| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00508 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/CAMK2 | 587.2 | 8.4E-177 | 14 | 272 | 259 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000065101 |
| UniProt Accession | P28652; Q5SVH9; |
| Protein Name | Calcium/calmodulin-dependent protein kinase type II subunit beta |
| Protein Synonyms/Alias | CaM kinase II subunit beta; CaMK-II subunit beta; |
| Gene Name | Camk2b |
| Gene Synonyms/Alias | Camk2b; Camk2d; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Calcium/calmodulin-dependent protein kinase thatfunctions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. |
| Protein Length | 479 |
Protein Sequence
(FASTA) | | MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 60 | | EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 120 | | LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 180 | | LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 240 | | VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 300 | | KGAILTTMLA TRNFSAAKSL LNKKADGVKE SSDSTNTTIE DEDAKARKQE IIKTTEQLIE 360 | | AVNNGDFEAY AKICDPGLTS FEPEALGNLV EGMDFHRFYF ENLLAKNSKP IHTTILNPHV 420 | | HVIGEDAACI AYIRLTQYID GQGRPRTSQS EETRVWHRRD GKWQNVHFHC SGAPVAPLQ 479 |
|
Nucleotide Sequence
(FASTA) | | ATGGCCACCA CGGTGACCTG CACCCGTTTC ACCGACGAGT ACCAGCTATA CGAGGATATT 60 | | GGCAAGGGGG CTTTCTCTGT GGTCCGACGC TGTGTCAAGC TCTGTACCGG CCATGAGTAT 120 | | GCAGCCAAGA TCATTAATAC CAAGAAGCTG TCGGCCAGAG ATCACCAGAA ACTGGAGAGA 180 | | GAAGCTCGGA TCTGCCGCCT GCTGAAGCAT TCCAACATTG TACGCCTCCA TGACAGCATC 240 | | TCTGAAGAGG GCTTCCACTA CCTGGTCTTC GATCTGGTCA CTGGTGGGGA GCTCTTTGAA 300 | | GACATCGTGG CAAGAGAGTA CTACAGTGAA GCTGATGCCA GTCACTGCAT CCAGCAGATC 360 | | CTGGAAGCTG TTCTCCATTG TCACCAAATG GGGGTCGTCC ACAGAGACCT CAAGCCTGAG 420 | | AACCTGCTTC TGGCCAGCAA ATGCAAAGGC GCCGCAGTGA AGCTGGCAGA CTTCGGCCTG 480 | | GCCATCGAGG TTCAGGGAGA CCAGCAGGCA TGGTTTGGAT TTGCGGGAAC GCCAGGCTAC 540 | | CTGTCTCCCG AGGTCCTTCG GAAGGAGGCC TACGGCAAAC CTGTGGACAT CTGGGCATGT 600 | | GGGGTGATCC TGTATATCCT GCTGGTGGGC TACCCACCTT TCTGGGATGA GGACCAACAC 660 | | AAGCTGTACC AGCAGATCAA GGCTGGGGCG TATGATTTCC CATCCCCTGA GTGGGACACC 720 | | GTTACTCCTG AAGCCAAAAA CCTCATCAAC CAGATGCTGA CCATCAACCC TGCCAAGCGC 780 | | ATCACGGCCC ATGAGGCCCT GAAGCACCCA TGGGTCTGCC AACGTTCCAC CGTGGCCTCT 840 | | ATGATGCACA GACAGGAGAC TGTGGAATGT CTGAAGAAGT TCAATGCAAG GAGGAAGCTC 900 | | AAGGGAGCCA TCCTCACCAC TATGCTGGCC ACACGGAATT TCTCAGCAGC CAAGAGTTTA 960 | | CTCAACAAGA AAGCAGATGG AGTCAAGGAA TCTTCCGACA GCACCAACAC AACCATAGAG 1020 | | GATGAAGATG CCAAAGCCCG GAAGCAGGAA ATCATCAAGA CCACAGAGCA GCTCATTGAG 1080 | | GCCGTCAACA ATGGGGACTT TGAGGCCTAT GCGAAAATCT GTGACCCAGG CCTGACCTCA 1140 | | TTTGAGCCTG AAGCTCTGGG CAACCTGGTC GAAGGGATGG ATTTCCACAG ATTCTACTTT 1200 | | GAGAACCTGC TGGCCAAGAA CAGCAAGCCG ATCCACACCA CCATCCTGAA CCCGCACGTG 1260 | | CACGTCATTG GCGAGGATGC GGCATGCATC GCCTACATCC GCCTCACACA GTACATCGAT 1320 | | GGCCAGGGCA GACCCCGTAC CAGCCAGTCC GAAGAGACCC GTGTGTGGCA CCGCCGCGAC 1380 | | GGCAAGTGGC AGAATGTACA TTTCCACTGC TCGGGCGCTC CAGTGGCCCC GCTGCAGTGA 1440 |
