EKS-MUM-00152
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00152
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.93.0E-167448724277
StatusUnreviewed
Ensembl ProteinENSMUSP00000085122
UniProt AccessionE9QNJ9;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFgfr3
Gene Synonyms/Alias Fgfr3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000054252ENSMUSP00000110053ENSMUST00000114411
ENSMUSG00000054252ENSMUSP00000133064ENSMUST00000164207
ENSMUSG00000054252ENSMUSP00000119941ENSMUST00000155002
ENSMUSG00000054252ENSMUSP00000130856ENSMUST00000169212
ENSMUSG00000054252ENSMUSP00000085122ENSMUST00000087820
ENSMUSG00000054252ENSMUSP00000070998ENSMUST00000067150
ENSMUSG00000054252ENSMUSP00000131845ENSMUST00000171509
OrganismMus musculus
Functional Description
Protein Length782
Protein Sequence
(FASTA)
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG SGDTVELSCH 60
PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE DAGVYSCQHR LTRRVLCHFS 120
VRVTGAPYWT RPERMDKKLL AVPAANTVRF RCPAAGNPTP SISWLKNGKE FRGEHRIGGI 180
KLRHQQWSLV MESVVPSDRG NYTCVVENKF GSIRQTYTLD VLERSPHRPI LQAGLPANQT 240
AILGSDVEFH CKVYSDAQPH IQWLKHVEVN GSKVGPDGTP YVTVLKTAGA NTTDKELEVL 300
SLHNVTFEDA GEYTCLAGNS IGFSHHSAWL VVLPAEEELM ETDEAGSVYA GVLSYGVVFF 360
LFILVVAAVI LCRLRSPPKK GLGSPTVHKV SRFPLKRQVS LESNSSMNSN TPLVRIARLS 420
SGEGPVLANV SELELPADPK WELSRTRLTL GKPLGEGCFG QVVMAEAIGI DKDRTAKPVT 480
VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQGGPLYVL VEYAAKGNLR 540
EFLRARRPPG MDYSFDACRL PEEQLTCKDL VSCAYQVARG MEYLASQKCI HRDLAARNVL 600
VTEDNVMKIA DFGLARDVHN LDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLL 660
WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPASCTHDLY MIMRECWHAV PSQRPTFKQL 720
VEDLDRILTV TSTDEYLDLS VPFEQYSPGG QDTPSSSSSG DDSVFTHDLL PPGPPSNGGP 780
RT 782
Nucleotide Sequence
(FASTA)
ATGGTAGTCC CGGCCTGCGT GCTAGTGTTC TGCGTGGCGG TCGTGGCTGG AGCTACTTCC 60
GAGCCTCCTG GTCCAGAGCA GCGAGTTGTG CGGAGAGCGG CAGAGGTTCC AGGGCCTGAA 120
CCTAGCCAGC AGGAGCAGGT GGCCTTCGGC AGTGGGGACA CCGTGGAGCT GAGCTGCCAT 180
CCTCCTGGAG GTGCCCCCAC AGGGCCCACG GTCTGGGCTA AGGATGGTAC AGGTCTGGTG 240
GCCTCCCACC GCATCCTGGT GGGGCCTCAG AGGCTGCAAG TGCTAAATGC CTCCCACGAA 300
GATGCAGGGG TCTACAGCTG CCAGCACCGG CTCACTCGGC GTGTGCTGTG CCACTTCAGT 360
GTGCGTGTAA CAGGGGCTCC TTATTGGACT CGCCCGGAGC GAATGGATAA GAAACTGCTG 420
GCTGTGCCAG CCGCAAACAC TGTCCGCTTC CGCTGCCCAG CTGCTGGCAA CCCTACCCCC 480
TCCATCTCCT GGCTGAAGAA TGGCAAAGAA TTCCGAGGGG AGCATCGCAT TGGGGGCATC 540
AAGCTCCGGC ACCAGCAGTG GAGCTTGGTC ATGGAAAGTG TGGTACCCTC CGATCGTGGC 600
AACTATACCT GTGTAGTTGA GAACAAGTTT GGCAGCATCC GGCAGACATA CACACTGGAT 660
GTGCTGGAGC GCTCCCCACA CCGGCCCATC CTGCAGGCTG GGCTGCCGGC CAACCAGACA 720
GCCATTCTAG GCAGTGACGT GGAGTTCCAC TGCAAGGTGT ACAGCGATGC ACAGCCACAC 780
ATCCAGTGGC TGAAGCACGT GGAAGTGAAC GGCAGCAAGG TGGGCCCTGA CGGCACGCCC 840
TACGTCACTG TACTCAAGAC TGCAGGCGCT AACACCACCG ACAAGGAGCT AGAGGTTCTG 900
TCCTTGCACA ATGTCACCTT TGAGGACGCG GGGGAGTACA CCTGCCTGGC GGGCAATTCT 960
ATTGGGTTTT CCCATCACTC TGCGTGGCTG GTGGTGCTGC CAGCTGAGGA GGAGCTGATG 1020
GAAACTGATG AGGCTGGCAG CGTGTACGCA GGCGTCCTCA GCTACGGGGT GGTCTTCTTC 1080
CTCTTCATCC TGGTGGTGGC AGCTGTGATA CTCTGCCGCC TGCGCAGTCC CCCAAAGAAG 1140
GGCTTGGGCT CGCCCACCGT GCACAAGGTC TCTCGCTTCC CGCTTAAGCG ACAGGTGTCC 1200
TTGGAATCTA ACTCCTCTAT GAACTCCAAC ACACCCCTTG TCCGGATTGC CCGGCTGTCC 1260
TCAGGAGAAG GTCCTGTTCT GGCCAATGTT TCTGAACTTG AGCTGCCTGC TGACCCCAAG 1320
