EKS-MUM-00424

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00424

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	334.6	1.3E-99	1044	1307	264

Status

Unreviewed

Ensembl Protein

ENSMUSP00000056254

UniProt Accession

E9Q3S4;

Protein Name

Protein Synonyms/Alias

Protein Ysk4;

Gene Name

Ysk4

Gene Synonyms/Alias

Ysk4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000051590	ENSMUSP00000056254	ENSMUST00000061512

Organism

Mus musculus

Functional Description

Protein Length

1311

Protein Sequence
(FASTA)

MDSMPRPERH AESLLDICHE AGSTPMEMTV SQTENLTLQS ISSSEDFDLE DDFSPFILAR 60

EGAAPRGENW PRRTEGVEII VTFPPDPLQE ASQEDLKESN QVTSEHQERE QVHPVSPPDD 120

AEMVGLTGRM LTTQPSLLKT DGSSEELCGV DVALSPPRPC LDSSLAASAA GEVAPCVLKE 180

QQRQSDEFPT SDISYSSRRT GLPLPPLSCL PMRSCIFNME KSPKSPRHRE RKVPSLSLSV 240

PKLLEPLSRP LSQSAEFSSS KNHQEVTQEG PVEHTLRGSN CTLWSRNMCS FRKSGKQGVA 300

ESWPSQEMEG WDKTKTSGFK EGPSLFSCES VKEDTTPTER ERDSGYHVSE MQRGGEDSQY 360

LSSRKKESWT ARVVERDSGV EHPILCKLLE VSNSEMTPAE EKEIGNENVP DAKSNSVHKS 420

GAMEPHAASE EVSVPKNGPS VNSDGPAEEL EGHRDIEQNR KIPMEEETNP EMNGVVPLTH 480

IAFPGEGTSK GPARAEPHLQ RRKRPAQNSN SFNLLAHREH DKLQTNTHRT KLDSRTKARN 540

RAPPNLMVSI QASIKPNMHK NSIKTQVFPA LELIDHRPHP SSKFQRRAPL TEKKSTHQTQ 600

KPKKQAFPRI GKHAGIKKPG IPLSAETTDP RLHFLDLKYS DMFKEINSAS NGPGIYEMFG 660

TPVYCHIREA ERHDHRCYRE IRTAPSGRCV VNKCQSSESD RCSNSRARLL QKRQHIKPPK 720

PLHGLRQKHR GFISKDKGCK DMGGHTEDSV SEPDGQMKSP GNDFLSSKDD AQLMHLIPIP 780

ELSPEQKAPA PVSDLSIVEE IFTEECADEE GILNDDSLTQ SLGDLKEPEG LHPQAPLVPS 840

ENSWAVLSEK RSGKRVSPEK HNVEPLDKIN AEQMFPGYLE FDSLSEKSKT LVSFSSCSFQ 900

ENLERAPSPT EQHWARSLEQ DSLENNSTTY QTFGKISQEI LDPGKNEELT DELLGCLVEE 960

LLALDEKDNN SCQIMTNEAD AKNLNLVFSR RGNTIEELGR ETTDVKLQRC INGFRIYDEE 1020

NFLTSNEKKT LSDKSLNHEE AIFWTKGEIL GRGAYGTVYC GLTSLGQLIA VKQVALDTSD 1080

KLATEKEYRK LQEEVDLLKA LKHVNIVAYL GTCLEENTLS IFMEFVPGGS ISSIINRFGP 1140

LPEMVFCKYT RQILQGVAYL HDNCVVHRDI KGNNVMLMPT GIIKLIDFGC AKRLAWAGLN 1200

GTHSDMLKSM RGTPYWMAPE VINESGYGRK SDIWSIGCTV FEMATGKPPL ASMDRMAAMF 1260

YIGAHRGLMP PLPARFSEPA ADFVRLCLTR DQHERPSALQ LLKHSFLKRS Q 1311

Nucleotide Sequence
(FASTA)

