EKS-MUM-00441

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00441

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	356.0	3.6E-106	65	341	277

Status

Reviewed

Ensembl Protein

ENSMUSP00000108647

UniProt Accession

Q8CFA1; Q3U3K2; Q3U7F5; Q3UFX2; Q5U404; Q6YBR8; Q6YBR9; Q6YBS0; Q6YBS1; Q8C5M0; Q8CC82; Q8CEA0;

Protein Name

Interleukin-1 receptor-associated kinase-like 2

Protein Synonyms/Alias

IRAK-2; mu-IRAK-2;

Gene Name

Irak2

Gene Synonyms/Alias

Irak2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000060477	ENSMUSP00000086416	ENSMUST00000089022
ENSMUSG00000060477	ENSMUSP00000086417	ENSMUST00000089023
ENSMUSG00000060477	ENSMUSP00000108647	ENSMUST00000113024
ENSMUSG00000060477	ENSMUSP00000055073	ENSMUST00000059286
ENSMUSG00000060477	ENSMUSP00000117755	ENSMUST00000155554

Organism

Mus musculus

Functional Description

Binds to the IL-1 type I receptor following IL-1engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization (By similarity).

Protein Length

479

Protein Sequence
(FASTA)

MAGAQRQRPC EMDAPCSLKT DAPDSPQSKY CSTSTSAPKQ ERLLGLPGDR LFWSEADVVQ 60

ATEDFDQSHR ISEGTFADIY QGQRNGVAFA FKKLREVAGS SPGSMDRFLQ AEMQLCLRCC 120

HANVLPLLGF CTGRQFHSLI YPYMANGSLH DRLWAQGNSD MLPWPQRASI CSGLLLAVEH 180

LHSLDIIHSN VKSANVLLDQ HLNPKLAHPV AHPHPDNKKT KYTVMRTHLF QASAAYLPEH 240

FIRVGQLTKQ VDIFSCGIVL AEVLTGIPAM DKDRSPVYLK DLLLSEIPNS TSSVCSRKTS 300

MGKAVVKEIC QRHVEKRAGL LPEACEEAWA TAVSVCLRRR NASVEEARVS LAGVEEQLRG 360

QLSLPWSRVS EATGSSSNTP EETDDVDNSS LSVPSLVMMA SCPGAASSPL FTGHGAAQPS 420

TSGRQEADSS SEACTGPQTP QNATETSWKI EINEAKRRLM ENIVLYKEER LDSSELFGP 479

Nucleotide Sequence
(FASTA)

