EKS-MUM-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC478.91.1E-143339597259
StatusUnreviewed
Ensembl ProteinENSMUSP00000062392
UniProt AccessionQ4VA93;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePrkca
Gene Synonyms/Alias Prkca; mCG_140727, RP23-145G23.2-001;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000050965ENSMUSP00000097875ENSMUST00000100302
ENSMUSG00000050965ENSMUSP00000062392ENSMUST00000059595
OrganismMus musculus
Functional Description
Protein Length672
Protein Sequence
(FASTA)
MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA 180
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540
EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660
PQFVHPILQS AV 672
Nucleotide Sequence
(FASTA)
ATGGCTGACG TTTACCCGGC CAACGACTCC ACGGCGTCTC AGGACGTGGC CAACCGCTTC 60
GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCATGAGG TGAAAGACCA CAAATTCATC 120
GCCCGCTTCT TCAAGCAACC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT 180
GGGAAACAAG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TTCATAAGAG GTGCCATGAG 240
TTCGTTACGT TCTCTTGTCC GGGTGCGGAT AAGGGACCTG ACACTGACGA CCCCAGGAGC 300
AAGCACAAGT TCAAAATCCA CACATACGGA AGCCCTACCT TCTGTGATCA CTGTGGGTCC 360
CTGCTCTATG GACTTATCCA CCAAGGGATG AAATGTGACA CCTGCGACAT GAATGTTCAC 420
AAGCAGTGTG TGATCAATGT CCCTAGCCTC TGCGGAATGG ATCACACAGA GAAGAGGGGG 480
CGGATTTATC TGAAGGCTGA GGTCACTGAT GAAAAGCTCC ACGTCACGGT ACGAGATGCA 540
AAAAATCTAA TCCCTATGGA TCCAAATGGG CTTTCGGATC CTTATGTGAA GCTGAAACTT 600
ATCCCTGACC CCAAGAATGA GAGCAAACAG AAAACCAAAA CCATCCGCTC CACACTGAAT 660
CCTCAGTGGA ATGAGTCCTT CACGTTCAAA TTAAAACCTT CAGACAAAGA CCGGCGACTG 720
TCTGTAGAAA TCTGGGACTG GGATCGGACG ACTCGGAATG ACTTCATGGG ATCCCTTTCC 780
TTTGGTGTCT CAGAGCTAAT GAAGATGCCG GCCAGTGGAT GGTATAAACT GCTCAACCAA 840
GAAGAGGGCG AATACTACAA TGTGCCCATT CCAGAAGGAG ATGAAGAAGG CAACATGGAA 900
CTCAGGCAGA AGTTTGAGAA AGCCAAGCTA GGCCCTGCTG GTAACAAAGT CATCAGCCCT 960
TCAGAAGACA GAAAGCAACC ATCCAACAAC CTGGACAGAG TGAAACTCAC AGACTTCAAC 1020
TTCCTCATGG TGCTGGGGAA GGGGAGTTTT GGGAAGGTGA TGCTTGCTGA CAGGAAGGGA 1080
ACGGAGGAAC TGTACGCCAT CAAGATCCTG AAGAAGGACG TGGTGATCCA GGACGACGAC 1140
GTGGAGTGCA CCATGGTGGA GAAGCGCGTG CTGGCCCTGC TGGACAAGCC GCCATTTCTG 1200
ACACAGCTGC ACTCCTGCTT CCAGACAGTG GACCGGCTGT ACTTCGTCAT GGAATACGTC 1260
AACGGCGGGG ACCTCATGTA CCACATTCAG CAAGTCGGGA AATTTAAGGA GCCACAAGCA 1320
GTATTCTACG CAGCCGAGAT CTCCATCGGA CTGTTCTTCC TTCATAAAAG AGGGATCATT 1380
TACAGGGATC TGAAGCTGGA CAATGTCATG CTGGACTCAG AAGGGCACAT CAAAATCGCC 1440
GACTTTGGGA TGTGCAAGGA ACACATGATG GATGGAGTCA CGACCAGGAC CTTCTGTGGG 1500
ACTCCGGACT ACATTGCCCC AGAGATAATC GCTTACCAGC CGTACGGGAA GTCTGTAGAT 1560
TGGTGGGCGT ACGGTGTGCT GCTGTACGAG ATGCTAGCCG GGCAGCCTCC GTTTGATGGT 1620
GAAGATGAAG ATGAACTGTT TCAGTCTATA ATGGAGCACA ACGTGTCCTA CCCCAAATCC 1680
TTGTCCAAGG AAGCCGTCTC TATCTGCAAA GGACTTATGA CCAAACACCC TGCCAAGCGG 1740
CTGGGCTGCG GGCCCGAGGG AGAGAGGGAT GTCAGAGAGC ATGCCTTCTT CAGGAGAATC 1800
GACTGGGAGA AACTGGAGAA CAGGGAGATC CAACCACCAT TCAAGCCCAA AGTGTGTGGC 1860
AAAGGAGCAG AAAACTTTGA CAAGTTCTTC ACGCGAGGAC AGCCTGTCTT AACACCACCA 1920
GATCAGCTGG TCATTGCTAA CATAGACCAA TCTGATTTTG AAGGGTTCTC GTATGTCAAC 1980
CCCCAGTTTG TGCACCCAAT CTTGCAAAGT GCAGTATGA 2019