ATGGATTCTA TGCCCAGACC AGAAAGACAT GCCGAGTCAC TGCTTGACAT CTGTCATGAG 60

GCAGGCTCTA CTCCAATGGA GATGACAGTT TCCCAAACTG AAAACCTCAC CTTGCAGAGC 120

ATCAGCAGCA GTGAGGACTT TGACCTTGAA GATGACTTCA GCCCGTTCAT ATTGGCTAGG 180

GAAGGAGCAG CTCCCAGGGG TGAAAACTGG CCACGAAGGA CAGAAGGTGT GGAGATTATT 240

GTGACGTTTC CACCGGATCC TCTCCAAGAA GCAAGCCAAG AAGACTTGAA AGAAAGCAAT 300

CAGGTGACTT CAGAGCATCA GGAACGGGAA CAAGTGCATC CTGTCTCTCC ACCAGATGAC 360

GCGGAGATGG TGGGCCTCAC GGGGAGGATG CTAACCACAC AGCCTTCACT TCTGAAGACA 420

GACGGAAGTT CTGAGGAGCT CTGTGGTGTG GACGTGGCTC TCTCACCACC CAGACCTTGC 480

TTAGACTCAA GCCTTGCTGC ATCTGCAGCT GGGGAGGTGG CTCCTTGTGT TCTGAAAGAA 540

CAGCAAAGGC AATCTGATGA GTTTCCTACC TCTGACATAA GCTACAGTAG CCGAAGAACT 600

GGGCTTCCTC TGCCACCACT ATCATGCTTG CCCATGAGAT CTTGTATCTT CAATATGGAA 660

AAAAGCCCCA AGTCCCCAAG GCACAGGGAA AGAAAGGTCC CCAGCCTCAG CCTGTCTGTG 720

CCTAAGCTCC TGGAACCTCT TAGCCGACCT CTTAGCCAAT CTGCAGAGTT TAGTTCATCA 780

AAGAACCATC AAGAAGTCAC GCAGGAAGGA CCAGTGGAAC ACACCCTCAG GGGTTCTAAC 840

TGTACCCTCT GGTCCAGAAA CATGTGTTCT TTCCGGAAGA GCGGAAAACA GGGAGTAGCG 900

GAGAGTTGGC CATCCCAGGA AATGGAAGGG TGGGACAAAA CTAAAACCTC TGGCTTCAAA 960

GAAGGGCCAT CTTTGTTCTC TTGTGAGAGT GTCAAAGAAG ACACTACTCC TACAGAGAGG 1020

GAAAGGGATA GTGGGTACCA TGTTAGTGAG ATGCAAAGAG GGGGAGAGGA CTCCCAATAT 1080

CTTTCATCAA GAAAAAAAGA GAGTTGGACA GCCAGAGTGG TTGAGCGAGA TTCAGGGGTT 1140

GAGCACCCCA TTCTCTGCAA GCTCCTGGAA GTCTCAAATT CAGAAATGAC CCCAGCAGAG 1200

GAGAAAGAGA TCGGAAATGA GAACGTTCCT GATGCCAAAA GCAATTCTGT ACACAAATCT 1260

GGAGCAATGG AGCCACATGC AGCGTCAGAA GAGGTTAGTG TTCCTAAGAA TGGTCCCAGT 1320

GTGAACTCTG ACGGCCCTGC TGAAGAGCTG GAAGGTCATA GAGACATAGA ACAGAACAGA 1380

AAAATACCAA TGGAGGAAGA AACAAATCCC GAAATGAATG GGGTGGTGCC GCTTACTCAC 1440

ATCGCATTCC CTGGAGAAGG GACATCCAAG GGACCCGCTA GAGCCGAACC ACACCTCCAA 1500

AGGAGAAAGC GCCCGGCGCA GAACAGCAAC AGCTTCAACC TGCTTGCTCA CCGAGAACAC 1560

GACAAACTCC AGACAAATAC TCATAGAACC AAGTTGGATT CAAGGACCAA GGCCAGGAAC 1620

AGAGCACCCC CTAATCTCAT GGTTTCCATC CAAGCATCCA TTAAGCCCAA CATGCATAAA 1680

AACAGCATAA AAACTCAAGT TTTCCCTGCT TTGGAACTTA TAGACCACAG ACCTCATCCC 1740

TCCTCCAAGT TTCAAAGGAG AGCACCTCTG ACAGAAAAGA AGTCAACGCA TCAGACCCAG 1800

AAACCTAAAA AGCAAGCATT TCCTCGAATC GGTAAACATG CAGGCATAAA AAAGCCAGGC 1860

ATTCCCCTCT CCGCTGAAAC AACAGATCCG AGACTGCACT TCCTGGATTT GAAGTACAGT 1920

GACATGTTCA AAGAAATCAA CTCAGCCTCC AACGGACCAG GCATCTATGA GATGTTTGGA 1980

ACCCCTGTTT ATTGTCACAT TCGCGAGGCA GAAAGGCACG ACCACAGATG TTACCGTGAG 2040

ATACGTACGG CTCCATCAGG CCGATGTGTC GTTAATAAAT GCCAGTCTTC CGAAAGTGAC 2100

AGGTGCAGCA ACAGCAGGGC AAGACTTCTT CAGAAGAGAC AACACATTAA ACCCCCAAAG 2160

CCATTGCATG GTCTCAGGCA AAAGCACAGA GGGTTCATTT CTAAAGACAA AGGTTGCAAG 2220

GATATGGGGG GCCATACAGA GGATAGCGTT TCAGAACCTG ATGGGCAGAT GAAATCTCCA 2280

GGAAATGACT TTCTATCTTC CAAAGATGAC GCTCAACTCA TGCACTTGAT CCCCATCCCT 2340

GAACTGTCCC CCGAACAGAA AGCACCCGCT CCAGTCTCAG ATCTATCCAT TGTTGAGGAA 2400

ATCTTCACAG AGGAGTGTGC AGACGAAGAA GGCATTCTCA ACGATGACAG CCTTACCCAA 2460

AGCCTTGGCG ATCTGAAAGA GCCTGAAGGG TTGCACCCCC AGGCCCCTCT CGTTCCTTCA 2520