ATGGCTGGGG CCCAGCGGCA GCGTCCGTGC GAGATGGATG CCCCTTGTTC CCTGAAAACT 60

GATGCACCCG ACTCTCCCCA GTCTAAGTAT TGCAGTACTT CCACATCTGC CCCCAAGCAA 120

GAAAGGCTTT TGGGTTTGCC CGGAGACAGG CTTTTCTGGA GTGAAGCAGA TGTCGTCCAA 180

GCAACTGAGG ACTTTGACCA AAGCCACCGA ATCAGCGAGG GCACCTTTGC CGATATCTAC 240

CAGGGTCAAA GGAACGGTGT GGCCTTCGCC TTCAAGAAGC TCAGGGAGGT GGCCGGCTCC 300

AGTCCAGGGT CCATGGACAG ATTCCTACAG GCAGAGATGC AGCTCTGCCT CAGATGCTGC 360

CACGCGAACG TCCTACCTCT GCTGGGTTTC TGCACTGGAA GACAGTTCCA CAGCCTCATC 420

TACCCCTACA TGGCAAATGG CTCTCTGCAC GACAGACTCT GGGCTCAGGG CAACTCAGAC 480

ATGCTGCCCT GGCCACAGCG GGCCAGCATC TGCTCAGGGC TGCTTCTAGC CGTGGAGCAC 540

CTGCATAGCC TGGACATCAT CCACAGCAAT GTTAAGAGTG CCAACGTCTT GCTGGACCAG 600

CATCTTAACC CCAAGCTGGC TCATCCTGTG GCTCACCCTC ATCCCGACAA TAAAAAGACC 660

AAATATACCG TCATGAGGAC TCACCTGTTC CAGGCCTCAG CTGCATATCT GCCGGAACAC 720

TTCATCAGAG TGGGGCAGCT GACCAAGCAG GTGGACATCT TCAGCTGTGG AATTGTATTG 780

GCCGAGGTCC TTACCGGCAT CCCTGCGATG GACAAGGACC GCAGTCCAGT TTACCTGAAG 840

GATTTGCTTC TCAGTGAGAT TCCCAACAGT ACTTCTTCAG TCTGCTCCAG GAAGACCAGC 900

ATGGGGAAGG CAGTGGTGAA AGAGATCTGC CAGAGACATG TGGAGAAGAG GGCAGGGCTG 960

CTGCCTGAGG CCTGTGAGGA AGCCTGGGCC ACCGCTGTGA GTGTCTGCCT GCGGAGGCGC 1020

AATGCCAGCG TGGAGGAGGC ACGAGTCTCC CTGGCCGGGG TGGAGGAGCA ACTCCGAGGG 1080

CAGCTGTCCC TTCCCTGGAG CAGGGTTTCT GAGGCCACAG GCTCATCTTC CAATACCCCG 1140

GAGGAAACAG ATGACGTTGA CAATTCCAGC CTCAGCGTCC CTTCTTTGGT TATGATGGCA 1200

TCGTGCCCAG GGGCTGCCTC CTCTCCACTC TTCACGGGAC ATGGAGCAGC ACAGCCATCC 1260

ACCAGTGGGA GACAGGAGGC TGACTCCTCG TCAGAGGCTT GCACAGGCCC ACAGACACCC 1320

CAGAACGCTA CAGAGACTTC ATGGAAAATT GAGATCAATG AAGCCAAAAG GAGACTGATG 1380

GAGAACATCG TACTCTACAA AGAAGAGAGA CTGGACAGCA GCGAGCTCTT TGGACCCTGA 1440

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         f++++ri+eG+f+++y+g+++++a+a+kkl+e a +s+ ++++++++E+++++r++H+n+

Q: 65    FDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANV  124

         789*********************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120

         l+llg+++ +++++L+Y+ym+nGsL+drL++q++s++L+WpqR+si++G++ a+e+LH+

Q: 125   LPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNSDMLPWPQRASICSGLLLAVEHLHSL  184

         ************************************************************

S: 121   spslihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeef  180

           ++ih+++ksaN+LLD++l+pKl+ +++a+ +p+++k+++tv+rt+ +++++aYlpe+f

Q: 185   --DIIHSNVKSANVLLDQHLNPKLA-HPVAHPHPDNKKTKYTVMRTHLFQASAAYLPEHF  241

         ..***********************.**********************************

S: 181   irvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekv.........  231

         irvgqlt++vD++S+GiVl+EvltG++a+d+dr+++yLkdll +ei++++

Q: 242   IRVGQLTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSsvcsrktsm  301

         **************************************************99********

S: 232   ......eilekfldkkagkleeellealielalaclaeka  265

               ei++++++k+ag l+e+++ea++++ + cl +++

Q: 302   gkavvkEICQRHVEKRAGLLPEACEEAWATAVSVCLRRRN  341

         ************************************9775

Domain Sequence
(FASTA)

FDQSHRISEG TFADIYQGQR NGVAFAFKKL REVAGSSPGS MDRFLQAEMQ LCLRCCHANV 60

LPLLGFCTGR QFHSLIYPYM ANGSLHDRLW AQGNSDMLPW PQRASICSGL LLAVEHLHSL 120

DIIHSNVKSA NVLLDQHLNP KLAHPVAHPH PDNKKTKYTV MRTHLFQASA AYLPEHFIRV 180

GQLTKQVDIF SCGIVLAEVL TGIPAMDKDR SPVYLKDLLL SEIPNSTSSV CSRKTSMGKA 240

VVKEICQRHV EKRAGLLPEA CEEAWATAVS VCLRRRN 277

Keyword

Alternative splicing; ATP-binding; Complete proteome; Nucleotide-binding; Phosphoprotein; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005829	; C:cytosol
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0032088	; P:negative regulation of NF-kappaB transcription factor activity
GO:0043433	; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0001959	; P:regulation of cytokine-mediated signaling pathway

KEGG

mmu:108960

;

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50017	; DEATH_DOMAIN; FALSE_NEG.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013