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 339   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  398
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 399   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  458
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 459   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  518
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+
Q: 519   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  578
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+d++ehaff
Q: 579   KRLGCGPEGERDVREHAFF  597
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240
KRLGCGPEGE RDVREHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAE-00131
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PAT-00160
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-XIM-00207
Gene Ontology
GO:0005829; C:cytosol
GO:0030425; C:dendrite
GO:0005783; C:endoplasmic reticulum
GO:0045121; C:membrane raft
GO:0005739; C:mitochondrion
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0001750; C:photoreceptor outer segment
GO:0005886; C:plasma membrane
GO:0043234; C:protein complex
GO:0005524; F:ATP binding
GO:0004698; F:calcium-dependent protein kinase C activity
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0008270; F:zinc ion binding
GO:0007568; P:aging
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0021955; P:central nervous system neuron axonogenesis
GO:0002062; P:chondrocyte differentiation
GO:0000188; P:inactivation of MAPK activity
GO:0050930; P:induction of positive chemotaxis
GO:0097193; P:intrinsic apoptotic signaling pathway
GO:0007611; P:learning or memory
GO:0008285; P:negative regulation of cell proliferation
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046325; P:negative regulation of glucose import
GO:0045822; P:negative regulation of heart contraction
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0017148; P:negative regulation of translation
GO:0030593; P:neutrophil chemotaxis
GO:0018105; P:peptidyl-serine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0045785; P:positive regulation of cell adhesion
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0045921; P:positive regulation of exocytosis
GO:0050729; P:positive regulation of inflammatory response
GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0001934; P:positive regulation of protein phosphorylation
GO:0048661; P:positive regulation of smooth muscle cell proliferation
GO:0051965; P:positive regulation of synapse assembly
GO:0006937; P:regulation of muscle contraction
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330; P:regulation of platelet aggregation
GO:0048259; P:regulation of receptor-mediated endocytosis
GO:0002026; P:regulation of the force of heart contraction
GO:0046677; P:response to antibiotic
GO:0051412; P:response to corticosterone stimulus
GO:0032355; P:response to estradiol stimulus
GO:0045471; P:response to ethanol
GO:0070555; P:response to interleukin-1
GO:0009612; P:response to mechanical stimulus
GO:0043434; P:response to peptide hormone stimulus
GO:0000302; P:response to reactive oxygen species
KEGG
mmu:18750;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013