EKS-MUM-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trio	401.6	3.5E-120	987	1241	255

Status

Reviewed

Ensembl Protein

ENSMUSP00000110624

UniProt Accession

A2CG49; A2CG50; A2CG51; A2CG52; A2CG53; B2RXR5; Q3TXY8; Q3TYL1; Q3UTA5; Q8BTT9; Q8C4Q2; Q9CVA9;

Protein Name

Kalirin

Protein Synonyms/Alias

Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain;

Gene Name

Kalrn

Gene Synonyms/Alias

Kalrn;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000061751	ENSMUSP00000116188	ENSMUST00000142817
ENSMUSG00000061751	ENSMUSP00000076088	ENSMUST00000076810
ENSMUSG00000061751	ENSMUSP00000087084	ENSMUST00000089655
ENSMUSG00000061751	ENSMUSP00000110611	ENSMUST00000114960
ENSMUSG00000061751	ENSMUSP00000123416	ENSMUST00000151491
ENSMUSG00000061751	ENSMUSP00000110597	ENSMUST00000114947
ENSMUSG00000061751	ENSMUSP00000110617	ENSMUST00000114966
ENSMUSG00000061751	ENSMUSP00000110604	ENSMUST00000114954
ENSMUSG00000061751	ENSMUSP00000110603	ENSMUST00000114953
ENSMUSG00000061751	ENSMUSP00000110599	ENSMUST00000114949
ENSMUSG00000061751	ENSMUSP00000110612	ENSMUST00000114961
ENSMUSG00000061751	ENSMUSP00000110624	ENSMUST00000114973
ENSMUSG00000061751	ENSMUSP00000110615	ENSMUST00000114964
ENSMUSG00000061751	ENSMUSP00000110614	ENSMUST00000114963

Organism

Mus musculus

Functional Description

Promotes the exchange of GDP by GTP. Activates specificRho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).

Protein Length

1295

Protein Sequence
(FASTA)

MKGGDQAYTR GPSLGWLFAK CCCCFPCRDS YSHSSSENGG KSESVAHLQS QPSLNSIHSS 60

PGPKRSTNTL KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS 120

ADEKSKKGWG EDEPDEESHT PLPPPMKIFD NDPTQDEMSS LLAARQAPPD VPTAADLVSA 180

IEKLVKNKLT LEGGSYRGSL KDPTGCLNEG MTPPTPPRNL EEEQKAKALR GRMFVLNELV 240

QTEKDYVKDL GIVVEGFMKR IEEKGVPEDM RGKEKIVFGN IHQIYDWHKD FFLAELEKCI 300

QEQDRLAQLF IKHERKLHIY VWYCQNKPRS EYIVAEYDAY FEEVKQEINQ RLTLSDFLIK 360

PIQRITKYQL LLKDFLRYSE KAGLECSDIE KAVELMCLVP KRCNDMMNLG RLQGFEGTLT 420

AQGKLLQQDT FYVIELDAGM QSRTKERRVF LFEQIVIFSE LLRKGSLTPG YMFKRSIKMN 480

YLVLEDNVDG DPCKFALMNR ETSERVILQA ANSDIQQAWV QDINQVLETQ RDFLNALQSP 540

IEYQRKERST AVIRSQPPRV PQASPRPYSS GPVGSEKPPK GSSYNPPLPP LKISTSNGSP 600

GFDYHQPGDK FDASKQNDLG GCNGTSTMTV IKDYYALKEN EICVSQGEVV QVLAVNQQNM 660

CLVYQPASDH SPAAEGWVPG SILAPLAKAT AAAESSDGSI KKSCSWHTLR MRKRADVENS 720

GKNEATGPRK PKDILGNKVS VKETNSSEES ECDDLDPNTS MEILNPNFIQ EVAPEFLVPL 780

VDVTCLLGDT VLLQCKACGR PKPSITWKGP DQNILDTDNS SATYTISSCD SGESTLKICN 840

LMPQDSGIYT CIAANDHGTA STSATVKVQG VPAAPNRPIA QERSCTSVIL RWLPPASTGN 900

CTISGYTVEY REEGSQVWQQ SVASTLDTYL VIEDLSPGCP YQFRVSASNP WGISLPSEPS 960

EFVRLPEYDA AADGATISWK ENFDSAYTEL NEIGRGRFSI VKKCIHKATR KDVAVKFVSK 1020

KMKKKEQAAH EAALLQHLQH PQYVTLHDTY ESPTSYILIL ELMDDGRLLD YLMNHDELME 1080

EKVAFYIRDI MEALQYLHNC RVAHLDIKPE NLLIDLRIPV PRVKLIDLED AVQISGHFHI 1140

HHLLGNPEFA APEVIQGIPV SLGTDIWSIG VLTYVMLSGV SPFLDESKEE TCINVCRVDF 1200

SFPHEYFCGV SNAARDFINV ILQEDFRRRP TAATCLQHPW LQPHNGSYSK IPLDTSRLAC 1260

FIERRKHQND VRPIPNVKSY IVNRVNQGTS LSHNP 1295

Nucleotide Sequence
(FASTA)

