EKS-MUM-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	454.0	4.9E-136	4	285	282

Status

Reviewed

Ensembl Protein

ENSMUSP00000068904

UniProt Accession

Q9WVS4; Q8CFU4;

Protein Name

MAPK/MAK/MRK overlapping kinase

Protein Synonyms/Alias

MOK protein kinase; Serine/threonine kinase 30;

Gene Name

Mok

Gene Synonyms/Alias

Mok; Rage, Stk30;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000056458	ENSMUSP00000135791	ENSMUST00000177224
ENSMUSG00000056458	ENSMUSP00000082041	ENSMUST00000084974
ENSMUSG00000056458	ENSMUSP00000068904	ENSMUST00000070565

Organism

Mus musculus

Functional Description

Able to phosphorylate several exogenous substrates andto undergo autophosphorylation.

Protein Length

420

Protein Sequence
(FASTA)

MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQHFE SIEQVNSLRE IQALRRLNPH 60

PNILALHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRHPL SEKKIMLYMY QLCKSLDHMH 120

RNGIFHRDVK PENILVKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT 180

YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PCQKTLTKFK QSRAMSFDFP 240

FKKGSGIPLL TANLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQVQRA AETQTLAKHR 300

RAFCPKFSMV PESSSHNWSF SQEGRKQKQS LRHEEGHARR QGPTSLMELP KLRLSGMTKL 360

SSCSSPALRS VLGTGANGKV PVLRPLKCAA VNKKTDTQKD IKPHLKHYHL PTINRKGGEY 420

Nucleotide Sequence
(FASTA)

ATGAAGAACT ACAAAGCAAT TGGCAAGATA GGAGAGGGGA CGTTTTCTGA AGTTATGAAG 60

ATGCAGAGTC TGAGAGATGG GAATTACTAT GCGTGCAAAC AAATGAAGCA GCACTTTGAA 120

AGTATTGAGC AAGTGAACAG TCTGCGAGAG ATCCAAGCAC TGAGGCGCCT GAACCCACAC 180

CCCAACATCC TTGCACTGCA CGAAGTAGTT TTTGACAGAA AATCTGGTTC TCTTGCACTA 240

ATATGTGAAC TTATGGACAT GAATATTTAT GAGCTAATAC GAGGGAGAAG ACACCCATTA 300

TCAGAGAAAA AGATTATGCT CTACATGTAT CAGCTGTGCA AATCGCTGGA CCACATGCAC 360

AGAAACGGGA TCTTTCACAG AGACGTGAAG CCGGAGAATA TCCTAGTAAA GCAGGATGTC 420

CTGAAACTAG GGGACTTCGG GTCATGCCGG AGTGTCTATT CCAAGCAGCC CTACACAGAG 480

TACATCTCTA CCCGGTGGTA CCGGGCCCCA GAGTGTCTCC TCACCGACGG GTTCTACACA 540

TACAAGATGG ACCTGTGGAG CGCTGGCTGC GTGTTCTACG AGATTGCCAG CCTGCAGCCC 600

CTCTTTCCTG GTGTGAATGA ACTGGACCAG ATCTCAAAAA TCCATGATGT CATCGGCACA 660

CCTTGTCAGA AGACCCTCAC TAAGTTCAAA CAGTCGAGAG CTATGAGTTT TGATTTTCCT 720

TTTAAAAAGG GATCAGGAAT ACCTCTACTG ACAGCCAATT TGTCCCCGCA ATGCCTCTCC 780

CTCCTGCACG CAATGGTGGC TTATGACCCT GACGAACGAA TTGCGGCTCA CCAAGCCCTT 840

CAGCACCCCT ATTTCCAGGT GCAGAGGGCA GCTGAGACAC AGACCCTGGC CAAACACAGA 900

AGAGCTTTCT GTCCCAAGTT CTCCATGGTG CCAGAATCAT CCAGTCACAA CTGGTCATTC 960

TCACAGGAAG GCAGAAAGCA GAAACAGTCC CTGCGGCACG AGGAGGGCCA TGCCAGACGA 1020

CAGGGGCCGA CCAGCTTGAT GGAGCTTCCC AAACTGAGGC TGTCGGGAAT GACCAAACTG 1080

TCATCATGTT CCAGCCCTGC ACTGCGGTCA GTGCTGGGCA CTGGAGCAAA TGGAAAAGTC 1140

CCTGTGCTGA GACCCCTGAA GTGTGCTGCT GTGAACAAGA AGACAGACAC GCAGAAGGAC 1200

ATCAAACCTC ACCTGAAACA CTATCACCTG CCCACGATCA ACAGGAAAGG GGGCGAATAC 1260

TGA 1263

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         yk+i k+G+Gtf+ev++++sl++g+++a+k+mk++fes+e+v++lre+++l++ln+h+ni

Q: 4     YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNSLREIQALRRLNPHPNI  63

         99**********************************************************

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         ++l+ev++dr+++sl+l++elm++n+y+li++rr+ lse+k++ ++yq++k+l+++h++g

Q: 64    LALHEVVFDRKSGSLALICELMDMNIYELIRGRRHPLSEKKIMLYMYQLCKSLDHMHRNG  123

         ************************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         +fhrd+kPenil+k ++++kl+dfG++r+v+sk+Pyt+y+strwyraPe+ll++g+y+++

Q: 124   IFHRDVKPENILVK-QDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYK  182

         **************.*********************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +dlw++Gcv++e+a+l+plfPG++e+dqi+ki++v+GtP++k++++ +k+++a++++fp+

Q: 183   MDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPCQKTLTK-FKQSRAMSFDFPF  241

         **********************************************.*************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         ++gs+++ l++n+s ++l+ll++++aydPder++a+qal++pyf

Q: 242   KKGSGIPLLTANLSPQCLSLLHAMVAYDPDERIAAHQALQHPYF  285

         *******************************************9

Domain Sequence
(FASTA)

YKAIGKIGEG TFSEVMKMQS LRDGNYYACK QMKQHFESIE QVNSLREIQA LRRLNPHPNI 60

LALHEVVFDR KSGSLALICE LMDMNIYELI RGRRHPLSEK KIMLYMYQLC KSLDHMHRNG 120

IFHRDVKPEN ILVKQDVLKL GDFGSCRSVY SKQPYTEYIS TRWYRAPECL LTDGFYTYKM 180

DLWSAGCVFY EIASLQPLFP GVNELDQISK IHDVIGTPCQ KTLTKFKQSR AMSFDFPFKK 240

GSGIPLLTAN LSPQCLSLLH AMVAYDPDER IAAHQALQHP YF 282

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

mmu:26448

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013