| Tag | Content |
|---|
| EKPD ID | EPS-MUM-00014 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 70.2 | 4.1E-19 | 157 | 312 | 156 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000066050 |
| UniProt Accession | Q9WUA5; G5E8E2; Q8BY80; |
| Protein Name | Laforin |
| Protein Synonyms/Alias | Lafora PTPase; LAFPTPase; |
| Gene Name | Epm2a |
| Gene Synonyms/Alias | Epm2a; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Dual specificity protein phosphatase. May be involved inthe control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (By similarity). Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). |
| Protein Length | 330 |
Protein Sequence
(FASTA) | | MLFRFGVVVP PAVAGARQEL LLAGSRPELG RWEPHGAVRL RPAGTAAGAA ALALQEPGLW 60 | | LAEVELEAYE EAGGAEPGRV DTFWYKFLQR EPGGELHWEG NGPHHDRCCT YNEDNLVDGV 120 | | YCLPVGHWIE ATGHTNEMKH TTDFYFNIAG HQAMHYSRIL PNIWLGSCPR QLEHVTIKLK 180 | | HELGVTAVMN FQTEWDIIQN SSGCNRYPEP MTPDTMMKLY KEEGLSYIWM PTPDMSTEGR 240 | | VQMLPQAVCL LHALLENGHT VYVHCNAGVG RSTAAVCGWL HYVIGWNLRK VQYFIMAKRP 300 | | AVYIDEDALA QAQQDFSQKF GKVHSSICAL 330 |
|
Nucleotide Sequence
(FASTA) | | ATGCTCTTCC GCTTCGGCGT GGTGGTGCCG CCCGCGGTGG CCGGCGCTCG GCAGGAGCTG 60 | | CTGCTCGCCG GCTCGCGGCC CGAGTTAGGG CGCTGGGAGC CGCACGGCGC CGTGCGTCTC 120 | | AGGCCCGCGG GTACCGCGGC GGGCGCCGCT GCGCTGGCGC TGCAGGAGCC CGGCCTGTGG 180 | | CTCGCCGAGG TGGAGCTGGA GGCGTACGAG GAGGCCGGCG GGGCGGAGCC GGGCCGCGTT 240 | | GACACGTTCT GGTACAAGTT CCTGCAGCGC GAGCCTGGAG GCGAGCTGCA CTGGGAAGGA 300 | | AATGGACCTC ACCATGACCG TTGCTGCACA TATAATGAGG ACAACTTGGT GGATGGTGTT 360 | | TATTGTCTCC CAGTAGGACA CTGGATTGAG GCCACTGGGC ACACCAATGA AATGAAGCAC 420 | | ACAACAGACT TCTATTTTAA TATTGCTGGC CACCAAGCCA TGCACTATTC AAGAATTCTA 480 | | CCAAATATCT GGCTGGGTAG CTGCCCTCGC CAACTGGAAC ATGTGACCAT CAAACTGAAG 540 | | CATGAACTGG GAGTTACAGC TGTCATGAAT TTCCAGACTG AATGGGATAT CATCCAGAAT 600 | | TCTTCAGGCT GCAACCGCTA CCCTGAACCC ATGACTCCAG ACACCATGAT GAAGCTGTAT 660 | | AAGGAAGAAG GCTTGTCCTA CATCTGGATG CCCACTCCAG ACATGAGCAC TGAGGGCCGA 720 | | GTGCAGATGC TGCCACAGGC TGTGTGTCTC CTGCACGCGC TTCTGGAGAA TGGACACACG 780 | | GTGTATGTCC ACTGCAACGC TGGCGTGGGT CGCTCCACAG CTGCAGTGTG CGGCTGGCTC 840 | | CACTATGTGA TTGGCTGGAA TCTGCGCAAG GTGCAGTACT TCATCATGGC CAAGAGGCCT 900 | | GCGGTCTACA TTGACGAGGA CGCTTTGGCT CAAGCACAAC AAGACTTTTC TCAGAAGTTC 960 | | GGGAAGGTTC ACTCTTCCAT ATGCGCTTTG TAG 993 |
|
| Domain Profile | S: 3 teilpglylgdqataldrreLs...klgitvvinaslsvikvq...........viPe.. 46 | ++ilp+++lg+ l++++++ +lg+t v+n ++ +q +P+ | Q: 157 SRILPNIWLGSCPRQLEHVTIKlkhELGVTAVMNFQTEWDIIQnssgcnrypepMTPDtm 216 | 789999999999999999877422357888888865543222211111111122345422 |
| S: 47 ..ylikkgityknipvdDsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlv 104 | ++ ++g +y +p D ++ +q++++a+++++ e+g+ v+vHC+aGv+RS++ v | Q: 217 mkLYKEEGLSYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAAV 276 | 22567899**************************************************** |
| S: 105 laYLmkveglslsdAieavkrkrpsiepnegfleQL 140 | +++L +v g++l+++ +++krp+++ +e+ l+Q | Q: 277 CGWLHYVIGWNLRKVQYFIMAKRPAVYIDEDALAQA 312 | ********************************9995 |
|
Domain Sequence
(FASTA) | | SRILPNIWLG SCPRQLEHVT IKLKHELGVT AVMNFQTEWD IIQNSSGCNR YPEPMTPDTM 60 | | MKLYKEEGLS YIWMPTPDMS TEGRVQMLPQ AVCLLHALLE NGHTVYVHCN AGVGRSTAAV 120 | | CGWLHYVIGW NLRKVQYFIM AKRPAVYIDE DALAQA 156 |
|
| Keyword | Carbohydrate metabolism; Complete proteome; Cytoplasm; Endoplasmic reticulum; Glycogen metabolism; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome; Ubl conjugation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |