EPS-MUM-00127

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00127

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	544.6	1.5E-163	124	455	332

Status

Reviewed

Ensembl Protein

ENSMUSP00000071191

UniProt Accession

O35655; A2AIC6;

Protein Name

Serine/threonine-protein phosphatase with EF-hands 1

Protein Synonyms/Alias

PPEF-1; DRES10; Protein phosphatase with EF calcium-binding domain; PPEF;

Gene Name

Ppef1

Gene Synonyms/Alias

Ppef1; Dres10, Ppef;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000062168	ENSMUSP00000123408	ENSMUST00000135856
ENSMUSG00000062168	ENSMUSP00000121692	ENSMUST00000136888
ENSMUSG00000062168	ENSMUSP00000071191	ENSMUST00000071204

Organism

Mus musculus

Functional Description

May have a role in the recovery or adaptation responseof photoreceptors. May have a role in diverse sensory neurons and in development.

Protein Length

650

Protein Sequence
(FASTA)

MGCGTSSKKG NKSKKVIKAA LVIQNWYRRY RARLRVRQHY ALAIFQSIEY SDEQGQMQLS 60

SFFSFMLENY TKTNNEDSAL VTRIFDNTRR ESQIKDRDDF LGLIEVPDSY DGPRLQFPLT 120

FTDIHILLQA FKQQQILHAH YVLEVLFEAR KVLKQMPNFS HVKTFPAKEI TICGDLHGKL 180

DDLMLIFYKN GLPSENNPYV FNGDFVDRGN NSMEILMILL VCFLVYPSDL HLNRGNHEDF 240

MMNLRYGFTK EILQKYKLHG RKILQVLEEV YTWLPIGTII DNEILVIHGG ISESTDLNTL 300

HQLQRNKMKS VLMPPVLGNQ ETGEKRNKSA SNYVEPRKVE PDKTPSEDLT KQEWEQIVDI 360

LWSDPRGKKG CYPNTSRGGG CYFGPDVTSK VLSKNQLKML IRSHECKPDG YEVSHDGKVI 420

TVFSASNYYE EGSNRGAYIR LSYGTMPQFF QYQVTSTSCL NPLHQRMNAM ESSAFKILKE 480

KMISRKTDLI NAFELRDHSR SGRISLAEWA FSMENILGLN LPWRSLSSHL VTIDSSGSVD 540

YMSSFDDIRI EKPTKDMKSN LTETMYRYRS DLKIIFNIID SDQSGLISMD EFRTMWKLFN 600

AHYKAHIDDS QIDELASIVD FNKDGNIDFN EFLKAFYVVH KYDKPGTSLA 650

Nucleotide Sequence
(FASTA)