GAAAACAGCT GGGCTGTGCT TAGCGAGAAG CGTTCGGGCA AGCGTGTGTC TCCAGAAAAG 2580

CACAATGTAG AACCTCTTGA TAAAATAAAT GCTGAGCAGA TGTTCCCGGG TTACCTGGAG 2640

TTTGATAGCC TTTCAGAGAA GTCTAAAACA CTGGTGAGCT TTTCCAGTTG CTCTTTCCAG 2700

GAGAACCTGG AAAGAGCCCC TTCCCCTACA GAACAACACT GGGCACGTTC TTTGGAGCAG 2760

GACAGCTTAG AAAATAACTC CACCACATAC CAGACATTTG GAAAGATTTC CCAGGAAATC 2820

TTAGACCCAG GAAAGAATGA AGAGTTGACA GACGAGTTGC TGGGTTGTCT AGTTGAAGAA 2880

CTGTTAGCAC TCGATGAGAA AGATAACAAC TCTTGCCAAA TAATGACAAA TGAGGCAGAC 2940

GCCAAAAACC TGAATCTTGT CTTCAGCAGG AGAGGCAATA CCATCGAAGA ACTGGGCAGA 3000

GAGACAACAG ATGTCAAACT TCAGAGGTGT ATTAATGGAT TCCGGATATA TGATGAGGAA 3060

AACTTTCTTA CCTCAAATGA AAAGAAGACA CTTTCTGACA AGAGCTTAAA CCACGAAGAG 3120

GCTATCTTCT GGACCAAGGG TGAGATCCTT GGGAGAGGAG CCTATGGCAC AGTATACTGT 3180

GGGCTCACCA GCCTAGGGCA GCTAATAGCT GTAAAACAGG TGGCCTTGGA TACTTCTGAT 3240

AAACTGGCTA CCGAGAAGGA ATACCGGAAA CTGCAGGAGG AAGTGGATTT GCTGAAGGCA 3300

CTGAAGCATG TCAACATAGT AGCTTATCTA GGGACGTGCT TGGAGGAGAA CACTCTGAGC 3360

ATCTTCATGG AATTTGTCCC TGGTGGTTCC ATCTCTAGTA TAATAAACCG CTTTGGGCCA 3420

CTGCCTGAGA TGGTGTTCTG TAAATACACA AGACAGATCC TGCAAGGTGT TGCCTATCTC 3480

CATGACAACT GTGTGGTACA TCGAGATATC AAAGGGAACA ACGTCATGCT CATGCCAACG 3540

GGAATAATAA AGTTGATTGA CTTCGGCTGT GCCAAGCGTT TGGCCTGGGC AGGCTTAAAT 3600

GGTACCCACA GTGACATGCT CAAGTCCATG CGTGGGACTC CATACTGGAT GGCCCCGGAG 3660

GTCATCAATG AGTCTGGCTA TGGAAGGAAA TCAGATATAT GGAGCATTGG CTGCACCGTG 3720

TTCGAGATGG CCACAGGGAA GCCTCCTTTG GCTTCCATGG ATAGGATGGC AGCCATGTTC 3780

TACATTGGAG CCCACAGAGG CCTAATGCCT CCTCTACCTG CCCGATTCTC AGAACCTGCT 3840

GCGGACTTCG TGCGTTTGTG CCTGACCAGG GACCAGCATG AGAGACCTTC TGCTCTCCAG 3900

CTCTTGAAGC ACTCCTTCCT GAAGAGAAGC CAGTGA 3936

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikp.ekksekkevkalkeEikllkelk  59

         w+k+e++g+G++g+vy++l+ + g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 1044  WTKGEILGRGAYGTVYCGLT-SLGQLIAVKQVALDTsDKLATEKEYRKLQEEVDLLKALK  1102

         89****************98.99***********8614556778****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee++l+if+E+v+gGs+ss+++++g+l e+v++kyt+qil+g+ayLH+

Q: 1103  HVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHD  1162

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1163  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMRGTPYWMAPEVI  1222

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p ++se

Q: 1223  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPARFSEP  1279

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1280  AADFVRLCLTRDQHERPSALQLLKHSFL  1307

         **************************96

Domain Sequence
(FASTA)

WTKGEILGRG AYGTVYCGLT SLGQLIAVKQ VALDTSDKLA TEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LEENTLSIFM EFVPGGSISS IINRFGPLPE MVFCKYTRQI LQGVAYLHDN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMRGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP ARFSEPAADF 240

VRLCLTRDQH ERPSALQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mmu:22625

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013