EKS-MUM-00365
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00365
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20315.56.7E-9426277252
StatusReviewed
Ensembl ProteinENSMUSP00000116920
UniProt AccessionQ8BYC6; Q3V3B3;
Protein NameSerine/threonine-protein kinase TAO3
Protein Synonyms/Alias Thousand and one amino acid protein 3;
Gene NameTaok3
Gene Synonyms/Alias Taok3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000061288ENSMUSP00000116920ENSMUST00000145640
ENSMUSG00000061288ENSMUSP00000119998ENSMUST00000127814
ENSMUSG00000061288ENSMUSP00000136750ENSMUST00000179276
ENSMUSG00000061288ENSMUSP00000090565ENSMUST00000092889
ENSMUSG00000061288ENSMUSP00000107606ENSMUST00000111975
ENSMUSG00000061288ENSMUSP00000117841ENSMUST00000125738
ENSMUSG00000061288ENSMUSP00000107609ENSMUST00000111978
OrganismMus musculus
Functional DescriptionSerine/threonine-protein kinase that acts as a regulatorof the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity).
Protein Length561
Protein Sequence
(FASTA)
MRKGALKDPE IADLFFKDDP EELFIDLHEI GHGSFGAVYF ATNAHTNEVV AVKKMSYSGK 60
QTHEKWQDIL KEVKFLQQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ 120
EVEIAAITHG ALQGLAYLHF HSLIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG 180
TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT 240
LQSREWTDSF RRFVDYCLHK IPQERPAAVE LLRHDFIRRE RPPKVLIDLI QRTKDAVREL 300
DNLQYRKMKK ILFQETRNGP LNESQEEEED GEQGSNLNRE VDSLGSIHSI PSTSVSTGSR 360
SSSVNSMQEV MDESSSELVM MQEDEGTANS SASTVHKKDH VFVRDEAGHG DPRPEPRPTQ 420
SVQSRALHYR NRERFATIKS ASLVTRQIHE HEQENELREQ MSGYKRMRRQ HQKQLIALEN 480
KLKAEMDEHR LKLQKEVETH ANNSSIELEK LAKKQVATIE KEAKVAAADE KKFQQQILAQ 540
QKKDLTTFLE SQKKQYKICK E 561
Nucleotide Sequence
(FASTA)
ATGCGTAAAG GGGCACTGAA GGACCCAGAG ATTGCTGATC TGTTCTTCAA GGATGACCCC 60
GAAGAGCTTT TTATCGATTT GCATGAAATT GGACATGGGA GCTTTGGAGC CGTGTACTTT 120
GCGACAAATG CGCACACCAA CGAGGTGGTC GCTGTTAAGA AAATGTCCTA CAGTGGGAAG 180
CAGACCCATG AGAAATGGCA AGATATCCTT AAGGAAGTTA AGTTTCTGCA GCAGCTGAAG 240
CATCCTAACA CCATCGAGTA CAAAGGCTGT TATTTAAAGG AGCACACTGC ATGGTTGGTG 300
ATGGAGTACT GCCTAGGTTC AGCCTCTGAC TTGTTAGAAG TTCATAAGAA ACCACTTCAG 360
GAAGTGGAGA TCGCTGCTAT CACCCATGGT GCCTTGCAGG GGCTGGCCTA CCTCCACTTT 420
CACTCCCTGA TTCACAGGGA CATTAAAGCA GGGAACATCC TCCTCACAGA GCCAGGTCAG 480
GTGAAGCTGG CTGACTTCGG ATCTGCCTCC ATGGCTTCTC CCGCCAACTC CTTTGTGGGG 540
ACTCCTTACT GGATGGCCCC AGAGGTAATC TTAGCTATGG ACGAAGGGCA GTACGACGGG 600
AAAGTTGACA TCTGGTCGCT TGGCATCACC TGCATAGAGT TGGCGGAGCG GAAGCCCCCC 660
CTCTTCAACA TGAACGCCAT GAGCGCCCTC TACCACATCG CTCAGAATGA CTCCCCCACG 720
CTACAGTCCA GGGAATGGAC AGACTCCTTC AGGAGATTCG TTGATTACTG CTTGCACAAA 780
ATACCTCAGG AAAGACCAGC CGCGGTGGAG CTGTTGCGGC ATGACTTCAT TCGGAGGGAG 840
CGGCCACCGA AGGTCCTCAT TGATCTCATA CAGAGGACAA AAGATGCTGT CCGAGAGCTG 900
GACAACCTGC AGTACAGGAA AATGAAGAAG ATCCTCTTCC AGGAGACTCG GAACGGACCC 960
TTGAATGAGT CGCAAGAAGA AGAAGAAGAT GGTGAGCAAG GAAGCAACCT GAACCGAGAG 1020
GTGGACAGTC TGGGCAGCAT CCACTCCATT CCCAGCACAT CAGTGAGCAC AGGCAGCCGG 1080
AGCAGCAGTG TGAACAGCAT GCAGGAGGTC ATGGATGAGA GCAGCTCTGA GCTCGTCATG 1140