ATGGGCTGTG GCACTTCTTC AAAAAAAGGC AACAAATCTA AGAAAGTGAT AAAAGCCGCG 60

TTAGTCATCC AAAATTGGTA CCGGCGGTAC AGAGCTCGAC TGAGGGTCAG ACAGCATTAT 120

GCCCTCGCCA TCTTCCAGTC TATTGAATAT TCTGACGAGC AAGGCCAAAT GCAGCTATCC 180

AGCTTCTTTT CGTTCATGTT GGAAAACTAC ACAAAGACAA ATAATGAAGA TTCAGCATTA 240

GTAACTCGAA TTTTTGACAA CACCAGGCGG GAAAGCCAAA TCAAGGATAG AGATGACTTT 300

TTGGGGTTGA TAGAAGTGCC TGACTCCTAT GATGGTCCTC GGCTGCAGTT TCCTCTGACG 360

TTTACTGACA TCCATATACT TCTTCAGGCC TTCAAGCAAC AGCAGATACT TCATGCTCAC 420

TACGTCTTAG AGGTGCTATT TGAAGCTAGG AAAGTCCTGA AGCAAATGCC GAATTTCTCT 480

CATGTAAAAA CCTTTCCCGC CAAAGAGATA ACAATATGTG GTGATTTGCA TGGGAAACTG 540

GATGATCTTA TGCTGATTTT CTATAAGAAT GGCCTGCCTT CAGAGAACAA TCCATACGTT 600

TTCAATGGTG ACTTTGTAGA TCGAGGAAAC AATTCCATGG AGATCCTAAT GATCCTGCTT 660

GTTTGTTTTC TTGTCTACCC CTCTGACCTG CACCTCAATA GAGGGAACCA TGAAGACTTT 720

ATGATGAACC TGAGGTATGG CTTCACAAAA GAAATTTTAC AAAAATACAA GCTACACGGG 780

AGAAAAATCT TACAAGTCTT GGAAGAAGTC TATACCTGGC TCCCAATCGG TACAATTATT 840

GACAACGAAA TCCTGGTCAT ACATGGTGGG ATATCAGAAT CCACAGACTT GAATACACTC 900

CACCAGTTAC AAAGAAATAA AATGAAATCT GTGTTGATGC CGCCAGTGTT GGGAAATCAA 960

GAGACTGGCG AAAAGAGAAA TAAATCAGCG TCAAATTATG TTGAACCAAG GAAGGTTGAA 1020

CCAGACAAGA CTCCTTCTGA AGACTTGACA AAGCAAGAAT GGGAACAAAT AGTTGACATT 1080

CTGTGGAGTG ACCCCAGAGG CAAAAAAGGC TGTTATCCAA ACACAAGCCG AGGAGGGGGC 1140

TGCTATTTTG GACCAGATGT TACCTCTAAG GTTCTTAGTA AAAACCAGTT GAAGATGCTC 1200

ATTAGGTCTC ATGAGTGTAA ACCCGACGGG TATGAAGTCT CTCATGATGG AAAGGTCATT 1260

ACTGTATTTT CTGCTTCTAA TTATTATGAA GAAGGCAGCA ACCGAGGAGC TTACATCAGA 1320

CTAAGTTATG GTACAATGCC ACAATTTTTC CAGTACCAAG TAACTAGTAC ATCATGCCTG 1380

AACCCTCTTC ACCAAAGGAT GAATGCTATG GAATCCAGTG CTTTCAAGAT ACTAAAGGAA 1440

AAAATGATTT CACGAAAAAC TGATCTCATC AACGCTTTCG AGCTCCGTGA CCACAGTAGG 1500

TCAGGAAGGA TTTCATTGGC CGAGTGGGCA TTTTCTATGG AGAACATTTT GGGGCTGAAC 1560

TTACCATGGA GATCTCTAAG TTCACACCTG GTAACCATTG ATTCCAGCGG AAGTGTTGAC 1620

TACATGTCCA GCTTTGACGA TATCCGTATT GAAAAGCCTA CGAAAGATAT GAAGTCCAAT 1680

CTAACTGAAA CTATGTACAG ATACCGATCT GACCTGAAAA TCATATTTAA TATCATCGAC 1740

AGTGATCAAT CAGGTCTGAT CTCCATGGAT GAATTTCGGA CCATGTGGAA ACTTTTCAAT 1800

GCTCATTACA AAGCTCATAT AGATGATTCC CAAATTGATG AGCTTGCCAG CATAGTGGAC 1860

TTCAACAAAG ATGGCAACAT CGACTTTAAT GAGTTTTTAA AGGCTTTCTA TGTAGTACAT 1920

AAATATGATA AGCCAGGGAC CAGTCTTGCT TAA 1953

Domain Profile

S: 1     idlllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddl  60

         i +ll++fk+++ilha+yvlevlfea+kvlkq+pn+shv+t ++ke+t++GdlhGklddl

Q: 124   IHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDL  183

         679*********************************************************

S: 61    llvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn  120

         +l+++knGlPse+npyvfnGdfvdrG++++e+l++ll+ flv+P +++lnrGnhed++mn

Q: 184   MLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMN  243

         ************************************************************

S: 121   aryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksv  180

         +ryGf+ke+l+kyk +g++il++leevy+wlP+g+i+d+++lv+hGG+sest+l+ l+++

Q: 244   LRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQL  303

         ************************************************************

S: 181   erkkrksvllpPeessrd..............lgrldtdgepreslteteweqiidilws  226

         +r+k+ksvl+pP   +++                +++ d  p+e+lt++eweqi+dilws

Q: 304   QRNKMKSVLMPPVLGNQEtgekrnksasnyvePRKVEPDKTPSEDLTKQEWEQIVDILWS  363

         *************999999999*******9987899************************

S: 227   dPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtif  286

         dPr+++G++Pnt rG+G+yfGPdvt+++l k +lk++irsheckp+gye+ hdgkv+t+f

Q: 364   DPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGKVITVF  423

         ************************************************************

S: 287   sasnyyeegsnkgayiklnsqltprfvqyiva  318

         sasnyyeegsn+gayi+l+ +++p+f+qy+v+

Q: 424   SASNYYEEGSNRGAYIRLSYGTMPQFFQYQVT  455

         ******************************98

Domain Sequence
(FASTA)

IHILLQAFKQ QQILHAHYVL EVLFEARKVL KQMPNFSHVK TFPAKEITIC GDLHGKLDDL 60

MLIFYKNGLP SENNPYVFNG DFVDRGNNSM EILMILLVCF LVYPSDLHLN RGNHEDFMMN 120

LRYGFTKEIL QKYKLHGRKI LQVLEEVYTW LPIGTIIDNE ILVIHGGISE STDLNTLHQL 180

QRNKMKSVLM PPVLGNQETG EKRNKSASNY VEPRKVEPDK TPSEDLTKQE WEQIVDILWS 240

DPRGKKGCYP NTSRGGGCYF GPDVTSKVLS KNQLKMLIRS HECKPDGYEV SHDGKVITVF 300

SASNYYEEGS NRGAYIRLSY GTMPQFFQYQ VT 332

Keyword

Complete proteome; Hydrolase; Iron; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

mmu:237178

;

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; FALSE_NEG.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013