| Tag | Content |
|---|
| EKPD ID | EPS-MUM-00010 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 146.2 | 1.5E-42 | 5 | 141 | 137 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000089260 |
| UniProt Accession | Q99N11; Q5SQN9; Q5SQP0; |
| Protein Name | Dual specificity protein phosphatase 22 |
| Protein Synonyms/Alias | Low molecular weight dual specificity phosphatase 2; LMW-DSP2; |
| Gene Name | Dusp22 |
| Gene Synonyms/Alias | Dusp22; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Activates the Jnk signaling pathway. Dephosphorylatesand deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). |
| Protein Length | 184 |
Protein Sequence
(FASTA) | | MGSGMSQILP GLYIGNFKDA RDAEQLSRNK VTHILSVHDT ARPMLEGVKY LCIPAADTPS 60 | | QNLTRHFKES IKFIHECRLQ GESCLVHCLA GVSRSVTLVI AYIMTVTDFG WEDALHTVRA 120 | | GRSCANPNLG FQRQLQEFEK HEVHQYRQWL REEYGENPLR DAEEAKNILA APGILKYWAF 180 | | LRRL 184 |
|
Nucleotide Sequence
(FASTA) | | ATGGGGAGTG GGATGAGCCA GATCCTGCCG GGCCTGTACA TTGGCAACTT CAAAGACGCA 60 | | AGAGATGCAG AACAGTTGAG CAGGAACAAG GTGACACACA TTCTTTCTGT GCACGATACT 120 | | GCCAGGCCCA TGTTGGAGGG AGTTAAATAC CTGTGTATTC CAGCGGCAGA CACACCATCT 180 | | CAAAACCTGA CAAGACATTT CAAAGAAAGC ATTAAATTCA TTCATGAGTG CCGACTCCAG 240 | | GGTGAGAGCT GTCTTGTACA TTGCCTGGCT GGGGTCTCCA GGAGTGTGAC ATTGGTGATC 300 | | GCATACATCA TGACTGTCAC CGACTTTGGC TGGGAAGATG CCTTGCACAC TGTTCGTGCG 360 | | GGGAGGTCCT GTGCCAACCC CAACCTGGGC TTTCAAAGGC AGCTGCAGGA GTTTGAGAAA 420 | | CATGAAGTGC ACCAGTATCG GCAATGGCTG AGAGAAGAGT ATGGAGAGAA CCCTTTGCGG 480 | | GATGCAGAAG AAGCCAAAAA TATTCTGGCT GCCCCGGGAA TTCTGAAGTA CTGGGCCTTT 540 | | CTCAGAAGAC TGTAA 555 |
|
| Domain Profile | S: 2 vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd 61 | +++ilpgly+g+ ++a d +Ls++++t+++ + + + P + +g++y+ ip+ | Q: 5 MSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDT-AR----P---MLEGVKYLCIPAA 56 | 589***********************9999976544.44....2...459********** |
| S: 62 DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie 121 | D+++++l ++f+e ++fi+e++ +g+++lvHC aGvsRS+tlv+aY+m+v+++ ++dA++ | Q: 57 DTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALH 116 | ************************************************************ |
| S: 122 avkrkrpsiepnegfleQLlelekk 146 | +v++ r++++pn gf +QL e+ek+ | Q: 117 TVRAGRSCANPNLGFQRQLQEFEKH 141 | ***********************96 |
|
Domain Sequence
(FASTA) | | MSQILPGLYI GNFKDARDAE QLSRNKVTHI LSVHDTARPM LEGVKYLCIP AADTPSQNLT 60 | | RHFKESIKFI HECRLQGESC LVHCLAGVSR SVTLVIAYIM TVTDFGWEDA LHTVRAGRSC 120 | | ANPNLGFQRQ LQEFEKH 137 |
|
| Keyword | Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Lipoprotein; Myristate; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005737 | ; C:cytoplasm | | GO:0005634 | ; C:nucleus | | GO:0004725 | ; F:protein tyrosine phosphatase activity | | GO:0008138 | ; F:protein tyrosine/serine/threonine phosphatase activity | | GO:0000122 | ; P:negative regulation of transcription from RNA polymerase II promoter | | GO:0035335 | ; P:peptidyl-tyrosine dephosphorylation | | GO:0046330 | ; P:positive regulation of JNK cascade | | GO:0042127 | ; P:regulation of cell proliferation | | GO:0007179 | ; P:transforming growth factor beta receptor signaling pathway |
|
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |