EKS-MUM-00436
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00436
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR580.24.1E-174611946336
StatusUnreviewed
Ensembl ProteinENSMUSP00000135582
UniProt AccessionQ3UEW6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFlt3
Gene Synonyms/Alias Flt3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000042817ENSMUSP00000106178ENSMUST00000110549
ENSMUSG00000042817ENSMUSP00000039041ENSMUST00000049324
ENSMUSG00000042817ENSMUSP00000135582ENSMUST00000176456
OrganismMus musculus
Functional Description
Protein Length962
Protein Sequence
(FASTA)
MRALAQRSDR RLLLLVVLSV MILETVTNQD LPVIKCVLIS HENNGSSAGK PSSYRMVRGS 60
PEDLQCAPRR QSEGTVYEAA TVEVAESGSI TLQVQLATPG DLSCLWVFKH SSLGCQPHFD 120
LQNRGIVSMA ILNVTETQAG EYLLHIQSEA ANYTVLFTVN VRDTQLYVLR RPYFRKMENQ 180
DALLCISEGV PEPTVEWVLC SSHRESCKEE GPAVVRKEEK VLHELFGTDI RCCARNALGR 240
ECTKLFTIDL NQAPQSTLPQ LFLKVGEPLW IRCKAIHVNH GFGLTWELED KALEEGSYFE 300
MSTYSTNRTM IRILLAFVSS VGRNDTGYYT CSSSKHPSQS ALVTILEKGF INATSSQEEY 360
EIDPYEKFCF SVRFKAYPRI RCTWIFSQAS FPCEQRGLED GYSISKFCDH KNKPGEYIFY 420
AENDDAQFTK MFTLNIRKKP QVLANASASQ ASCSSDGYPL PSWTWKKCSD KSPNCTEEIP 480
EGVWNKKANR KVFGQWVSSS TLNMSEAGKG LLVKCCAYNS MGTSCETIFL NSPGPFPFIQ 540
DNISFYATIG LCLPFIVVLI VLICHKYKKQ FRYESQLQMI QVTGPLDNEY FYVDFRDYEY 600
DLKWEFPREN LEFGKVLGSG AFGRVMNATA YGISKTGVSI QVAVKMLKEK ADSCEKEALM 660
SELKMMTHLG HHDNIVNLLG ACTLSGPVYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK 720
EHNFSFYPTF QAHSNSSMPG SREVQLHPPL DQLSGFNGNL IHSEDEIEYE NQKRLAEEEE 780
EDLNVLTFED LLCFAYQVAK GMEFLEFKSC VHRDLAARNV LVTHGKVVKI CDFGLARDIL 840
SDSSYVVRGN ARLPVKWMAP ESLFEGIYTI KSDVWSYGIL LWEIFSLGVN PYPGIPVDAN 900
FYKLIQSGFK MEQPFYATEG IYFVMQSCWA FDSRKRPSFP NLTSFLGCQL AEAEEAVCGG 960
LA 962
Nucleotide Sequence
(FASTA)
ATGCGGGCGT TGGCGCAGCG CAGCGACCGG CGGCTGCTGC TGCTTGTTGT TTTGTCAGTA 60
ATGATTCTTG AGACCGTTAC AAACCAAGAC CTGCCTGTGA TCAAGTGTGT TTTAATCAGT 120
CATGAGAACA ATGGCTCATC AGCGGGAAAG CCATCATCGT ACCGAATGGT GCGAGGATCC 180
CCAGAAGACC TCCAGTGTGC CCCGAGGCGC CAGAGTGAAG GGACGGTATA TGAAGCGGCC 240
ACCGTGGAGG TGGCCGAGTC TGGGTCCATC ACCCTGCAAG TGCAGCTCGC CACCCCAGGG 300
GACCTTTCCT GCCTCTGGGT CTTTAAGCAC AGCTCCCTGG GCTGCCAGCC GCACTTTGAT 360
TTACAAAACA GAGGAATCGT TTCCATGGCC ATCTTGAACG TGACAGAGAC CCAGGCAGGA 420
GAATACCTAC TCCATATTCA GAGCGAAGCC GCCAACTACA CAGTACTGTT CACAGTGAAT 480
GTAAGAGATA CACAGCTGTA CGTGCTAAGA AGACCTTACT TTAGGAAGAT GGAAAACCAG 540
GACGCACTGC TCTGCATCTC CGAGGGTGTT CCAGAGCCCA CTGTGGAGTG GGTGCTCTGC 600
AGCTCCCACA GGGAAAGCTG TAAAGAAGAA GGCCCTGCTG TTGTCAGAAA GGAGGAAAAG 660
GTACTTCATG AGTTGTTCGG AACAGACATC AGATGCTGTG CTAGAAATGC ACTGGGCCGC 720
GAATGCACCA AGCTGTTCAC CATAGATCTA AACCAGGCTC CTCAGAGCAC ACTGCCCCAG 780
TTATTCCTGA AAGTGGGGGA ACCCTTGTGG ATCAGGTGTA AGGCCATCCA TGTGAACCAT 840
GGATTCGGGC TCACCTGGGA GCTGGAAGAC AAAGCCCTGG AGGAGGGCAG CTACTTTGAG 900
ATGAGTACCT ACTCCACAAA CAGGACCATG ATTCGGATTC TCTTGGCCTT TGTGTCTTCC 960
GTGGGAAGGA ACGACACCGG ATATTACACC TGCTCTTCCT CAAAGCACCC CAGCCAGTCA 1020
GCGTTGGTGA CCATCCTAGA AAAAGGGTTT ATAAACGCTA CCAGCTCGCA AGAAGAGTAT 1080
GAAATTGACC CGTACGAAAA GTTCTGCTTC TCAGTCAGGT TTAAAGCGTA CCCACGAATC 1140
CGATGCACGT GGATCTTCTC TCAAGCCTCA TTTCCTTGTG AACAGAGAGG CCTGGAGGAT 1200
GGGTACAGCA TATCTAAATT TTGCGATCAT AAGAACAAGC CAGGAGAGTA CATATTCTAT 1260
GCAGAAAATG ATGACGCCCA GTTCACCAAA ATGTTCACGC TGAATATAAG AAAGAAACCT 1320
CAAGTGCTAG CAAATGCCTC AGCCAGCCAG GCGTCCTGTT CCTCTGATGG CTACCCGCTA 1380
CCCTCTTGGA CCTGGAAGAA GTGTTCGGAC AAATCTCCCA ATTGCACGGA GGAAATCCCA 1440