ATGAAGGGTG GCGATCAGGC TTACACCCGA GGTCCCTCTT TGGGCTGGCT CTTTGCTAAG 60

TGCTGCTGTT GCTTCCCTTG TAGAGATTCA TACTCTCATT CCTCCAGTGA GAATGGAGGC 120

AAATCCGAGT CCGTGGCCCA CCTGCAGTCT CAGCCCTCCC TGAACTCCAT CCACAGTTCC 180

CCTGGTCCCA AGCGCTCCAC CAACACCCTC AAAAAGTGGC TGACCAGCCC CGTGCGCCGC 240

CTCAACAGCG GAAAAGCCGA CGGGAACATC AAAAAGCAGA AGAAAGTCCG GGATGGGCGG 300

AAGAGCTTCG ATCTGGGATC GCCCAAGCCT GGGGATGAGA CGACACCTCA GGGAGACAGC 360

GCTGACGAGA AGAGCAAGAA GGGTTGGGGC GAAGACGAGC CAGATGAAGA GTCACACACA 420

CCCCTCCCTC CGCCCATGAA GATCTTTGAC AACGACCCCA CACAGGATGA GATGTCGTCT 480

TTGCTAGCAG CCCGGCAGGC TCCCCCTGAC GTGCCTACTG CTGCAGACCT TGTCAGTGCA 540

ATAGAAAAGT TGGTCAAAAA TAAGCTGACT CTGGAAGGAG GCTCTTACCG GGGGAGCTTG 600

AAGGACCCTA CAGGCTGCCT GAATGAGGGG ATGACCCCTC CCACACCTCC TAGAAACCTG 660

GAAGAAGAAC AGAAAGCCAA GGCGCTGAGA GGCAGGATGT TTGTCCTGAA TGAGCTGGTA 720

CAGACAGAGA AGGACTACGT CAAGGACCTG GGGATTGTGG TGGAGGGCTT CATGAAGAGA 780

ATAGAAGAGA AGGGGGTCCC TGAGGACATG CGAGGGAAGG AAAAGATCGT GTTTGGAAAT 840

ATCCACCAGA TTTACGACTG GCATAAAGAT TTTTTCCTGG CTGAACTGGA AAAATGTATC 900

CAAGAGCAAG ACAGATTGGC CCAGCTCTTC ATTAAACACG AGCGGAAGCT GCACATCTAC 960

GTGTGGTACT GCCAGAACAA GCCGCGTTCC GAGTACATCG TGGCTGAGTA CGATGCCTAT 1020

TTTGAGGAGG TTAAACAAGA GATCAATCAA AGGCTGACCC TTAGTGACTT CCTGATCAAG 1080

CCCATTCAGA GAATAACAAA GTACCAGCTG CTACTCAAGG ACTTCCTGCG ATACAGCGAG 1140

AAGGCTGGTT TGGAGTGTTC CGATATTGAG AAAGCAGTGG AGTTAATGTG CCTTGTCCCC 1200

AAGCGCTGTA ATGACATGAT GAATCTGGGA CGCCTGCAGG GCTTCGAGGG CACCCTGACC 1260

GCCCAGGGCA AGCTACTGCA GCAGGACACA TTCTATGTGA TCGAGCTGGA TGCCGGCATG 1320

CAGTCCCGGA CCAAGGAGAG GCGTGTGTTT CTCTTTGAGC AGATTGTCAT CTTCAGTGAA 1380

CTGCTCCGAA AGGGGTCCCT CACCCCAGGC TACATGTTCA AAAGAAGCAT CAAGATGAAT 1440

TACTTGGTCC TGGAAGACAA TGTGGATGGT GACCCCTGCA AATTTGCACT CATGAACAGG 1500

GAGACTTCAG AAAGGGTCAT TCTACAGGCT GCCAACTCAG ACATCCAGCA GGCCTGGGTG 1560

CAGGACATCA ACCAAGTCCT AGAAACACAG AGGGACTTCT TAAATGCACT ACAGTCACCC 1620

ATTGAGTATC AGCGGAAGGA GAGAAGCACA GCTGTGATCC GGTCCCAGCC CCCGAGGGTT 1680

CCACAAGCCA GCCCCAGGCC CTACTCTTCT GGCCCGGTGG GCTCAGAGAA GCCCCCCAAG 1740

GGCTCCAGCT ATAACCCGCC TCTGCCACCC CTGAAGATAT CTACCTCTAA TGGCAGTCCA 1800

GGGTTCGACT ACCATCAGCC TGGGGACAAG TTTGACGCTA GCAAGCAGAA CGACCTGGGA 1860

GGCTGCAATG GGACATCAAC CATGACTGTA ATCAAAGATT ACTATGCACT GAAGGAGAAT 1920

GAAATCTGCG TGAGCCAAGG TGAGGTGGTA CAGGTCCTCG CCGTCAACCA GCAGAACATG 1980

TGTCTGGTGT ACCAGCCTGC CAGCGACCAT TCCCCGGCAG CAGAGGGCTG GGTCCCAGGC 2040

AGCATCCTGG CGCCCCTCGC CAAAGCCACA GCAGCGGCCG AAAGTAGTGA CGGGAGCATC 2100

AAGAAGTCAT GCTCTTGGCA CACTCTACGC ATGAGAAAGC GGGCAGACGT GGAGAACTCG 2160