ATGCAGGAGG ATGAAGGCAC AGCCAACTCC AGCGCCTCCA CGGTACACAA GAAGGATCAT 1200
GTATTCGTAA GGGATGAGGC GGGCCACGGC GATCCCAGGC CTGAGCCGCG GCCTACCCAG 1260
TCAGTTCAGA GCCGGGCCCT CCACTATCGG AACCGAGAGC GCTTTGCCAC GATCAAATCC 1320
GCGTCTTTGG TTACACGGCA GATCCATGAG CATGAGCAGG AGAACGAGCT GCGGGAACAG 1380
ATGTCAGGTT ATAAGCGGAT GCGGCGCCAG CACCAGAAGC AGCTGATCGC CCTGGAGAAC 1440
AAGCTGAAGG CTGAGATGGA TGAGCACCGC CTCAAGCTCC AGAAGGAGGT GGAGACGCAC 1500
GCCAACAACT CGTCCATCGA GCTGGAGAAG CTGGCCAAGA AGCAAGTGGC TACCATAGAA 1560
AAGGAGGCAA AGGTAGCCGC AGCGGATGAG AAGAAGTTCC AGCAGCAGAT CCTGGCCCAG 1620
CAGAAGAAGG ACTTGACAAC TTTCTTAGAA AGTCAGAAGA AGCAGTACAA GATTTGTAAG 1680
GAG 1683
Domain Profile
S: 3     lleeigkGalgkvylarekktgelvaikkinlekq...ekleelqkeisvlkklkhpniv  59
          l+eig+G++g+vy a++ +t+e+va+kk++++ +   ek++++ ke+++l++lkhpn +
Q: 26    DLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKqthEKWQDILKEVKFLQQLKHPNTI  85
         5789****************************988899**********************
S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119
         ey +++lke++ wlvmey+  Gs+sdl++ ++k++l+E +ia+i++++l++L+ylH +  
Q: 86    EYKGCYLKEHTAWLVMEYCL-GSASDLLE-VHKKPLQEVEIAAITHGALQGLAYLHFHSL  143
         *******************7.********.******************************
S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYd  178
         iHrdika+niLlte g+VkL+dfg+a+  +      +++vgtpywmAPEvi ++ e +Yd
Q: 144   IHRDIKAGNILLTEPGQVKLADFGSASMASP----ANSFVGTPYWMAPEVILAMdEGQYD  199
         ************************9998888....69**************9887999**
S: 179   ekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekcl  238
          k+DiwslGIt+ielae++pP++++++++al++i++n++p+l+s+ +++++f++fv+ cl
Q: 200   GKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSR-EWTDSFRRFVDYCL  258
         ******************************************777.**************
S: 239   qknpekRpsasellkhkFl  257
         +k p++Rp+a ell+h F+
Q: 259   HKIPQERPAAVELLRHDFI  277
         ******************7
Domain Sequence
(FASTA)
DLHEIGHGSF GAVYFATNAH TNEVVAVKKM SYSGKQTHEK WQDILKEVKF LQQLKHPNTI 60
EYKGCYLKEH TAWLVMEYCL GSASDLLEVH KKPLQEVEIA AITHGALQGL AYLHFHSLIH 120
RDIKAGNILL TEPGQVKLAD FGSASMASPA NSFVGTPYWM APEVILAMDE GQYDGKVDIW 180
SLGITCIELA ERKPPLFNMN AMSALYHIAQ NDSPTLQSRE WTDSFRRFVD YCLHKIPQER 240
PAAVELLRHD FI 252
KeywordATP-binding; Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA repair; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Gadus morhua"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>
EKS-AIM-00304
EKS-GAM-00202
EKS-ORL-00398
EKS-PAT-00314
Gene Ontology
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006281; P:DNA repair
GO:0031572; P:G2/M transition DNA damage checkpoint
GO:0000165; P:MAPK cascade
GO:0046329; P:negative regulation of JNK cascade
GO:0046330; P:positive regulation of JNK cascade
GO:0043507; P:positive regulation of JUN kinase activity
GO:0032874; P:positive regulation of stress-activated MAPK cascade
GO:0046777; P:protein autophosphorylation
KEGG
mmu:330177;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013