| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00236 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| STE/STE7 | 335.2 | 7.1E-100 | 168 | 419 | 252 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000034920 |
| UniProt Accession | Q9WVS7; Q8CFM3; Q8K360; Q9D222; |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 5 |
| Protein Synonyms/Alias | MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5; |
| Gene Name | Map2k5 |
| Gene Synonyms/Alias | Map2k5; Mek5, Mkk5, Prkmk5; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Acts as a scaffold for the formation of a ternaryMAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. |
| Protein Length | 448 |
Protein Sequence
(FASTA) | | MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60 | | EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120 | | KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 180 | | YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240 | | TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC 300 | | DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360 | | KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 420 | | QFNDGNSTVV SMWVCRALEE RRSQQGPP 448 |
|
Nucleotide Sequence
(FASTA) | | ATGCTGTGGC TGGCCCTTGG CCCCTTCTGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 60 | | ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 120 | | TTCAGGGATG TTCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCGACGAC GACAGCGTTT 180 | | GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GCGATGAAGA GATGAAGGCA 240 | | ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 300 | | CCGCTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 360 | | AAGGTGAATA CACGGGCTGG GCCATCTCAA CACACCAGCC CTGTGGTCTC AGATTCGCTT 420 | | CCAAGCAATA GCTTGAAGAA GTCCTCAGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 480 | | ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 540 | | TACAAAGCAC ATCATGTCCC AAGTGGGAAA ATTTTAGCTG TAAAGGTTAT TCTGTTAGAC 600 | | ATTACACTGG AGCTTCAGAA GCAGATCATG TCTGAGCTGG AAATCCTTTA TAAGTGTGAC 660 | | TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTCGTAG AAAACAGGAT TTCAATTTGT 720 | | ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTT 780 | | GGAAGAATTG CAGTTGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 840 | | CACAGAGATG TGAAGCCCTC CAACATGCTT GTAAACACAG GCGGACAGGT CAAGCTGTGT 900 | | GACTTTGGCG TGAGCACACA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960 | | GCTTACATGG CACCAGAAAG AATTTCAGGA GAGCAGTATG GGATCCATTC TGACGTGTGG 1020 | | AGCTTAGGAA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 1080 | | AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 1140 | | CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG CCGTTTGTAC ATTTCATCAC TCAGTGCATG 1200 | | AGGAAGCAGC CCAAGGAGAG ACCGGCGCCT GAGGAGCTGA TGGGTCACCC ATTCATCGTG 1260 | | CAGTTCAATG ATGGAAACTC CACTGTGGTG TCCATGTGGG TGTGCCGAGC TCTAGAGGAG 1320 | | AGGCGGAGCC AGCAGGGACC CCCGTGA 1347 |
|
| Domain Profile | S: 3 kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk 62 | ++lG+Gngg+V+k++h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++ | Q: 168 YRDTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG 226 | 5679************************************************.******* |
| S: 63 fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl 122 | fyGaf+ e+++sic+e+mdg+sld v++k ipe+vlg+iavavvk+l+yl+ +l | Q: 227 FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-SL 277 | ************************.6876.......9********************.78 |
| S: 123 kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk 182 | ki+HRDvKPsN+Lvn+ G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++ | Q: 278 KILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH 336 | *****************************************************.****** |
| S: 183 sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv 236 | sdvWslG++++ela gr+py++ ++ +l+ll++iv+e++p+lp efse f++f+ | Q: 337 SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPLGEFSEPFVHFI 396 | ***********************9999********************************* |
| S: 237 skClkkdekeRpklkellkhafi 259 | ++C++k++keRp +el+ h+fi | Q: 397 TQCMRKQPKERPAPEELMGHPFI 419 | **********************7 |
|
Domain Sequence
(FASTA) | | YRDTLGHGNG GTVYKAHHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60 | | YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120 | | NMLVNTGGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180 | | ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPLGE FSEPFVHFIT QCMRKQPKER 240 | | PAPEELMGHP FI 252 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |