EKS-MUM-00497

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00497

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.7	1.1E-124	64	359	296

Status

Unreviewed

Ensembl Protein

ENSMUSP00000108467

UniProt Accession

E9QN59;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase 10;

Gene Name

Mapk10

Gene Synonyms/Alias

Mapk10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000046709	ENSMUSP00000055793	ENSMUST00000060871
ENSMUSG00000046709	ENSMUSP00000127193	ENSMUST00000170792
ENSMUSG00000046709	ENSMUSP00000084065	ENSMUST00000086854
ENSMUSG00000046709	ENSMUSP00000108468	ENSMUST00000112847
ENSMUSG00000046709	ENSMUSP00000108469	ENSMUST00000112848
ENSMUSG00000046709	ENSMUSP00000108467	ENSMUST00000112846

Organism

Mus musculus

Functional Description

Protein Length

418

Protein Sequence
(FASTA)

MSLHFLYYCS EPTLDVKIAF CQGFDKHVDV SSIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 360

VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSA 418

Nucleotide Sequence
(FASTA)

ATGAGCCTCC ATTTCTTATA CTACTGCAGT GAACCAACCT TGGATGTGAA AATTGCCTTT 60

TGTCAGGGAT TCGATAAACA CGTGGATGTG TCATCTATTG CCAAACATTA CAACATGAGC 120

AAAAGCAAGG TGGACAACCA GTTCTACAGT GTGGAAGTGG GGGACTCAAC CTTCACCGTT 180

CTTAAGCGCT ACCAGAACCT GAAGCCAATT GGCTCTGGGG CTCAGGGAAT AGTCTGTGCT 240

GCGTACGACG CTGTCCTTGA CAGAAATGTG GCCATTAAGA AGCTCAGCAG ACCCTTCCAG 300

AACCAAACTC ACGCCAAGAG GGCTTACCGG GAGCTGGTCC TCATGAAGTG TGTGAACCAT 360

AAAAACATTA TTAGCTTATT AAATGTTTTT ACACCCCAGA AAACACTGGA GGAGTTCCAA 420

GATGTCTACT TAGTGATGGA ACTGATGGAC GCCAACCTGT GTCAGGTGAT TCAGATGGAG 480

CTGGACCACG AGCGGATGTC TTACTTGCTG TACCAGATGC TGTGTGGCAT CAAGCACCTC 540

CACTCCGCTG GGATCATCCA CAGGGACTTA AAACCCAGTA ACATTGTAGT CAAGTCTGAT 600

TGCACACTGA AAATCCTCGA CTTCGGACTG GCCAGGACAG CGGGTACAAG CTTCATGATG 660

ACTCCGTATG TGGTGACGCG ATATTACAGA GCCCCTGAGG TCATCCTGGG CATGGGCTAC 720

AAGGAGAACG TGGACATATG GTCTGTGGGA TGCATCATGG GAGAAATGGT TCGCCACAAA 780

ATCCTCTTTC CCGGAAGGGA CTATATTGAC CAGTGGAACA AAGTCATCGA GCAGCTAGGA 840

ACTCCGTGTC CAGAGTTCAT GAAGAAATTG CAGCCCACAG TCAGAAACTA CGTGGAGAAT 900

CGGCCCAAGT ACGCAGGACT CACCTTCCCC AAGCTCTTTC CAGATTCCCT CTTCCCAGCG 960

GATTCTGAGC ACAATAAACT TAAAGCCAGC CAAGCCAGGG ATTTGTTGTC TAAGATGTTA 1020

GTGATTGACC CAGCGAAGAG GATATCGGTG GACGACGCAC TGCAGCATCC GTACATCAAC 1080

GTTTGGTACG ACCCGGCTGA AGTGGAGGCG CCTCCGCCTC AGATATATGA TAAGCAGCTG 1140

GATGAAAGGG AGCACACCAT CGAAGAATGG AAAGAACTTA TCTACAAGGA GGTAATGAAC 1200

TCAGAAGAGA AGACTAAGAA TGGCGTAGTC AAAGGCCAGC CCTCGCCTTC AGCTTGA 1257

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 299   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013