EKS-MUM-00182
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00182
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/SRPK884.74.3E-26679680602
StatusReviewed
Ensembl ProteinENSMUSP00000085734
UniProt AccessionO54781; Q8VCD9;
Protein NameSRSF protein kinase 2 C-terminal
Protein Synonyms/Alias SFRS protein kinase 2; Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2;
Gene NameSrpk2
Gene Synonyms/Alias Srpk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000062604ENSMUSP00000085734ENSMUST00000088392
OrganismMus musculus
Functional DescriptionSerine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in splicesomal B complex formation via the phosphorylation of DDX23/PRP28.
Protein Length682
Protein Sequence
(FASTA)
MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPLPDPAP PEPEEEILGS DDEEQEDPAD 60
YCKGGYHPVK IGDLFNGRYH VIRKLGWGHF STVWLCWDMQ GKRFVAMKVV KSAQHYTETA 120
LDEIKLLKCV RESDPSDPNK DMVVQLIDDF KISGMNGIHV CMVFEVLGHH LLKWIIKSNY 180
QGLPVRCVKS IIRQVLQGLD YLHSKCKIIH TDIKPENILM CVDDAYVRRM AAEATEWQKA 240
GAPPPSGSAV STAPQQKPIG KISKNKKKKL KKKQKRQAEL LEKRLQEIEE LEREAERKIL 300
EENITSAEAS GEQQDGEYQP EVTLKAADLE DTTEEETAKD NGEVEDQEEK EDAEKENAEK 360
DEDDVEQELA NLDPTWVESP KANGHIENGP FSLEQQLEDE EDDEDDCANP EEYNLDEPNA 420
ESDYTYSSSY EQFNGELPNG QHKTSEFPTP LFSGPLEPVA CGSVISEGSP LTEQEESSPS 480
HDRSRTVSAS STGDLPKTKT RAADLLVNPL DPRNADKIRV KIADLGNACW VHKHFTEDIQ 540
TRQYRSIEVL IGAGYSTPAD IWSTACMAFE LATGDYLFEP HSGEDYSRDE DHIAHIIELL 600
GSIPRHFALS GKYSREFFNR RGELRHITKL KPWSLFDVLV EKYGWPHEDA AQFTDFLIPM 660
LEMVPEKRAS AGECLRHPWL NS 682
Nucleotide Sequence
(FASTA)
ATGTCAGTTA ACTCTGAGAA GTCGTCCTCT TCAGAAAGGC CGGAGCCTCA ACAGAAAGCT 60
CCTTTAGTTC CTCCTCCTCC ACCACCACCA CCGCCACCAC CACTGCCAGA CCCCGCACCC 120
CCAGAGCCAG AGGAGGAGAT TCTGGGGTCA GATGATGAGG AGCAGGAGGA CCCCGCAGAT 180
TACTGCAAAG GTGGCTATCA TCCAGTGAAA ATTGGAGATC TCTTCAATGG TCGATATCAT 240
GTCATTAGAA AGCTAGGATG GGGGCACTTT TCTACTGTAT GGCTGTGCTG GGATATGCAA 300
GGGAAAAGAT TTGTTGCAAT GAAAGTTGTA AAAAGTGCCC AGCATTATAC AGAGACAGCC 360
TTGGATGAAA TTAAACTACT CAAATGCGTT CGAGAAAGTG ACCCCAGTGA CCCAAACAAA 420
GACATGGTAG TTCAGCTAAT TGATGACTTC AAGATCTCAG GCATGAATGG GATACATGTC 480
TGCATGGTCT TTGAAGTACT TGGTCACCAT CTCCTCAAAT GGATCATCAA ATCCAACTAT 540
CAAGGCCTCC CAGTACGTTG TGTGAAGAGT ATCATTCGAC AGGTCCTTCA AGGGTTAGAT 600
TATCTACACA GTAAGTGCAA GATAATTCAC ACCGACATAA AGCCGGAAAA CATCTTGATG 660
TGTGTGGATG ACGCTTACGT GAGAAGAATG GCAGCCGAAG CCACGGAGTG GCAGAAAGCA 720
GGTGCTCCTC CTCCCTCTGG GTCTGCAGTG AGTACGGCTC CACAGCAAAA ACCTATAGGA 780
AAAATATCTA AAAACAAAAA GAAAAAGCTG AAAAAGAAAC AGAAGAGACA GGCTGAGTTG 840
CTGGAGAAAC GCCTACAGGA GATTGAGGAA TTGGAGCGAG AAGCCGAAAG GAAAATCCTA 900
GAGGAGAACA TCACCTCTGC AGAAGCTTCC GGGGAGCAGC AGGATGGAGA GTACCAGCCG 960
GAGGTGACAC TGAAAGCAGC CGACTTAGAG GACACAACTG AGGAAGAGAC AGCAAAGGAT 1020
AATGGTGAAG TTGAAGACCA GGAAGAGAAA GAAGATGCAG AGAAGGAGAA CGCGGAGAAG 1080
GATGAAGATG ATGTTGAACA GGAACTTGCA AACTTAGACC CTACCTGGGT GGAGTCCCCG 1140
AAAGCCAATG GCCATATTGA AAATGGCCCG TTCTCACTGG AGCAGCAGCT GGAGGATGAA 1200
