EKS-MUM-00313

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00313

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	1.5E-125	192	478	287

Status

Reviewed

Ensembl Protein

ENSMUSP00000067305

UniProt Accession

P27038;

Protein Name

Activin receptor type-2A

Protein Synonyms/Alias

Activin receptor type IIA; ACTR-IIA;

Gene Name

Acvr2a

Gene Synonyms/Alias

Acvr2a; Acvr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000052155	ENSMUSP00000067305	ENSMUST00000063886

Organism

Mus musculus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120

EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 60

ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 120

AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 180

TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 300

TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 360

GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 420

CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 480

TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAAGA CCCAGGACCA 540

CCCCCACCTT CCCCATTACT AGGGTTGAAG CCATTGCAGC TGTTAGAAGT GAAAGCAAGG 600

GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTCAATG AATATGTGGC TGTCAAAATA 660

TTTCCAATAC AGGACAAACA GTCCTGGCAG AATGAATATG AAGTCTATAG TCTACCTGGA 720

ATGAAGCATG AGAACATACT ACAGTTCATT GGTGCAGAGA AAAGAGGCAC CAGTGTGGAT 780

GTGGACCTGT GGCTAATCAC AGCATTTCAT GAAAAGGGCT CACTGTCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAACTTTGT CATATTGCAG AAACCATGGC TAGAGGATTG 900

GCATATTTAC ATGAGGATAT ACCTGGCTTA AAAGATGGCC ACAAGCCTGC AATCTCTCAC 960

AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACAGCTTG CATTGCTGAC 1020

TTTGGGTTGG CCTTAAAGTT CGAGGCTGGC AAGTCTGCAG GTGACACCCA TGGGCAGGTT 1080

GGTACCCGGA GGTATATGGC TCCAGAGGTG TTGGAGGGTG CTATAAACTT CCAAAGGGAC 1140

GCATTTCTGA GGATAGATAT GTACGCCATG GGATTAGTCC TATGGGAATT GGCTTCTCGT 1200

TGCACTGCTG CAGATGGACC CGTAGATGAG TACATGTTAC CATTTGAGGA AGAAATTGGC 1260

CAGCATCCAT CTCTTGAAGA TATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 1320

TTAAGAGATT ATTGGCAGAA ACATGCAGGA ATGGCAATGC TCTGTGAAAC GATAGAAGAA 1380

TGTTGGGATC ATGATGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 1440

CAGATGCAAA GACTAACAAA TATCATTACT ACAGAGGACA TTGTAACAGT GGTCACAATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

3D-structure; ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0016362	; F:activin receptor activity, type II
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0019838	; F:growth factor binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048706	; P:embryonic skeletal system development
GO:0001702	; P:gastrulation with mouth forming second
GO:0007498	; P:mesoderm development
GO:0043084	; P:penile erection
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046881	; P:positive regulation of follicle-stimulating hormone secretion
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0010033	; P:response to organic substance
GO:0060011	; P:Sertoli cell proliferation
GO:0023014	; P:signal transduction by phosphorylation
GO:0042713	; P:sperm ejaculation
GO:0007283	; P:spermatogenesis

KEGG

mmu:11480

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013