EPS-MUM-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	288.8	1.2E-85	23	293	271

Status

Reviewed

Ensembl Protein

ENSMUSP00000107924

UniProt Accession

P36993;

Protein Name

Protein phosphatase 1B

Protein Synonyms/Alias

Protein phosphatase 2C isoform beta; PP2C-beta;

Gene Name

Ppm1b

Gene Synonyms/Alias

Ppm1b; Pp2c2, Pppm1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000061130	ENSMUSP00000107924	ENSMUST00000112305
ENSMUSG00000061130	ENSMUSP00000079107	ENSMUST00000080217
ENSMUSG00000061130	ENSMUSP00000107926	ENSMUST00000112307
ENSMUSG00000061130	ENSMUSP00000107923	ENSMUST00000112304

Organism

Mus musculus

Functional Description

Enzyme with a broad specificity.

Protein Length

390

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL DNWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT TNEDFRAADK SGSALEPSVE SVKTGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMVS PTHMYFINCG DSRAVLCRNG QVCFSTQDHK PCNPVEKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIV RAEEDEFVVL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSV VLVCFSNAPK 300

VSEEAVKRDS ELDKHLESRV EEIMQKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

HVIEAVYSRL NPHKDNDGMA DLSTSICKPS 390

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAAAAGCACA ATGCTCACGG TGCTGGGAAT 60

GGTCTGCGTT ATGGCCTGAG CAGTATGCAA GGATGGAGAG TAGAAATGGA AGATGCACAC 120

ACAGCTGTTG TGGGTATTCC TCACGGCTTG GACAACTGGT CGTTTTTTGC AGTTTATGAC 180

GGTCATGCTG GATCCCGAGT GGCAAATTAC TGTTCAACAC ATCTATTAGA ACACATCACC 240

ACCAATGAAG ACTTCAGGGC AGCTGACAAA TCAGGCTCTG CTCTCGAGCC TTCAGTAGAA 300

AGTGTGAAGA CTGGTATCAG GACTGGCTTT TTGAAAATTG ATGAATATAT GCGTAACTTC 360

TCAGACCTGA GGAACGGGAT GGACAGGAGC GGCTCGACTG CAGTGGGCGT GATGGTCTCC 420

CCTACACACA TGTACTTCAT CAACTGTGGT GACTCTCGAG CTGTTCTGTG TAGGAACGGA 480

CAGGTCTGCT TTTCTACCCA GGATCACAAA CCTTGTAATC CAGTGGAGAA GGAGCGCATC 540

CAAAACGCAG GAGGCAGTGT GATGATCCAG CGTGTGAACG GCTCACTAGC AGTGTCTCGG 600

GCTCTGGGGG ACTATGACTA CAAGTGTGTG GATGGCAAGG GCCCTACAGA GCAGCTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAGATTGTG AGAGCAGAAG AGGATGAGTT TGTCGTCTTG 720

GCCTGTGATG GGATCTGGGA TGTGATGAGC AATGAGGAGC TCTGTGAGTT TGTTAAGTCT 780

AGGCTTGAGG TGTCGGACGA CCTGGAGAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTGTT GTATTAGTTT GCTTTTCAAA TGCCCCCAAG 900

GTCTCAGAGG AAGCCGTGAA GAGAGATTCA GAGTTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAAATCA TGCAGAAGTC TGGGGAGGAA GGAATGCCTG ATCTTGCCCA TGTGATGCGC 1020

ATTTTGTCTG CAGAAAATAT CCCGAATTTA CCTCCCGGGG GAGGTCTCGC TGGCAAGCGC 1080

CATGTTATTG AAGCTGTTTA TAGTAGACTT AATCCACACA AAGACAATGA TGGGATGGCA 1140

GACTTGAGCA CGTCTATTTG TAAACCCAGC TGA 1173

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++       d+++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPHG---LDNWSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************985555544...455***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ + vk+ ++++Fl++de ++++++ ++ +d+sGstav +++

Q: 80    TTNEDfraadksgsALEPSVESVKTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMV  139

         ***99********9999*******************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravLcrng+++  ++dHkp ++ E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCNPVEKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef++La+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSVVLV  293

         ********************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLDN WSFFAVYDGH AGSRVANYCS THLLEHITTN 60

EDFRAADKSG SALEPSVESV KTGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMVSPT 120

HMYFINCGDS RAVLCRNGQV CFSTQDHKPC NPVEKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEIVRA EEDEFVVLAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSVVL V 271

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

mmu:19043

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013