GAGGACGATG AAGATGACTG TGCAAATCCC GAGGAGTATA ACCTCGATGA GCCAAATGCA 1260
GAGAGTGATT ACACGTATAG CAGCTCCTAT GAACAATTCA ATGGTGAATT GCCAAATGGA 1320
CAACATAAGA CTTCAGAGTT TCCCACACCG TTGTTTTCTG GGCCCTTAGA ACCTGTGGCC 1380
TGTGGCTCTG TGATTTCAGA GGGATCGCCA CTTACCGAGC AGGAGGAAAG CAGTCCCTCC 1440
CATGACAGAA GCAGGACAGT TTCAGCCTCT AGTACTGGAG ATTTGCCAAA AACAAAAACC 1500
CGGGCGGCTG ACCTGTTGGT GAACCCTCTG GATCCACGGA ATGCAGATAA AATTAGAGTA 1560
AAAATTGCTG ACCTGGGAAA TGCTTGTTGG GTGCATAAAC ATTTCACAGA GGATATCCAG 1620
ACACGTCAGT ATAGGTCCAT AGAGGTTTTA ATAGGAGCAG GCTACAGCAC ACCTGCAGAC 1680
ATTTGGAGTA CAGCTTGCAT GGCATTTGAG CTCGCCACAG GAGACTATTT GTTCGAACCG 1740
CATTCTGGGG AAGACTATTC CAGAGATGAA GACCACATAG CCCACATCAT AGAGCTGCTA 1800
GGCAGTATCC CAAGGCACTT TGCTCTGTCT GGAAAATATT CTCGGGAATT CTTCAATCGC 1860
AGAGGAGAAC TGCGGCACAT CACCAAGCTG AAGCCCTGGA GCCTCTTTGA TGTACTTGTG 1920
GAAAAGTATG GCTGGCCCCA TGAAGATGCT GCACAATTTA CAGATTTCCT GATCCCAATG 1980
TTAGAGATGG TTCCAGAAAA ACGAGCCTCA GCTGGCGAAT GCCTTCGACA TCCTTGGTTG 2040
AATTCTTAG 2049
Domain Profile
S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60
         yhvirkLGWGhfstvWL+wd+q+krfva+kvvksa+hytetaldeikllk+vresdpsdp
Q: 79    YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP  138
         9***********************************************************
S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120
         ++++vvql+ddfkisG+nG+hvc+vfevLG++Llk+iiksny+Glp+++vk+iirqvL+g
Q: 139   NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG  198
         ************************************************************
S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180
         Ldylh+kCkiihtdikPen+L++vdd+y+rr+aaeatewqkaga+ppsgsavstapq+k+
Q: 199   LDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKP  258
         ************************************************************
S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214
         i+k+sknkkkklkkkqkrqaellekrlqe+eele                          
Q: 259   IGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEreaerkileenitsaeasgeqqdgey  318
         ************************************************************
S: 215   ..................aaeanseaedqelkedaekgeleeieadveeevanedea...  253
                           +a++n+e+edqe+kedaek+++e++e+dve+e+an d++   
Q: 319   qpevtlkaadledtteeeTAKDNGEVEDQEEKEDAEKENAEKDEDDVEQELANLDPTwve  378
         *********************************************************888
S: 254   .....................seeee...................essltsssdaesksg  273
                              +   e                   es++t+ss++e+++g
Q: 379   spkanghiengpfsleqqledE---EddeddcanpeeynldepnaESDYTYSSSYEQFNG  435
         8888888888888777766551...04557778888888888899***************
S: 274   el.......seastellsesleqlacgsvls.............................  297
         el       se++t+l+s++le++acgsv+s                             
Q: 436   ELpngqhktSEFPTPLFSGPLEPVACGSVISegsplteqeesspshdrsrtvsasstgdl  495
         **99**9999**************************************************
S: 298   ...........vnplepknadkikvkiadLGnaCwvhkhftediqtrqyrslevliGagy  346
