EKS-MUM-00501
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00501
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK364.77.8E-10915305291
StatusReviewed
Ensembl ProteinENSMUSP00000087098
UniProt AccessionQ80Y86;
Protein NameMitogen-activated protein kinase 15
Protein Synonyms/Alias MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7;
Gene NameMapk15
Gene Synonyms/Alias Mapk15; Erk7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000063704ENSMUSP00000087098ENSMUST00000089669
OrganismMus musculus
Functional DescriptionConstitutively active kinase which may function as anegative regulator of cell growth (By similarity).
Protein Length549
Protein Sequence
(FASTA)
MCAAEVDRHV AQRYLIKRRL GKGAYGIVWK AMDRRTGEVV AIKKIFDAFR DQIDAQRTFR 60
EIMLLKEFGG HPNIIRLLDV IPAKNDRDIY LVFESMDTDL NAVIQKGRLL KDIHKRCIFY 120
QLLRATKFIH SGRVIHRDQK PANVLLDSAC RVKLCDFGLA RSLGDLPEGP GGQALTEYVA 180
TRWYRAPEVL LSSRWYTPGV DMWSLGCILG EMLRGQPLFP GTSTFHQLEL ILKTIPLPSM 240
EELQDLGSDY SALILQNLGS RPQQTLDALL PPDTPPEALD LLKRLLAFAP DKRLSAEQAL 300
QHPYVQRFHC PDREWARESD VRLPVHEGDQ LSAPEYRKRL YQIILEQSGN SRSPREEGLG 360
VVASRAELRA SPARTQSLKS GVLPQVPAET PARKRGPKPP RSPGHDPEHV EVRRQSSDPL 420
FQLPPPGRGE RPPGATGQPP SAPSGVKTQV RAMAPSLTSQ AEAQAANQAL IRSDPARGGG 480
PRAVGARRVP SRLPREAPEP RPGRRMFGIS VSQGAQGAAR AALGGYSQAY GTVCRSALGR 540
LPLLPGPRA 549
Nucleotide Sequence
(FASTA)
ATGTGTGCTG CCGAGGTGGA CCGTCATGTA GCCCAGAGAT ACCTGATCAA GCGGAGGCTT 60
GGGAAGGGGG CCTATGGCAT TGTGTGGAAG GCCATGGACC GGAGGACTGG CGAGGTTGTG 120
GCCATCAAGA AAATCTTTGA TGCCTTTAGG GACCAGATAG ATGCTCAGAG GACCTTCCGT 180
GAGATTATGC TTCTCAAGGA GTTTGGAGGC CATCCCAACA TCATCCGCCT GCTTGATGTA 240
ATCCCAGCGA AGAATGACAG GGATATTTAC CTGGTGTTTG AGTCCATGGA CACCGACCTG 300
AATGCAGTCA TCCAGAAGGG CAGACTACTG AAGGACATCC ACAAGCGGTG CATCTTTTAC 360
CAGCTCCTGA GAGCCACCAA GTTTATCCAT TCAGGGCGCG TCATCCATCG GGATCAGAAG 420
CCAGCCAATG TTCTACTGGA TTCTGCTTGC CGGGTGAAAC TCTGTGACTT TGGCCTGGCA 480
CGCTCCCTCG GTGACCTCCC TGAGGGGCCT GGGGGTCAGG CCCTGACAGA GTATGTGGCC 540
ACACGCTGGT ACCGAGCTCC AGAGGTGCTT CTGTCTTCCC GATGGTATAC CCCTGGGGTG 600
GACATGTGGA GCCTGGGCTG CATATTAGGA GAGATGCTTC GAGGGCAGCC ACTGTTTCCC 660
GGGACATCTA CTTTCCACCA GCTGGAGCTG ATCCTGAAGA CCATCCCATT GCCTTCCATG 720
GAGGAGCTCC AGGACCTTGG CTCAGACTAC AGTGCTTTGA TTCTGCAGAA TCTTGGGTCC 780
AGGCCACAGC AGACGCTGGA CGCCCTCCTG CCGCCAGACA CCCCCCCAGA AGCCCTGGAC 840
CTCCTCAAGC GACTCTTGGC GTTTGCTCCG GACAAGCGCC TTAGTGCAGA GCAGGCGCTG 900
CAACACCCCT ACGTGCAGAG ATTCCATTGC CCCGACCGCG AGTGGGCACG GGAGTCCGAC 960
GTGCGGCTCC CGGTGCACGA AGGAGACCAG CTCTCTGCAC CAGAGTATCG CAAACGCCTG 1020
TACCAGATTA TCCTGGAGCA AAGTGGGAAC AGCCGCAGCC CTCGAGAGGA AGGCCTGGGG 1080
GTTGTGGCCT CGCGGGCTGA GCTCAGGGCT TCCCCGGCCC GGACGCAATC GCTCAAGTCG 1140
GGAGTCCTCC CCCAGGTCCC GGCGGAGACG CCAGCGCGAA AACGCGGACC CAAACCTCCG 1200
CGTAGCCCTG GTCATGATCC TGAGCATGTG GAAGTTCGCA GGCAGAGCTC AGACCCCCTG 1260
TTCCAACTTC CGCCGCCAGG AAGGGGGGAA AGGCCCCCAG GGGCCACAGG GCAGCCACCC 1320
TCGGCACCCT CAGGGGTGAA GACTCAAGTG AGGGCGATGG CGCCGTCCCT GACTTCACAG 1380
GCAGAGGCTC AGGCGGCCAA TCAGGCTCTG ATCCGCAGTG ATCCGGCCCG GGGCGGTGGG 1440