|
| Domain Profile | S: 1 yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni 60 | yql+e++gkgafsvvrrcvk++tg+eyaakiintkklsardhqklerearicrllkh+ni | Q: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73 | 9*********************************************************** |
| S: 61 vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv 120 | vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqile+vlh+hq+gvv | Q: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133 | ************************************************************ |
| S: 121 hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk 180 | hrdlkpenlllask+kgaavkladfglaievqgdqqawfgfagtpgylspevlrk++ygk | Q: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193 | ************************************************************ |
| S: 181 pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml 240 | pvd+wacgvilyillvgyppfwdedqh+lyqqikagaydfpspewdtvtpeak+lin+ml | Q: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253 | ************************************************************ |
| S: 241 tinpakritadealkhpwi 259 | tinpakrita+ealkhpw+ | Q: 254 TINPAKRITAHEALKHPWV 272 | ******************8 |
|
Domain Sequence
(FASTA) | | YQLYEDIGKG AFSVVRRCVK LCTGHEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHSNI 60 | | VRLHDSISEE GFHYLVFDLV TGGELFEDIV AREYYSEADA SHCIQQILEA VLHCHQMGVV 120 | | HRDLKPENLL LASKCKGAAV KLADFGLAIE VQGDQQAWFG FAGTPGYLSP EVLRKEAYGK 180 | | PVDIWACGVI LYILLVGYPP FWDEDQHKLY QQIKAGAYDF PSPEWDTVTP EAKNLINQML 240 | | TINPAKRITA HEALKHPWV 259 |
|
| Keyword | ATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Direct protein sequencing; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005954 | ; C:calcium- and calmodulin-dependent protein kinase complex | | GO:0005829 | ; C:cytosol | | GO:0005815 | ; C:microtubule organizing center | | GO:0033017 | ; C:sarcoplasmic reticulum membrane | | GO:0051233 | ; C:spindle midzone | | GO:0005524 | ; F:ATP binding | | GO:0004683 | ; F:calmodulin-dependent protein kinase activity | | GO:0060466 | ; P:activation of meiosis involved in egg activation | | GO:0006816 | ; P:calcium ion transport | | GO:0000082 | ; P:G1/S transition of mitotic cell cycle | | GO:0002030 | ; P:inhibitory G-protein coupled receptor phosphorylation | | GO:0050885 | ; P:neuromuscular process controlling balance | | GO:0018105 | ; P:peptidyl-serine phosphorylation | | GO:2001235 | ; P:positive regulation of apoptotic signaling pathway | | GO:0061003 | ; P:positive regulation of dendritic spine morphogenesis | | GO:0010976 | ; P:positive regulation of neuron projection development | | GO:0090129 | ; P:positive regulation of synapse maturation | | GO:0046777 | ; P:protein autophosphorylation | | GO:0048169 | ; P:regulation of long-term neuronal synaptic plasticity | | GO:0032222 | ; P:regulation of synaptic transmission, cholinergic | | GO:0046686 | ; P:response to cadmium ion |
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| Prints | |
| Created Date | 20-Feb-2013 |