                    vnpl+p+nadki+vkiadLGnaCwvhkhftediqtrqyrs+evliGagy
Q: 496   pktktraadllVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGY  555
         ************************************************************
S: 347   gtpadiWstaClafeLatGdyLfephsgedysrdedhiakiiellGkiPrklilkGkysr  406
         +tpadiWstaC+afeLatGdyLfephsgedysrdedhia+iiellG+iPr+++l+Gkysr
Q: 556   STPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSR  615
         ************************************************************
S: 407   effnkkgeLrhitkLkpwsLlevLvekyewskeeaaefsdfLlPmleldpekrasaaecl  466
         effn++geLrhitkLkpwsL++vLveky+w++e+aa+f+dfL+Pmle++pekrasa+ecl
Q: 616   EFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECL  675
         ************************************************************
S: 467   khpwL  471
         +hpwL
Q: 676   RHPWL  680
         ****8
Domain Sequence
(FASTA)
YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE TALDEIKLLK CVRESDPSDP 60
NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS NYQGLPVRCV KSIIRQVLQG 120
LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ KAGAPPPSGS AVSTAPQQKP 180
IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK ILEENITSAE ASGEQQDGEY 240
QPEVTLKAAD LEDTTEEETA KDNGEVEDQE EKEDAEKENA EKDEDDVEQE LANLDPTWVE 300
SPKANGHIEN GPFSLEQQLE DEEDDEDDCA NPEEYNLDEP NAESDYTYSS SYEQFNGELP 360
NGQHKTSEFP TPLFSGPLEP VACGSVISEG SPLTEQEESS PSHDRSRTVS ASSTGDLPKT 420
KTRAADLLVN PLDPRNADKI RVKIADLGNA CWVHKHFTED IQTRQYRSIE VLIGAGYSTP 480
ADIWSTACMA FELATGDYLF EPHSGEDYSR DEDHIAHIIE LLGSIPRHFA LSGKYSREFF 540
NRRGELRHIT KLKPWSLFDV LVEKYGWPHE DAAQFTDFLI PMLEMVPEKR ASAGECLRHP 600
WL 602
KeywordATP-binding; Complete proteome; Cytoplasm; Differentiation; Kinase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00169
EKS-ANC-00170
EKS-BOT-00177
EKS-CAJ-00181
EKS-CAF-00184
EKS-CAP-00204
EKS-CII-00116
EKS-EQC-00175
EKS-FEC-00167
EKS-GAM-00096
EKS-GAG-00153
EKS-GAA-00219
EKS-GOG-00176
EKS-HOS-00183
EKS-ICT-00173
EKS-LAC-00189
EKS-LOA-00176
EKS-MAM-00176
EKS-MEG-00139
EKS-MOD-00177
EKS-MUP-00180
EKS-MYL-00185
EKS-NOL-00170
EKS-ORN-00224
EKS-ORA-00156
EKS-ORC-00164
EKS-ORL-00209
EKS-OTG-00183
EKS-PAT-00167
EKS-PEM-00094
EKS-POA-00173
EKS-RAN-00173
EKS-SAH-00169
EKS-SUS-00156
EKS-TAG-00207
EKS-TAR-00230
EKS-TEN-00228
EKS-XET-00210
EKS-XIM-00219
EKS-SAC-00082
EKS-SCP-00104
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005730; C:nucleolus
GO:0005634; C:nucleus
GO:0071889; F:14-3-3 protein binding
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001525; P:angiogenesis
GO:0030154; P:cell differentiation
GO:0007243; P:intracellular protein kinase cascade
GO:0045071; P:negative regulation of viral genome replication
GO:0035063; P:nuclear speck organization
GO:0045787; P:positive regulation of cell cycle
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0045070; P:positive regulation of viral genome replication
GO:0000245; P:spliceosomal complex assembly
KEGG
mmu:20817;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013