| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00099 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/TSSK | 410.3 | 9.3E-123 | 12 | 272 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000051035 |
| UniProt Accession | O54863; Q6P8M9; |
| Protein Name | Testis-specific serine/threonine-protein kinase 2 |
| Protein Synonyms/Alias | TSK-2; TSK2; TSSK-2; Testis-specific kinase 2; Serine/threonine-protein kinase 22B; |
| Gene Name | Tssk2 |
| Gene Synonyms/Alias | Tssk2; Stk22b; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Testis-specific serine/threonine-protein kinase requiredduring spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. |
| Protein Length | 358 |
Protein Sequence
(FASTA) | | MDDAAVLRKK GYIVGINLGK GSYAKVKSAY SERLKFNVAV KIIDRKKTPT DFVERFLPRE 60 | | MDILATVNHR SIIKTYEIFE TSDGRIYIVM ELGVQGDLLE FIKCRGALHE DVARKMFRQL 120 | | SSAVKYCHDL DVVHRDLKCE NLLLDKDFNI KLSDFGFSKR CLRDGSGRIV LSKTFCGSAA 180 | | YAAPEVLQGI PYQPKVYDIW SLGVILYIMV CGSMPYDDSD IKKMLRIQKE HRVDFPRSKN 240 | | LTGECKDLIY RILQPDVNRR LHIDEILSHS WLQPPKPKAM SSASFKREGE GKYRADCKLD 300 | | TRPGSRPEHR PDHKLATKPQ QRMLVTPENE DRMEDRLAET SRAKDHHISG AEVEKAST 358 |
|
Nucleotide Sequence
(FASTA) | | ATGGACGATG CGGCGGTCCT AAGGAAGAAG GGTTACATCG TGGGAATCAA TCTGGGCAAG 60 | | GGCTCCTACG CAAAAGTCAA ATCTGCCTAC TCAGAGCGCC TCAAGTTCAA TGTGGCAGTC 120 | | AAGATCATAG ACCGCAAGAA AACACCCACT GACTTTGTGG AGAGATTCCT TCCTAGGGAG 180 | | ATGGACATCC TGGCGACCGT CAACCACCGT TCCATCATTA AGACCTACGA GATCTTTGAG 240 | | ACCTCTGATG GACGCATCTA CATTGTCATG GAGCTGGGCG TCCAGGGCGA CCTCCTCGAG 300 | | TTCATCAAGT GCCGAGGAGC CCTGCATGAG GATGTGGCAC GCAAGATGTT CCGCCAGCTC 360 | | TCCTCAGCCG TCAAGTACTG CCACGACCTG GATGTCGTCC ACCGAGACCT CAAATGTGAG 420 | | AACCTTCTGC TTGACAAGGA CTTCAACATC AAACTGTCTG ACTTCGGCTT CTCCAAGCGC 480 | | TGCCTGCGGG ACGGGAGTGG GCGCATCGTC CTCAGCAAAA CCTTCTGTGG GTCAGCAGCT 540 | | TATGCAGCCC CCGAGGTGCT GCAGGGCATC CCCTACCAGC CCAAGGTGTA TGACATCTGG 600 | | AGCCTGGGTG TGATTCTCTA CATCATGGTC TGTGGCTCCA TGCCCTACGA TGACTCTGAC 660 | | ATCAAAAAGA TGCTGCGCAT CCAGAAGGAG CACCGAGTGG ACTTCCCACG CTCCAAGAAC 720 | | CTAACTGGTG AGTGCAAGGA CCTCATCTAC CGCATCCTAC AGCCAGATGT CAACCGGCGG 780 | | CTGCACATTG ATGAGATCCT TAGCCACTCA TGGCTACAGC CCCCCAAGCC CAAAGCCATG 840 | | TCTTCTGCCT CCTTCAAGAG GGAGGGGGAA GGCAAGTATC GAGCTGATTG CAAGTTGGAT 900 | | ACTCGACCAG GCTCCAGACC CGAACACCGG CCTGACCACA AGCTGGCGAC CAAACCCCAG 960 | | CAACGGATGC TGGTGACACC CGAGAATGAA GACAGGATGG AAGACAGGCT GGCTGAGACT 1020 | | TCCAGAGCTA AAGACCATCA CATTTCTGGA GCTGAGGTGG AGAAAGCAAG TACCTAG 1077 |
|
| Domain Profile | S: 1 lklgkkiGeGsyskvkeaysekkklkvavkiidkkkapedyvkkFlPReleilktlkhkn 60 | + +g ++G+Gsy+kvk+ayse+ k++vavkiid+kk+p+d+v++FlPRe++il+t++h++ | Q: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHRS 71 | 67999******************************************************* |
| S: 61 ivklyeiietsd.kiylvlelaaqgdllelikesgaleeeearklfsqlvsavkylhsld 119 | i+k+yei+etsd +iy+v+el+ qgdlle+ik++gal+e+ ark+f+ql+savky+h+ld | Q: 72 IIKTYEIFETSDgRIYIVMELGVQGDLLEFIKCRGALHEDVARKMFRQLSSAVKYCHDLD 131 | ************************************************************ |
| S: 120 ivhRDlkcenilldkkenvklsDFgFakkvkr...skselsktfCGsaaYaaPevlrgik 176 | +vhRDlkcen+lldk++n+klsDFgF+k++ r ++ lsktfCGsaaYaaPevl+gi+ | Q: 132 VVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRdgsGRIVLSKTFCGSAAYAAPEVLQGIP 191 | *******************************9999999********************** |
| S: 177 ydpklsDvWslGvilyvmvvgklPfddsdikkllrsqkkrkvkfpksltlseeckdlile 236 | y+pk++D+WslGvily+mv+g++P+ddsdikk+lr+qk+++v fp+s++l+ eckdli++ | Q: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIKKMLRIQKEHRVDFPRSKNLTGECKDLIYR 251 | ************************************************************ |
| S: 237 llqldakkRltikevlessWl 257 | +lq+d+++Rl+i+e+l++sWl | Q: 252 ILQPDVNRRLHIDEILSHSWL 272 | ********************7 |
|
Domain Sequence
(FASTA) | | YIVGINLGKG SYAKVKSAYS ERLKFNVAVK IIDRKKTPTD FVERFLPREM DILATVNHRS 60 | | IIKTYEIFET SDGRIYIVME LGVQGDLLEF IKCRGALHED VARKMFRQLS SAVKYCHDLD 120 | | VVHRDLKCEN LLLDKDFNIK LSDFGFSKRC LRDGSGRIVL SKTFCGSAAY AAPEVLQGIP 180 | | YQPKVYDIWS LGVILYIMVC GSMPYDDSDI KKMLRIQKEH RVDFPRSKNL TGECKDLIYR 240 | | ILQPDVNRRL HIDEILSHSW L 261 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Developmental protein; Differentiation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |