EPS-MUM-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	378.6	2.3E-113	229	443	215

Status

Unreviewed

Ensembl Protein

ENSMUSP00000092821

UniProt Accession

Q5DTY5;

Protein Name

Protein Synonyms/Alias

MKIAA1348 protein;

Gene Name

Pdp2

Gene Synonyms/Alias

Pdp2; mKIAA1348;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000048371	ENSMUSP00000092821	ENSMUST00000059588

Organism

Mus musculus

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MSSTVSYWIF NSARNRIALL RGGRRLYSRA ATSRNLLKWR PFSPALASSA LKCGSPPGGF 60

ALRKAYRHTS TEEEDFHLQL SPEQVSDLLR AGESSHKVLD FNNGVPNSVL RFESNQLAAN 120

SPVEDRQGVA TCVQTNGMMF GIFDGHGGHA CAQAVSERLF YYMAVSLMSH QTLEQMEEAT 180

ENMKPLLPIL RWLKHPGDSI YKDVTSVHLD HLRVYWQELL DLHMEMGLSI EEALMYSFQR 240

LDSDISLEIQ APLEDEVTRN LSLQVAFSGA TACMAHVNGV HLHVANAGDC RAILGVQEEN 300

GAWSCLPLTC DHNAWNEAEL SRLKREHPES EDRTLIIDDR LLGVLMPCRA FGDVQLKWSK 360

ELQRNVLARG FDTEALNIYQ FTPPHYYTPP YLTAKPEVTY HRLRRQDKFL VLASDGLWDM 420

LGNEDVVRLV VGHLSKVGRH KPDLDQRPAN LGLMQSLLLQ RKASGLHAAD QNTATHLIRH 480

AIGSNEYGEM EPERLAAMLT LPEDVARMYR DDITVMVVFF NSDSIDTYCK EG 532

Nucleotide Sequence
(FASTA)

