| Tag | Content |
|---|
| EKPD ID | EPS-MUM-00108 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PTPLA/PTPLA | 193.7 | 4.7E-57 | 79 | 239 | 161 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000074397 |
| UniProt Accession | Q9QY80; Q9D6P7; |
| Protein Name | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1 |
| Protein Synonyms/Alias | 3-hydroxyacyl-CoA dehydratase 1; HACD1; Protein-tyrosine phosphatase-like member A; |
| Gene Name | Ptpla |
| Gene Synonyms/Alias | Ptpla; hacd1; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Responsible for the dehydration step in very long-chainfatty acids (VLCFAs) synthesis (By similarity). |
| Protein Length | 248 |
Protein Sequence
(FASTA) | | MASSEEDGTN GASEASDEKE AAGKRRRLGL LATAWLTFYN IAMTAGWLVL AIAMVRFYME 60 | | KGTHRGLYKS IQKTLKFFQT FALLEVVHCL IGIVPTSVLV TGVQVSSRIF MVWLITHSIK 120 | | PIQNEESVVL FLVSWTVTEI TRYSFYTFSL LDHLPHFIKW ARYNLFIILY PVGVAGELLT 180 | | IYAALPYVKK SGMFSVRLPN KYNVSFDYYY FLLITMASYI PLFPQLYFHM LRQRRKVLHG 240 | | EVIAEKDD 248 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGTCCA GTGAGGAGGA CGGCACCAAC GGCGCCTCCG AGGCCAGCGA CGAGAAGGAA 60 | | GCCGCCGGCA AGCGGAGACG CCTAGGCTTA CTGGCCACCG CCTGGCTCAC CTTCTACAAT 120 | | ATCGCCATGA CGGCCGGGTG GTTGGTTCTT GCTATTGCTA TGGTACGCTT TTATATGGAA 180 | | AAAGGAACAC ACAGAGGTTT ATATAAAAGC ATTCAGAAGA CACTTAAGTT TTTCCAAACA 240 | | TTTGCTTTGC TTGAGGTAGT CCATTGTCTG ATCGGAATTG TACCCACTTC TGTGCTTGTG 300 | | ACTGGGGTCC AAGTGAGCTC AAGAATCTTC ATGGTGTGGC TCATTACTCA CAGTATAAAA 360 | | CCCATCCAGA ATGAAGAGAG CGTGGTGCTT TTTCTGGTCT CCTGGACTGT GACCGAGATC 420 | | ACTCGCTATT CCTTCTACAC ATTCAGTCTC CTCGACCACT TGCCGCACTT CATTAAATGG 480 | | GCCAGATACA ATTTGTTTAT CATCTTATAT CCCGTTGGAG TTGCTGGGGA ACTTCTCACA 540 | | ATATACGCCG CCTTGCCTTA CGTAAAGAAG TCAGGAATGT TCTCAGTACG GCTTCCCAAC 600 | | AAGTACAATG TTTCTTTTGA CTACTACTAT TTTCTTCTCA TAACCATGGC CTCCTATATA 660 | | CCGTTGTTTC CTCAGCTCTA TTTTCATATG TTACGTCAGA GAAGAAAGGT GCTCCACGGG 720 | | GAGGTGATCG CGGAGAAGGA CGATTAA 747 |
|
| Domain Profile | S: 1 qtlavlEivhallglvrspvlttllQvasRllivwvvveslpevqnspvvlllllaWslt 60 | qt+a+lE+vh+l+g+v+++vl+t +Qv+sR+++vw++++s++ +qn+ v+l+l++W++t | Q: 79 QTFALLEVVHCLIGIVPTSVLVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVSWTVT 138 | 9*********************************************************** |
| S: 61 EviRYsfyalkllgtepklltwlRYslFivLYPlGvlsEavlvyqslpvlketkrfslkl 120 | E+ RYsfy+++ll++ p++++w RY+lFi+LYP+Gv++E++++y++lp++k++ +fs++l | Q: 139 EITRYSFYTFSLLDHLPHFIKWARYNLFIILYPVGVAGELLTIYAALPYVKKSGMFSVRL 198 | ************************************************************ |
| S: 121 paalnfslsfsyflilvlllyipglyvlytymlkqrkkvlk 161 | p+++n+s++++yfl + ++ yip +++ly +ml+qr+kvl+ | Q: 199 PNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLH 239 | ***************************************97 |
|
Domain Sequence
(FASTA) | | QTFALLEVVH CLIGIVPTSV LVTGVQVSSR IFMVWLITHS IKPIQNEESV VLFLVSWTVT 60 | | EITRYSFYTF SLLDHLPHFI KWARYNLFII LYPVGVAGEL LTIYAALPYV KKSGMFSVRL 120 | | PNKYNVSFDY YYFLLITMAS YIPLFPQLYF HMLRQRRKVL H 161 |
|
| Keyword | Complete proteome; Developmental protein; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |