EKS-MUM-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.5	2.8E-135	204	491	288

Status

Reviewed

Ensembl Protein

ENSMUSP00000029948

UniProt Accession

P36898; Q3TRF2;

Protein Name

Bone morphogenetic protein receptor type-1B

Protein Synonyms/Alias

BMP type-1B receptor; BMPR-1B; Activin receptor-like kinase 6; ALK-6; Serine/threonine-protein kinase receptor R6; SKR6;

Gene Name

Bmpr1b

Gene Synonyms/Alias

Bmpr1b; Acvrlk6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000052430	ENSMUSP00000096167	ENSMUST00000098568
ENSMUSG00000052430	ENSMUSP00000029948	ENSMUST00000029948
ENSMUSG00000052430	ENSMUSP00000101839	ENSMUST00000106232
ENSMUSG00000052430	ENSMUSP00000101837	ENSMUST00000106230
ENSMUSG00000052430	ENSMUSP00000117478	ENSMUST00000131273

Organism

Mus musculus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.

Protein Length

502

Protein Sequence
(FASTA)

MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKDRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCMKKLR PSFPNRWSSD ECLRQMGKLM TECWAQNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTCTTAC GAAGCTCTGG AAAATTAAAT GTGGGCACCA AGAAGGAGGA TGGAGAGAGT 60

ACAGCCCCCA CCCCTCGGCC CAAGATCCTA CGTTGTAAAT GCCACCACCA CTGTCCGGAA 120

GACTCAGTCA ACAATATCTG CAGCACAGAT GGGTACTGCT TCACGATGAT AGAAGAAGAT 180

GACTCTGGAA TGCCTGTTGT CACCTCTGGA TGTCTAGGAC TAGAAGGGTC AGATTTTCAA 240

TGTCGTGACA CTCCCATTCC TCATCAAAGA AGATCAATTG AATGCTGCAC AGAAAGGAAT 300

GAGTGTAATA AAGACCTCCA CCCCACTCTG CCTCCTCTCA AGGACAGAGA TTTTGTTGAT 360

GGGCCCATAC ACCACAAGGC CTTGCTTATC TCTGTGACTG TCTGTAGTTT ACTCTTGGTC 420

CTCATTATTT TATTCTGTTA CTTCAGGTAT AAAAGACAAG AAGCCCGACC TCGGTACAGC 480

ATTGGGCTGG AGCAGGACGA GACATACATT CCTCCTGGAG AGTCCCTGAG AGACTTGATC 540

GAGCAGTCTC AGAGCTCGGG AAGTGGATCA GGCCTCCCTC TGCTGGTCCA AAGGACAATA 600

GCTAAGCAAA TTCAGATGGT GAAGCAGATT GGAAAAGGCC GCTATGGCGA GGTGTGGATG 660

GGAAAGTGGC GTGGAGAAAA GGTGGCTGTG AAAGTGTTCT TCACCACGGA GGAAGCCAGC 720

TGGTTCCGAG AGACTGAGAT ATATCAGACG GTCCTGATGC GGCATGAGAA TATTCTGGGG 780

TTCATTGCTG CAGATATCAA AGGGACTGGG TCCTGGACTC AGTTGTACCT CATCACAGAC 840

TATCATGAAA ACGGCTCCCT TTATGACTAT CTGAAATCCA CCACCTTAGA CGCAAAGTCC 900

ATGCTGAAGC TAGCCTACTC CTCTGTCAGC GGCCTATGCC ATTTACACAC GGAAATCTTT 960

AGCACTCAAG GCAAGCCAGC AATCGCCCAT CGAGACTTGA AAAGTAAAAA CATCCTGGTG 1020

AAGAAAAATG GAACTTGCTG CATAGCAGAC CTGGGCTTGG CTGTCAAGTT CATTAGTGAC 1080

ACAAATGAGG TTGACATCCC ACCCAACACC CGGGTTGGCA CCAAGCGCTA TATGCCTCCA 1140

GAAGTGCTGG ACGAGAGCTT GAATAGAAAC CATTTCCAGT CCTACATTAT GGCTGACATG 1200

TACAGCTTTG GACTCATCCT CTGGGAGATT GCAAGGAGAT GTGTTTCTGG AGGTATAGTG 1260

GAAGAATACC AGCTTCCCTA TCACGACCTG GTGCCCAGTG ACCCTTCTTA TGAGGACATG 1320

AGAGAAATTG TGTGCATGAA GAAGTTACGG CCTTCATTCC CCAATCGATG GAGCAGTGAT 1380

GAGTGTCTCA GGCAGATGGG GAAGCTTATG ACAGAGTGCT GGGCGCAGAA TCCTGCCTCC 1440

AGGCTGACGG CCCTGAGAGT TAAGAAAACC CTTGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAACTCTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v++kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDAKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEIARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCMKKLRPSF PNRWSSDECL RQMGKLMTEC WAQNPASRLT ALRVKKTL 288

Keyword

3D-structure; ATP-binding; Chondrogenesis; Complete proteome; Disulfide bond; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030425	; C:dendrite
GO:0016021	; C:integral to membrane
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006703	; P:estrogen biosynthetic process
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

mmu:12167

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013