GAAGGAGTTT GGAATAAAAA GGCTAACAGA AAAGTGTTTG GCCAGTGGGT GTCGAGCAGT 1500
ACTCTAAATA TGAGTGAGGC CGGGAAAGGG CTTCTGGTCA AATGCTGTGC GTACAATTCT 1560
ATGGGCACGT CTTGCGAAAC CATCTTTTTA AACTCACCAG GCCCCTTCCC TTTCATCCAA 1620
GACAACATCT CCTTCTATGC GACCATTGGG CTCTGTCTCC CCTTCATTGT TGTTCTCATT 1680
GTGTTGATCT GCCACAAATA CAAAAAGCAA TTTAGGTACG AGAGTCAGCT GCAGATGATC 1740
CAGGTGACTG GCCCCCTGGA TAACGAGTAC TTCTACGTTG ACTTCAGGGA CTATGAATAT 1800
GACCTTAAGT GGGAGTTCCC GAGAGAGAAC TTAGAGTTTG GGAAGGTCCT GGGGTCTGGC 1860
GCTTTCGGGA GGGTGATGAA CGCCACGGCC TATGGCATTA GTAAAACGGG AGTCTCAATT 1920
CAGGTGGCGG TGAAGATGCT AAAAGAGAAA GCTGACAGCT GTGAAAAAGA AGCTCTCATG 1980
TCGGAGCTCA AAATGATGAC CCACCTGGGA CACCATGACA ACATCGTGAA TCTGCTGGGG 2040
GCATGCACAC TGTCAGGGCC AGTGTACTTG ATTTTTGAAT ATTGTTGCTA TGGTGACCTC 2100
CTCAACTACC TAAGAAGTAA AAGAGAGAAG TTTCACAGGA CATGGACAGA GATTTTTAAG 2160
GAACATAATT TCAGTTTTTA CCCTACTTTC CAGGCACATT CAAATTCCAG CATGCCTGGT 2220
TCACGAGAAG TTCAGTTACA CCCGCCCTTG GATCAGCTCT CAGGGTTCAA TGGGAATTTA 2280
ATTCATTCTG AAGATGAGAT TGAATATGAA AACCAGAAGA GGCTGGCAGA AGAAGAGGAG 2340
GAAGATTTGA ACGTGCTGAC GTTTGAAGAC CTCCTTTGCT TTGCGTACCA AGTGGCCAAA 2400
GGCATGGAAT TCCTGGAGTT CAAGTCGTGT GTCCACAGAG ACCTGGCAGC CAGGAATGTG 2460
TTGGTCACCC ACGGGAAGGT GGTGAAGATC TGTGACTTTG GACTGGCCCG AGACATCCTG 2520
AGCGACTCCA GCTACGTCGT CAGGGGCAAC GCACGGCTGC CGGTGAAGTG GATGGCACCT 2580
GAGAGCTTAT TTGAAGGGAT CTACACAATC AAGAGTGACG TCTGGTCCTA CGGCATCCTT 2640
CTCTGGGAGA TATTTTCACT GGGTGTGAAC CCTTACCCTG GCATTCCTGT CGACGCTAAC 2700
TTCTATAAAC TGATTCAGAG TGGATTTAAA ATGGAGCAGC CATTCTATGC CACAGAAGGG 2760
ATATACTTTG TAATGCAATC CTGCTGGGCT TTTGACTCAA GGAAGCGGCC ATCCTTCCCC 2820
AACCTGACTT CATTTTTAGG ATGTCAGCTG GCAGAGGCAG AAGAAGCGGT ATGTGGAGGC 2880
TTGGCTTAA 2889
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafG+v++atayG+sk++++++vavkmlk++a+s+ekealmselk+++hlG
Q: 611   LEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLG  670
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact +Gp+y+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 671   HHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  729
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++++s++s+++s+e v+l++ ++++s ++ + ++se++ +++++++ a++eeed
Q: 730   ------FQAHSNSSMPGSRE-VQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEED  782
         ......99************.***************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardi++d
Q: 783   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSD  842
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         s+yvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 843   SSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  902
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yate iy +mq+cw+++++krpsf +l+++l
Q: 903   KLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFL  946
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGRVMNATA YGISKTGVSI QVAVKMLKEK ADSCEKEALM SELKMMTHLG 60
HHDNIVNLLG ACTLSGPVYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QAHSNSSMPG SREVQLHPPL DQLSGFNGNL IHSEDEIEYE NQKRLAEEEE EDLNVLTFED 180
LLCFAYQVAK GMEFLEFKSC VHRDLAARNV LVTHGKVVKI CDFGLARDIL SDSSYVVRGN 240
ARLPVKWMAP ESLFEGIYTI KSDVWSYGIL LWEIFSLGVN PYPGIPVDAN FYKLIQSGFK 300
MEQPFYATEG IYFVMQSCWA FDSRKRPSFP NLTSFL 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TAR-00506
EKS-TEN-00504
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0043548; F:phosphatidylinositol 3-kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
mmu:14255;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013