EKS-MUM-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	387.5	9.1E-116	203	501	299

Status

Reviewed

Ensembl Protein

ENSMUSP00000084701

UniProt Accession

O35607;

Protein Name

Bone morphogenetic protein receptor type-2

Protein Synonyms/Alias

BMP type-2 receptor; BMPR-2; BRK-3; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II;

Gene Name

Bmpr2

Gene Synonyms/Alias

Bmpr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000067336	ENSMUSP00000084701	ENSMUST00000087435

Organism

Mus musculus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Protein Length

1038

Protein Sequence
(FASTA)

MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60

SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120

DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180

QGLHSMNMME AAAAEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240

INEKNIYRVP LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300

SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS DFGLSMRLTG 360

NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEVFMRC 420

TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480

EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 540

GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 600

PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG PTPVCLQLTE 660

EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 720

QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN 780

LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA 840

HRSQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 900

NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD GSSIQIGEST 960

QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV NNNGSDRAVH SKSSTAVYLA 1020

EGGTATTTVS KDIGMNCL 1038

Nucleotide Sequence
(FASTA)

ATGACTTCCT CGCTGCATCG GCCCTTTCGG GTGCCCTGGC TGCTATGGGC CGTCCTGCTG 60

GTCAGCACTA CGGCTGCTTC TCAGAATCAA GAACGGCTGT GTGCATTTAA AGATCCATAT 120

CAACAAGATC TTGGGATAGG TGAGAGTCGA ATCTCTCATG AAAATGGGAC AATATTATGT 180

TCCAAAGGGA GCACGTGTTA TGGTCTGTGG GAGAAATCAA AAGGGGACAT CAATCTTGTG 240

AAACAAGGAT GTTGGTCTCA CATCGGTGAT CCCCAAGAGT GCCACTATGA AGAGTGTGTA 300

GTAACTACCA CCCCACCCTC AATTCAGAAT GGAACGTACC GCTTTTGCTG CTGTAGTACA 360

GATTTATGTA ATGTCAACTT TACTGAGAAC TTTCCACCCC CTGACACAAC ACCACTCAGT 420

CCACCTCATT CATTTAATCG AGATGAAACG ATAATCATTG CTTTGGCATC AGTTTCTGTG 480

TTAGCTGTTT TGATAGTCGC CTTATGTTTT GGATACAGAA TGTTGACAGG AGACCGGAAA 540

CAGGGTCTTC ACAGCATGAA CATGATGGAG GCGGCAGCAG CAGAGCCCTC CCTTGACCTG 600

GATAACCTGA AGCTGCTGGA GCTGATTGGA CGGGGTCGAT ACGGAGCAGT ATATAAAGGT 660

TCCTTGGATG AGCGTCCAGT TGCTGTAAAA GTATTTTCTT TTGCAAACCG TCAGAATTTT 720

ATAAATGAAA AAAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCTCGCTTC 780

ATAGTTGGAG ACGAGAGGCT CACTGCAGAC GGCCGCATGG AGTATTTGCT TGTGATGGAG 840

TATTATCCCA ATGGATCTCT GTGCAAATAT CTGAGTCTCC ACACAAGTGA TTGGGTAAGC 900

TCTTGCCGTC TGGCTCATTC TGTGACTAGA GGACTGGCTT ATCTTCACAC AGAATTACCA 960

CGAGGAGATC ATTATAAACC CGCAATCTCC CACCGAGATT TAAACAGCAG GAATGTCCTG 1020

GTAAAGAATG ACGGCGCGTG TGTTATCAGT GACTTTGGTT TATCCATGAG GCTAACTGGA 1080

AATCGGCTGG TGCGCCCAGG GGAAGAAGAT AATGCGGCTA TAAGTGAGGT TGGCACAATT 1140

CGCTATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACC TGAGGGACTG TGAGTCAGCT 1200

CTGAAGCAAG TGGACATGTA TGCGCTTGGA CTCATCTACT GGGAGGTGTT TATGAGGTGT 1260

ACAGACCTCT TCCCAGGTGA ATCTGTACCA GATTACCAGA TGGCTTTTCA GACAGAAGTT 1320

GGAAACCATC CCACATTTGA GGATATGCAG GTTCTTGTGT CCAGAGAGAA GCAGAGACCC 1380

AAGTTCCCAG AAGCCTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA GGAAACAATT 1440

