EKS-MUM-00486

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00486

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	469.5	6.3E-141	43	305	263

Status

Reviewed

Ensembl Protein

ENSMUSP00000070259

UniProt Accession

Q8C4X2; Q8BM57; Q8C001; Q8K079;

Protein Name

Casein kinase I isoform gamma-3

Protein Synonyms/Alias

CKI-gamma 3;

Gene Name

Csnk1g3

Gene Synonyms/Alias

Csnk1g3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000073563	ENSMUSP00000070259	ENSMUST00000069597

Organism

Mus musculus

Functional Description

Serine/threonine-protein kinase. Casein kinases areoperationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Regulates fast synaptic transmission mediated by glutamate.

Protein Length

424

Protein Sequence
(FASTA)

MDNKKKDKDK SDDRMARPSG RSGHSTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 60

KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 120

PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKAQQV 180

IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 240

YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 300

DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA HQHRDKIQQS 360

KNQVVSSTNG ELNTDDPTAG RSNAPITAPT EVEVMDETNC QKVLNMWCCC FFKRRKRKTI 420

QRHK 424

Nucleotide Sequence
(FASTA)

ATGGATAATA AAAAGAAAGA CAAGGACAAA TCAGATGATA GAATGGCACG GCCCAGTGGT 60

CGGTCAGGGC ACAGCACTCG AGGAACTGGG TCTTCTTCAT CTGGAGTTTT AATGGTTGGA 120

CCTAACTTTA GAGTTGGGAA AAAAATCGGA TGTGGCAATT TTGGAGAATT ACGATTAGGG 180

AAAAATTTAT ACACAAATGA ATATGTGGCG ATTAAACTGG AGCCCATGAA ATCCAGAGCA 240

CCACAGCTGC ATTTGGAATA CAGATTCTAT AAGCAGTTAG GATCTGGAGA TGGTATACCT 300

CAAGTTTACT ATTTTGGCCC TTGTGGTAAA TACAACGCGA TGGTGCTGGA ACTGCTGGGA 360

CCGAGTTTGG AGGATTTGTT TGACCTCTGT GATAGAACAT TTTCTCTTAA AACAGTTCTC 420

ATGATAGCTA TACAGCTGAT TTCTCGTATG GAGTATGTCC ACTCAAAGAA CTTGATATAC 480

AGAGATGTGA AGCCTGAGAA CTTCTTAATA GGACGGCCAG GAAACAAAGC CCAGCAAGTC 540

ATTCATATCA TAGATTTTGG TTTGGCAAAG GAATATATTG ATCCAGAGAC AAAGAAACAT 600

ATACCATACA GAGAACACAA AAGCCTTACC GGAACCGCCA GATACATGAG CATAAACACA 660

CATCTAGGAA AAGAGCAGAG TAGAAGAGAT GATTTAGAAG CCTTAGGCCA CATGTTCATG 720

TACTTCCTGA GAGGCAGTCT TCCTTGGCAA GGCTTAAAGG CTGACACATT AAAAGAGAGG 780

TATCAGAAAA TTGGAGACAC AAAACGAGCC ACACCAATAG AAGTGTTGTG TGAGAACTTC 840

CCAGAAGAAA TGGCAACGTA TCTCCGTTAC GTACGAAGGC TGGATTTTTT TGAAAAGCCA 900

GACTATGATT ACCTAAGAAA GCTTTTTACT GACTTGTTTG ATCGAAAAGG GTATATGTTT 960

GATTATGAAT ATGACTGGAT TGGTAAACAG TTGCCTACTC CAGTAGGTGC AGTTCAGCAA 1020

GACCCTGCTC TGTCATCAAA CAGAGAAGCA CACCAACACA GAGATAAGAT ACAGCAGTCT 1080

AAAAACCAGG TTGTAAGTTC TACAAATGGA GAGCTGAACA CGGATGACCC CACGGCAGGA 1140

CGGTCGAATG CACCCATTAC AGCTCCTACA GAAGTGGAAG TGATGGACGA GACAAACTGC 1200

CAGAAAGTAT TGAATATGTG GTGCTGCTGT TTTTTCAAAC GAAGGAAAAG GAAAACCATA 1260

CAACGTCACA AATGA 1275

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l +g giP+v

Q: 43    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQV  102

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +yfg+++kyn++vl+llGpsledlfdlc+r+fslktvl++a+qlisr+eyvhsk+liyrd

Q: 103   YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRD  162

         ************************************************************

S: 121   ikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasint  176

         +kP+nfl  igr g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sint

Q: 163   VKPENFL--IGRPGNKaqqvIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT  220

         *******..66666666667****************************************

S: 177   hlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegf  236

         hlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t+ievlce+f

Q: 221   HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF  280

         ************************************************************

S: 237   PeefatylkyvrklkfeekPdyeyl  261

         Pee+atyl+yvr+l+f+ekPdy+yl

Q: 281   PEEMATYLRYVRRLDFFEKPDYDYL  305

         ***********************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPMKSRAPQ LHLEYRFYKQ LGSGDGIPQV 60

YYFGPCGKYN AMVLELLGPS LEDLFDLCDR TFSLKTVLMI AIQLISRMEY VHSKNLIYRD 120

VKPENFLIGR PGNKAQQVIH IIDFGLAKEY IDPETKKHIP YREHKSLTGT ARYMSINTHL 180

GKEQSRRDDL EALGHMFMYF LRGSLPWQGL KADTLKERYQ KIGDTKRATP IEVLCENFPE 240

EMATYLRYVR RLDFFEKPDY DYL 263

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

mmu:70425

;

InterPros

IPR022247	; Casein_kinase-1_gamma_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12605	; CK1gamma_C; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013