCCCA GAGTGTCAAA 180

CATGCTCTCC GTGAAATCAA AATTATTCGA AGACTTGACC ACGATAACAT TGTGAAAGTG 240

TTTGAAATTC TTGGTCCCAG TGGAAGCCAG TTAACAGACG ATGTGGGCTC TCTCACGGAG 300

CTGAATAGCG TCTACATTGT TCAGGAGTAT ATGGAGACAG ACTTGGCGAA TGTGCTGGAG 360

CAGGGCCCTT TACTGGAAGA GCATGCCAGG CTTTTCATGT ATCAGCTGCT ACGTGGGCTC 420

AAATATATCC ATTCTGCAAA CGTACTGCAC AGAGATCTCA AGCCAGCTAA TCTTTTCATT 480

AACACTGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGCC TGGCACGGAT CATGGATCCT 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CCAAATGGTA CAGATCTCCA 600

CGGCTTTTAC TTTCTCCTAA TAATTACACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AGATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TCCTCGACTC CATCCCTGTT GTGCACGAGG AGGATCGGCA GGAGCTTCTC 780

AGCGTGATTC CAGTTTACAT TAGAAACGAC ATGACTGAGC CACACAGACC GCTCACTCAG 840

CTGCTGCCGG GGATCAGCCG AGAAGCACTG GATTTCCTGG AGCAGATTCT GACTTTCAGC 900

CCCATGGACC GGCTGACAGC TGAGGAAGCC CTTTCCCATC CTTACATGAG CATCTACTCC 960

TTCCCGACGG ATGAGCCCAT CTCAAGCCAC CCTTTCCACA TAGAGGACGA AGTGGACGAC 1020

ATTTTGCTTA TGGATGAAAC ACACAGTCAC ATTTATAACT GGGAAAGGTA CCACGATTGT 1080

CAGTTCTCGG AGCATGACTG GCCTATTCAT AACAACTTTG ATATCGATGA GGTGCAGCTT 1140

GACCCAAGAG CTCTGTCTGA CGTCACCGAT GAAGAAGAAG TCCAAGTTGA TCCTCGAAAA 1200

TACTTGGATG GAGACCGAGA GAAGTATCTA GAGGATCCCG CCTTCGACAC CAGCTACTCT 1260

GCTGAACCCT GCTGGCAGTA CCCAGATCAC CACGAGAACA AGTACTGCGA TCTGGAGTGT 1320

AGCCACACCT GTAACTACAA AACAAGATCA TCACCATACT TAGATAACCT GGTGTGGAGG 1380

GAGAGCGAGG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTTTC CAACTGGAAA 1440

GAGCAAAGTA AAGAAAAATC CGATAAGAGA GGCAAGTCCA AGTGTGAGAG GAACGGGTTG 1500

GTCAAGGCGC AGATCGCGCT AGAGGAAGCA TCCCAGCAGC TGGCTGAGAG GGAGAGGGGC 1560

CAAGGCTTCG ACTTTGACTC CTTCATCGCG GGGACCATTC AGCTCAGTGC CCAGCATCAG 1620

TCTGCTGACG TAGTTGACAA GTTAAACGAC TTGAATAGCT CAGTGTCCCA GCTAGAATTG 1680

AAAAGCCTGA TATCCAAGTC AGTCAGCCGA GAAAAGCAAG AAAAGGGAAG GGCTAACCTG 1740

GCCCAGCTGG GAGCCTTGTA CCAGTCCTCC TGGGACAGCC AGTTTGTGAG TGGCGGGGAG 1800

GAGTGCTTCC TCATCAGTCA GTTTTGTTGT GAGGTCAGGA AGGACGAGCA TGCGGAGAAG 1860

GAGAACACCT ACACCAGCTA TTTGGACAAG TTTTTTAGCA GGAAGGAGGA TTCCGAAATG 1920

CTAGAAACTG AGCCAGTGGA GGAAGGGAAG CGTGGGGAGA GAGGCCGTGA GGCAGGGCTT 1980

CTGAGCGGCG GTGGGGAGTT CCTCCTGAGC AAGCAGCTGG AGTCCATAGG CACCCCGCAG 2040

TTCCACAGCC CAGTGGGGTC CCCACTCAAG TCCATCCAGG CCACCTTGAC ACCTTCCGCT 2100

ATGAAATCTT CCCCTCAAAT CCCTCACAAG ACATACAGCA GCATTCTGAA ACATCTGAAC 2160

TAA 2163

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++il+ ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ ++++++++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILDSIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHRPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0007049	; P:cell cycle

KEGG

mmu:50772

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013