CCGAGGGCGG TCGGCGCGCG ACGGGTCCCT TCCCGCCTGC CCCGGGAGGC CCCGGAACCC 1500
CGACCCGGCC GAAGGATGTT TGGCATCTCG GTCTCGCAGG GGGCCCAGGG CGCAGCCAGA 1560
GCTGCGCTTG GCGGCTACTC CCAGGCCTAC GGGACCGTGT GCCGCTCGGC GCTGGGCCGC 1620
CTGCCCCTGC TCCCCGGACC GCGTGCGTGA 1650
Domain Profile
S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60
           +++lg+Gayg+v++a+d+rt+e vaikk++++f+++++a+rt+RE++llke+  h+Ni
Q: 15    LIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQIDAQRTFREIMLLKEFgGHPNI  74
         56789*************************************************99****
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119
         i+lldv+ +++     +d+Ylv+e m+tdL++vi++   l+d h ++++yq+lr++k++H
Q: 75    IRLLDVIPAKN----DRDIYLVFESMDTDLNAVIQKGrLLKDIHKRCIFYQLLRATKFIH  130
         *******9888....9********************978999******************
S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175
         s +viHrD+KP+N+l+++ c++k++dFGlars  +  e      lteyvatrwYraPe+l
Q: 131   SGRVIHRDQKPANVLLDSACRVKLCDFGLARSLGDLPEGPggqaLTEYVATRWYRAPEVL  190
         ********************************999887778889****************
S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235
         ls++ yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+il++++ ps e l+++ s+ 
Q: 191   LSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILKTIPLPSMEELQDLGSDY  250
         ************************************************************
S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289
          + ++++l +++++++++l+p  + +ealdLl++lL ++pdkR+s+e+aL+hpY+
Q: 251   SALILQNLGSRPQQTLDALLPPdTPPEALDLLKRLLAFAPDKRLSAEQALQHPYV  305
         *******************9875889****************************7
Domain Sequence
(FASTA)
LIKRRLGKGA YGIVWKAMDR RTGEVVAIKK IFDAFRDQID AQRTFREIML LKEFGGHPNI 60
IRLLDVIPAK NDRDIYLVFE SMDTDLNAVI QKGRLLKDIH KRCIFYQLLR ATKFIHSGRV 120
IHRDQKPANV LLDSACRVKL CDFGLARSLG DLPEGPGGQA LTEYVATRWY RAPEVLLSSR 180
WYTPGVDMWS LGCILGEMLR GQPLFPGTST FHQLELILKT IPLPSMEELQ DLGSDYSALI 240
LQNLGSRPQQ TLDALLPPDT PPEALDLLKR LLAFAPDKRL SAEQALQHPY V 291
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00438
EKS-ANC-00459
EKS-BOT-00470
EKS-CAE-00391
EKS-CAJ-00479
EKS-CAF-00469
EKS-CAP-00501
EKS-CII-00263
EKS-CIS-00223
EKS-DAR-00878
EKS-DRM-00226
EKS-FEC-00447
EKS-GAM-00273
EKS-GAG-00390
EKS-GAA-00570
EKS-GOG-00458
EKS-HOS-00476
EKS-ICT-00445
EKS-LAC-00483
EKS-MAM-00465
EKS-MEG-00383
EKS-MOD-00462
EKS-NOL-00430
EKS-ORA-00409
EKS-ORC-00444
EKS-ORL-00538
EKS-OTG-00476
EKS-PES-00415
EKS-PEM-00257
EKS-POA-00456
EKS-RAN-00482
EKS-SAH-00438
EKS-TAR-00583
EKS-TEN-00589
EKS-TUT-00174
EKS-XET-00617
EKS-XIM-00585
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0008156; P:negative regulation of DNA replication
GO:0045732; P:positive regulation of protein catabolic process
GO:0001934; P:positive regulation of protein phosphorylation
GO:0031398; P:positive regulation of protein ubiquitination
GO:0046777; P:protein autophosphorylation
GO:0032355; P:response to estradiol stimulus
KEGG
mmu:332110;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013