TGGGAGCTAT CCAGGACCCG GCTGACACTT GGTAAGCCTC TTGGAGAAGG CTGCTTTGGA 1380
CAGGTGGTCA TGGCAGAAGC TATTGGCATC GACAAGGACC GTACTGCCAA GCCTGTCACC 1440
GTGGCCGTGA AGATGCTGAA AGATGATGCG ACTGACAAGG ACCTGTCGGA CCTGGTATCT 1500
GAGATGGAGA TGATGAAAAT GATTGGCAAG CACAAGAACA TCATTAACCT GCTGGGGGCG 1560
TGCACACAGG GTGGGCCCCT GTATGTGCTG GTGGAGTACG CAGCCAAGGG CAATCTCCGG 1620
GAGTTCCTTC GGGCGCGGCG GCCTCCAGGC ATGGACTACT CCTTTGATGC CTGCAGGCTG 1680
CCAGAGGAAC AGCTCACCTG CAAGGATCTA GTGTCCTGTG CCTACCAGGT GGCACGGGGC 1740
ATGGAATACT TGGCTTCTCA GAAGTGTATT CACAGAGACT TGGCTGCCAG AAACGTCCTG 1800
GTGACCGAGG ACAATGTGAT GAAGATTGCG GACTTTGGCC TGGCTCGAGA TGTGCACAAC 1860
CTGGACTACT ACAAGAAGAC CACAAATGGC CGGCTACCTG TGAAGTGGAT GGCACCAGAG 1920
GCCCTTTTTG ACCGAGTCTA CACCCACCAG AGTGATGTTT GGTCTTTTGG TGTCCTCCTC 1980
TGGGAGATCT TTACGCTGGG GGGCTCACCG TATCCTGGCA TCCCAGTGGA AGAGCTTTTC 2040
AAGCTGTTGA AAGAGGGCCA CCGCATGGAC AAGCCAGCCA GCTGCACACA TGACCTGTAC 2100
ATGATCATGC GGGAATGTTG GCATGCGGTG CCTTCACAGA GGCCCACCTT CAAGCAGTTG 2160
GTAGAGGATT TAGACCGCAT CCTCACTGTG ACATCAACCG ACGAGTACTT GGACCTCTCC 2220
GTGCCGTTTG AGCAGTACTC GCCAGGTGGC CAGGACACGC CTAGCTCCAG CTCGTCCGGA 2280
GATGACTCGG TGTTCACCCA TGACCTGCTA CCCCCAGGTC CACCCAGTAA CGGGGGACCT 2340
CGGACGTGA 2349
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+
Q: 448   LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  507
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veyaakGnlreflrarrp+g+++s d+++ +eeqlt+
Q: 508   IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTC  567
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt
Q: 568   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  627
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 628   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  687
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 688   RMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  724
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDRTAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQGGPL YVLVEYAAKG NLREFLRARR PPGMDYSFDA CRLPEEQLTC 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPASCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-CII-00090
EKS-DAR-00435
EKS-DRM-00072
EKS-EQC-00146
EKS-GAM-00077
EKS-GAG-00124
EKS-GAA-00174
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUP-00153
EKS-NOL-00141
EKS-ORN-00181
EKS-ORA-00127
EKS-ORC-00138
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PEM-00080
EKS-PTV-00141
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0061144; P:alveolar secondary septum development
GO:0060385; P:axonogenesis involved in innervation
GO:0060349; P:bone morphogenesis
GO:0051216; P:cartilage development
GO:0022010; P:central nervous system myelination
GO:0090102; P:cochlea development
GO:0048546; P:digestive tract morphogenesis
GO:0072148; P:epithelial cell fate commitment
GO:0060113; P:inner ear receptor cell differentiation
GO:0070307; P:lens fiber cell development
GO:0002089; P:lens morphogenesis in camera-type eye
GO:0000165; P:MAPK cascade
GO:0002009; P:morphogenesis of an epithelium
GO:0043066; P:negative regulation of apoptotic process
GO:0048712; P:negative regulation of astrocyte differentiation
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
GO:0035019; P:somatic stem cell maintenance
GO:0021762; P:substantia nigra development
KEGG
mmu:14184;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013