GGTAAAAATG AAGCCACAGG GCCTCGTAAA CCCAAGGATA TTCTGGGCAA CAAAGTCTCT 2220

GTTAAAGAGA CGAACAGTTC CGAGGAGTCA GAGTGTGATG ATCTTGACCC TAATACTAGT 2280

ATGGAGATCT TGAATCCAAA TTTCATCCAG GAAGTGGCTC CAGAATTCCT CGTGCCCTTA 2340

GTAGATGTGA CCTGTTTGCT TGGAGACACA GTGCTACTGC AGTGTAAAGC CTGTGGGCGG 2400

CCAAAGCCCA GCATCACCTG GAAGGGTCCG GATCAGAACA TCCTAGACAC TGACAACAGT 2460

TCAGCAACAT ACACCATCTC CTCCTGTGAT TCTGGGGAAA GCACCCTCAA GATCTGCAAC 2520

CTGATGCCCC AGGATAGTGG GATTTATACC TGCATAGCAG CAAACGACCA CGGGACTGCA 2580

TCCACATCTG CTACAGTTAA GGTGCAAGGT GTCCCCGCAG CCCCCAACCG CCCAATCGCA 2640

CAGGAGAGGA GCTGCACCTC CGTCATCCTC CGCTGGCTGC CCCCAGCCAG CACCGGAAAC 2700

TGCACTATTT CGGGGTACAC AGTGGAGTAT CGCGAGGAAG GTTCCCAGGT CTGGCAGCAA 2760

TCCGTAGCTT CGACCTTGGA CACTTACCTG GTCATTGAAG ACCTTAGTCC TGGGTGCCCT 2820

TATCAGTTCA GGGTCAGTGC CAGCAACCCC TGGGGAATCA GCCTTCCCAG TGAGCCCTCG 2880

GAGTTTGTGC GCCTTCCAGA GTACGATGCA GCCGCCGACG GTGCCACCAT TTCTTGGAAG 2940

GAAAATTTTG ATTCTGCTTA CACTGAACTG AACGAGATTG GCAGAGGCCG TTTCTCTATT 3000

GTAAAGAAAT GCATTCACAA AGCTACCCGC AAAGATGTTG CTGTGAAATT TGTGAGCAAA 3060

AAAATGAAGA AGAAGGAGCA GGCTGCTCAC GAGGCCGCCC TGCTCCAGCA CCTGCAGCAC 3120

CCTCAGTATG TCACGCTCCA TGACACCTAC GAGTCCCCCA CATCCTACAT CCTGATTTTG 3180

GAACTGATGG ATGACGGCCG ACTCTTGGAC TACCTTATGA ATCATGATGA GCTGATGGAA 3240

GAAAAGGTAG CTTTCTACAT TCGAGACATC ATGGAAGCTC TGCAGTACCT GCACAACTGT 3300

AGGGTCGCAC ATTTGGACAT AAAGCCCGAA AACCTGCTCA TTGACCTCCG GATCCCAGTG 3360

CCTCGAGTGA AGCTCATCGA CTTGGAAGAC GCTGTCCAGA TCTCAGGCCA CTTCCATATC 3420

CACCATCTGC TGGGGAACCC TGAGTTCGCT GCCCCCGAAG TGATCCAAGG CATCCCTGTC 3480

TCCCTGGGCA CAGACATCTG GAGCATCGGG GTTCTGACAT ATGTCATGCT TAGTGGGGTC 3540

TCCCCCTTCT TAGATGAGAG CAAAGAGGAA ACCTGTATCA ACGTGTGCAG GGTGGACTTT 3600

AGCTTCCCCC ACGAGTACTT CTGCGGTGTG AGCAATGCTG CCAGGGATTT CATCAACGTA 3660

ATCTTACAGG AAGACTTCCG GAGGCGGCCC ACAGCAGCCA CGTGCCTGCA GCATCCCTGG 3720

CTACAGCCCC ACAACGGCAG CTACTCCAAG ATCCCCTTGG ACACCTCCCG TCTGGCCTGC 3780

TTCATAGAAC GCCGCAAGCA CCAGAATGAT GTGCGGCCCA TTCCCAATGT CAAGAGTTAC 3840

ATCGTCAATA GGGTGAACCA AGGGACCTCG CTATCCCACA ACCCCTGA 3888

Domain Profile

S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60

         y++l+eigRGrFs+vkk+++kat+++va+kfv+kk+kkk+q+++Ea++L++LqHp++v+l

Q: 987   YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYVTL  1046

         899*********************************************************

S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120

         hd+ye+p+s++lilEl++d++LLd+l+++++l+E++v++y+r+++ealqYLHn+rv+HLD

Q: 1047  HDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLD  1106