GAAGACTGCT GGGACCAGGA TGCAGAGGCT CGGCTCACTG CACAGTGTGC TGAGGAGAGG 1500

ATGGCTGAAC TCATGATGAT ATGGGAGAGA AACAAGTCTG TGAGCCCAAC GGTCAACCCA 1560

ATGTCAACTG CTATGCAGAA TGAACGCAAC CTGTCACATA ATAGGCGTGT GCCAAAAATC 1620

GGGCCTTACC CAGATTATTC CTCTTCCTCA TATATTGAAG ACTCTATCCA TCATACTGAC 1680

AGCATTGTGA AGAATATTTC CTCTGAGCAT TCGATGTCCA GCACACCATT GACAATAGGA 1740

GAAAAGAATC GAAATTCAAT TAATTATGAA CGACAGCAAG CACAAGCTCG AATCCCTAGC 1800

CCAGAAACAA GCGTCACAAG CCTGTCCACA AACACAACCA CCACAAACAC CACCGGCCTC 1860

ACTCCAAGTA CTGGCATGAC CACTATATCT GAGATGCCAT ACCCAGATGA GACACATTTG 1920

CACGCCACAA ATGTTGCACA GTCAATCGGG CCAACCCCTG TCTGCTTACA GCTGACAGAA 1980

GAAGACTTGG AGACTAATAA GCTAGATCCA AAAGAAGTTG ATAAGAACCT CAAGGAAAGC 2040

TCTGATGAGA ATCTCATGGA GCATTCTCTG AAGCAGTTCA GTGGGCCAGA CCCATTGAGC 2100

AGTACCAGTT CTAGCTTGCT TTATCCACTC ATAAAGCTCG CAGTGGAAGT GACTGGACAA 2160

CAGGACTTCA CACAGGCTGC AAATGGGCAA GCATGTTTAA TTCCTGATGT TCCACCTGCT 2220

CAGATCTATC CTCTCCCTAA GCAACAGAAC CTTCCTAAGA GACCTACTAG TTTGCCTTTG 2280

AACACCAAAA ATTCAACAAA AGAACCCCGG CTAAAATTTG GCAACAAGCA CAAATCAAAC 2340

TTGAAACAAG TAGAAACTGG AGTTGCCAAG ATGAATACAA TCAATGCAGC AGAGCCTCAT 2400

GTGGTGACAG TAACTATGAA TGGTGTGGCA GGTAGAAGCC ACAATGTTAA TTCCCATGCT 2460

GCCACAACCC AGTATGCCAA TGGCGCAGTG CCAGCTGGCC AGGCAGCCAA CATAGTGGCA 2520

CATAGGTCCC AAGAAATGCT GCAGAATCAA TTTATTGGTG AGGATACCAG GCTGAATATC 2580

AATTCCAGTC CTGATGAGCA TGAACCTTTA CTGAGACGAG AGCAACAGGC TGGCCATGAT 2640

GAAGGGGTTC TGGATCGTTT GGTAGATAGG AGGGAACGGC CATTAGAAGG TGGCCGAACA 2700

AATTCCAATA ACAACAACAG CAATCCATGT TCAGAACAAG ATATCCTTAC ACAAGGTGTT 2760

ACAAGCACAG CTGCAGATCC TGGGCCATCA AAGCCCAGAA GAGCACAGAG GCCCAATTCT 2820

CTGGATCTTT CAGCCACAAA TATCCTGGAT GGCAGCAGTA TACAGATAGG TGAGTCAACA 2880

CAAGATGGCA AATCAGGATC AGGTGAAAAG ATCAAGAGAC GTGTGAAAAC TCCATACTCT 2940

CTTAAGCGGT GGCGCCCGTC CACCTGGGTC ATCTCCACCG AGCCGCTGGA CTGTGAGGTC 3000

AACAACAATG GCAGTGACAG GGCAGTCCAT TCTAAATCTA GCACTGCTGT GTACCTTGCA 3060

GAGGGAGGCA CTGCCACGAC CACAGTGTCT AAAGATATAG GAATGAATTG TCTGTGA 3117

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 263   GDErLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d++c+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 323   -DHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WEv++Rc++  ++e+v++y+++f+++vg

Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEVFMRCTDlfPGESVPDYQMAFQTEVG  441

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERLTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGACVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEVFMRCTD LFPGESVPDY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0009925	; C:basal plasma membrane
GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0030425	; C:dendrite
GO:0005887	; C:integral to plasma membrane
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007420	; P:brain development
GO:0009267	; P:cellular response to starvation
GO:0048286	; P:lung alveolus development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0001707	; P:mesoderm formation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0003085	; P:negative regulation of systemic arterial blood pressure
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0014916	; P:regulation of lung blood pressure
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841	; P:venous blood vessel development

KEGG

mmu:12168

;

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013