ATGTCAAGTA CTGTGTCCTA CTGGATCTTC AATTCTGCAA GGAATCGTAT TGCTCTTTTA 60

CGAGGTGGGA GACGCCTATA CTCAAGGGCT GCCACGAGTA GGAACCTGCT GAAGTGGAGG 120

CCCTTTTCTC CGGCATTGGC ATCATCAGCC CTCAAGTGTG GTTCTCCACC TGGTGGCTTT 180

GCCCTGCGGA AAGCCTACAG ACACACATCA ACCGAGGAAG AGGATTTCCA CCTACAGCTC 240

AGCCCCGAAC AGGTCAGTGA CCTGCTCCGA GCTGGCGAGT CATCCCACAA GGTCCTTGAT 300

TTCAACAACG GAGTACCAAA TTCAGTGTTA AGGTTCGAGA GCAACCAGCT GGCTGCCAAT 360

TCCCCTGTGG AGGACCGGCA AGGTGTGGCT ACCTGCGTCC AAACGAATGG GATGATGTTC 420

GGTATTTTTG ATGGACACGG GGGCCACGCG TGTGCGCAAG CGGTGAGTGA GAGGCTTTTC 480

TACTACATGG CGGTGTCCCT GATGTCCCAT CAGACCTTGG AGCAGATGGA GGAAGCAACG 540

GAAAACATGA AGCCTTTGCT GCCCATCCTG CGTTGGCTCA AGCACCCCGG AGATAGTATT 600

TATAAGGACG TCACGTCCGT GCATCTGGAC CACCTCCGTG TCTATTGGCA GGAGCTCCTT 660

GACCTGCATA TGGAAATGGG GCTGAGCATT GAAGAAGCAT TGATGTACTC CTTCCAGAGA 720

CTGGATTCTG ACATCTCGCT AGAAATCCAG GCTCCTCTGG AAGATGAGGT AACGAGAAAC 780

TTATCCCTCC AGGTTGCTTT CTCTGGGGCA ACAGCCTGCA TGGCCCACGT CAATGGAGTT 840

CACCTGCATG TAGCAAATGC TGGTGACTGC CGGGCTATCC TCGGTGTCCA GGAAGAAAAC 900

GGTGCCTGGT CATGTTTACC TCTTACCTGT GACCACAACG CCTGGAATGA GGCTGAGCTG 960

TCCCGGCTTA AGAGGGAACA CCCCGAGTCC GAGGACAGGA CACTCATCAT AGACGACAGG 1020

CTTCTGGGTG TCCTCATGCC CTGCAGGGCC TTCGGGGATG TCCAGCTAAA GTGGAGCAAA 1080

GAGCTGCAGC GGAATGTCCT CGCAAGGGGC TTTGATACGG AGGCCCTCAA CATCTACCAG 1140

TTTACCCCGC CCCACTACTA CACTCCACCC TACCTGACTG CCAAACCTGA GGTTACCTAC 1200

CACAGGCTAA GGCGCCAGGA TAAGTTCCTG GTGCTGGCCT CAGATGGCCT GTGGGACATG 1260

CTGGGGAATG AGGACGTGGT GAGGCTGGTG GTGGGGCACC TGTCCAAGGT GGGTCGCCAT 1320

AAGCCGGACC TGGACCAAAG ACCAGCCAAC CTAGGCCTCA TGCAGAGCCT GCTGCTGCAG 1380

AGGAAAGCCA GTGGACTCCA TGCGGCTGAC CAGAACACAG CCACGCATCT GATCAGACAC 1440

GCCATCGGGA GCAACGAGTA CGGGGAGATG GAGCCGGAGC GGCTGGCTGC CATGCTGACA 1500

CTGCCAGAGG ATGTGGCCAG GATGTACCGG GATGATATCA CTGTCATGGT GGTGTTTTTT 1560

AACTCTGATT CAATTGATAC CTACTGTAAA GAGGGTTAA 1599

Domain Profile

S: 4     dvkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhvantG  63

          ++eal+++f+rld+disle+q++ edev+r+l+l+va+sGatac+ahv+Gv+lhvan+G

Q: 229   SIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVNGVHLHVANAG  288

         699*********************************************************

S: 64    dsravlGvqeedgswsavklsrdhnaqneselerlkaehpkseaktvikedrllgllipl  123

         d+ra+lGvqee+g ws+++l+ dhna+ne+el+rlk+ehp+se++t+i +drllg+l+p+

Q: 289   DCRAILGVQEENGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLIIDDRLLGVLMPC  348

         ************************************************************

S: 124   rafGdvkfkwskelqkrvvesgfdvladneykfiapnyytppyltaepevtyhrlrpqdk  183

         rafGdv++kwskelq++v+ +gfd++a+n+y+f++p+yytppylta+pevtyhrlr qdk

Q: 349   RAFGDVQLKWSKELQRNVLARGFDTEALNIYQFTPPHYYTPPYLTAKPEVTYHRLRRQDK  408

         ************************************************************

S: 184   flvlasdGlwdllsredvvrlvgeylaeadttlte  218

         flvlasdGlwd+l +edvvrlv+++l++   ++ +

Q: 409   FLVLASDGLWDMLGNEDVVRLVVGHLSKVGRHKPD  443

         **************************998887765

Domain Sequence
(FASTA)

SIEEALMYSF QRLDSDISLE IQAPLEDEVT RNLSLQVAFS GATACMAHVN GVHLHVANAG 60

DCRAILGVQE ENGAWSCLPL TCDHNAWNEA ELSRLKREHP ESEDRTLIID DRLLGVLMPC 120

RAFGDVQLKW SKELQRNVLA RGFDTEALNI YQFTPPHYYT PPYLTAKPEV TYHRLRRQDK 180

FLVLASDGLW DMLGNEDVVR LVVGHLSKVG RHKPD 215

Keyword

Hydrolase; Magnesium; Metal-binding; Protein phosphatase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0004741	; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0004724	; F:magnesium-dependent protein serine/threonine phosphatase activity
GO:0046872	; F:metal ion binding
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013