         ************************************************************

S: 121   ikpenllv.laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatDi  179

         ikpenll+ l+++ ++vk++Dl++A++++ ++++++llg+pEf+aPE+i+g pvs +tDi

Q: 1107  IKPENLLIdLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDI  1166

         ********99**************************************************

S: 180   WavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqedp  239

         W++Gvl+yv+LsgvsPfldesk+et++n++++++sf++e+f+g+s++A++F++++Lqed+

Q: 1167  WSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDF  1226

         ************************************************************

S: 240   rkRPsaaecLqhpWl  254

         r+RP+aa+cLqhpWl

Q: 1227  RRRPTAATCLQHPWL  1241

         **************8

Domain Sequence
(FASTA)

YTELNEIGRG RFSIVKKCIH KATRKDVAVK FVSKKMKKKE QAAHEAALLQ HLQHPQYVTL 60

HDTYESPTSY ILILELMDDG RLLDYLMNHD ELMEEKVAFY IRDIMEALQY LHNCRVAHLD 120

IKPENLLIDL RIPVPRVKLI DLEDAVQISG HFHIHHLLGN PEFAAPEVIQ GIPVSLGTDI 180

WSIGVLTYVM LSGVSPFLDE SKEETCINVC RVDFSFPHEY FCGVSNAARD FINVILQEDF 240

RRRPTAATCL QHPWL 255

Keyword

3D-structure; Alternative initiation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disulfide bond; Guanine-nucleotide releasing factor; Immunoglobulin domain; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Felis catus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Oryctolagus cuniculus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0043005	; C:neuron projection
GO:0043025	; C:neuronal cell body
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005089	; F:Rho guanyl-nucleotide exchange factor activity
GO:0007409	; P:axonogenesis
GO:0035556	; P:intracellular signal transduction
GO:0050773	; P:regulation of dendrite development
GO:0035023	; P:regulation of Rho protein signal transduction

KEGG

mmu:545156

;

InterPros

IPR001251	; CRAL-TRIO_dom.
IPR000219	; DH-domain.
IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001452	; SH3_domain.
IPR018159	; Spectrin/alpha-actinin.
IPR002017	; Spectrin_repeat.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF00069	; Pkinase; 1.
PF00621	; RhoGEF; 2.
PF00018	; SH3_1; 1.
PF00435	; Spectrin; 4.

SMARTs

SM00060	; FN3; 1.
SM00408	; IGc2; 1.
SM00233	; PH; 2.
SM00325	; RhoGEF; 2.
SM00220	; S_TKc; 1.
SM00516	; SEC14; 1.
SM00326	; SH3; 2.
SM00150	; SPEC; 7.

Prosites

PS50191	; CRAL_TRIO; 1.
PS50010	; DH_2; 2.
PS50853	; FN3; 1.
PS50835	; IG_LIKE; 1.
PS50003	; PH_DOMAIN; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013