EKS-MUM-00359

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00359

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	322.3	5.7E-96	411	659	249

Status

Reviewed

Ensembl Protein

ENSMUSP00000097153

UniProt Accession

Q3ULB5; Q3TY26;

Protein Name

Serine/threonine-protein kinase PAK 6

Protein Synonyms/Alias

p21-activated kinase 6; PAK-6;

Gene Name

Pak6

Gene Synonyms/Alias

Pak6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000074923	ENSMUSP00000106477	ENSMUST00000110853
ENSMUSG00000074923	ENSMUSP00000097153	ENSMUST00000099557

Organism

Mus musculus

Functional Description

Serine/threonine protein kinase that plays a role in theregulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity).

Protein Length

682

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT 60

RVQLQPMKTV VRGSSVPTEG YISGLLNDIQ KLSVISSNTL RGRSPTSRRR AQSLGLLGDD 120

QWAADPDMYL QSPQSEHTDP HGLYLSCNGG TPAGHRQVPW PEPQSPQALP NGMAAKAQSL 180

GPAEFQGASQ RCLQQLGACL QSSPPGTSPP MATGRRGVKV AKHSSEEARP QSCLVGSAIG 240

RPGGEGSPSP KNQESSLKHR LFRSMFLSTP ATGAASSSKP VPLPQNKPNS AFRPPQKDSS 300

SNLVAKAQSL PSEQPMGTFS PLTTSDTSSP QKSLRTAPAA GPLPGRSSPA GSPRTRHAQI 360

STSNLYLPQD PTVAKGALGG EDTGIVTHEQ FKAALRMVVD QGDPRLLLDS YVKIGEGSTG 420

IVCLAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY QHLNVVEMYK SYLVGEELWV 480

LMEFLQGGAL TDIISQVRLN EEQIATVCEA VLQALAYLHA QGVIHRDIKS DSILLTLDGR 540

VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI MVIEMVDGEP 600

PYFSDSPVQA MKRLRDSAPP KLKNSYKVSP VLRDFLDRML VREPQERATA QELLDHPFLL 660

QTGLPECLVP LIQLYRKQTS TC 682

Nucleotide Sequence
(FASTA)

ATGTTCCGCA AGAAAAAGAA GAAACGTCCT GAGATATCAG CCCCGCAGAA CTTCCAGCAT 60

CGTGTCCACA CCTCCTTTGA CCCCAAGGAA GGCAAGTTTG TGGGTCTGCC CCCACAATGG 120

CAGAACATTC TGGATACTCT GAGGCGGCCC AAGCCTGTGG TGGATCCTTC TCGAATCACA 180

CGGGTGCAGT TGCAGCCCAT GAAGACAGTG GTACGGGGCA GCTCAGTGCC CACGGAGGGC 240

TACATCTCCG GGCTGCTCAA CGACATTCAG AAGTTGTCAG TTATCAGCTC CAACACCCTG 300

CGTGGACGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGAGATGAT 360

CAGTGGGCTG CTGACCCCGA TATGTACCTC CAAAGCCCCC AGTCGGAGCA CACTGATCCC 420

CATGGCCTCT ACCTCAGCTG CAATGGGGGC ACACCAGCAG GTCACAGGCA GGTGCCCTGG 480

CCAGAACCAC AGAGCCCGCA GGCCCTGCCC AATGGGATGG CTGCCAAGGC GCAGTCACTG 540

GGCCCTGCTG AGTTCCAGGG TGCCTCACAA CGCTGCCTGC AGCAGCTGGG TGCCTGCCTG 600

CAGAGTTCCC CACCCGGTAC CTCACCCCCT ATGGCCACAG GGAGGCGTGG GGTGAAGGTT 660

GCCAAGCATA GCTCCGAAGA GGCCCGGCCT CAGTCCTGCC TGGTGGGCTC CGCCATTGGC 720

AGGCCAGGTG GAGAAGGCAG CCCTAGCCCT AAGAACCAGG AAAGCAGCCT CAAGCACCGG 780

CTCTTCCGAA GCATGTTCCT GTCCACTCCT GCCACAGGCG CGGCAAGCAG CAGCAAGCCG 840

GTCCCTCTGC CACAGAACAA GCCCAATTCT GCTTTCCGAC CACCACAAAA AGACTCCTCT 900

TCAAACCTGG TAGCCAAGGC CCAGTCCTTG CCCTCAGAGC AGCCCATGGG GACCTTCAGT 960

CCTCTGACCA CCTCAGATAC CAGCAGCCCC CAGAAGTCCC TCCGCACAGC TCCAGCCGCT 1020

GGTCCACTTC CAGGCCGGTC TTCTCCAGCA GGCTCCCCCC GTACCCGGCA TGCTCAGATC 1080

AGCACCAGCA ATCTCTACCT GCCCCAGGAC CCCACAGTGG CCAAGGGGGC CCTGGGTGGC 1140

GAAGACACGG GCATTGTGAC CCATGAACAG TTCAAGGCTG CGCTCAGGAT GGTGGTGGAC 1200

CAGGGTGACC CTCGGCTGCT GCTGGACAGC TACGTGAAGA TTGGGGAGGG CTCCACGGGC 1260

ATTGTGTGTC TGGCCCGGGA GAAGCACTCA GGTCGCCAGG TAGCAGTCAA GATGATGGAC 1320

CTCAGGAAGC AGCAACGCAG GGAGCTGCTC TTTAATGAGG TGGTGATCAT GCGTGACTAC 1380

CAGCACCTCA ACGTGGTGGA GATGTACAAG AGTTACCTGG TAGGAGAGGA GCTGTGGGTG 1440

TTGATGGAGT TCCTGCAGGG CGGGGCCCTC ACAGACATCA TCTCCCAAGT CAGACTGAAT 1500

GAGGAGCAGA TTGCCACTGT GTGTGAAGCT GTGCTTCAGG CCTTGGCTTA CCTGCACGCC 1560

CAGGGTGTCA TCCACCGAGA TATCAAGAGT GATTCCATCC TGCTGACCCT TGATGGCAGG 1620

GTGAAGCTCT CAGACTTTGG GTTCTGTGCT CAGATCAGCA AAGATGTTCC CAAGAGAAAG 1680

TCCCTGGTAG GAACTCCATA CTGGATGGCT CCTGAAGTGA TCTCCAGATC CCTGTACGCT 1740

ACTGAGGTGG ATATCTGGTC TCTGGGCATC ATGGTGATTG AGATGGTGGA TGGAGAACCC 1800

CCCTACTTCA GTGACTCCCC AGTGCAAGCC ATGAAGAGGC TGCGGGACAG CGCCCCACCC 1860

AAGCTAAAGA ACTCTTACAA GGTCTCTCCA GTGCTGCGAG ACTTCCTGGA TCGGATGCTG 1920

GTACGGGAAC CCCAAGAGCG AGCCACGGCC CAGGAGCTTC TGGATCACCC GTTTCTGCTG 1980

CAGACGGGGC TGCCTGAGTG TCTGGTGCCT CTGATACAGC TCTACCGCAA GCAGACCTCC 2040

ACCTGCTGA 2049

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++va+k+++l+kq++ e+l++e+ ++++++h n+ve+++

Q: 411   YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYK  470

         679*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ eelw++me+l+gG+l+d+++   + +l+Eeqia++++ vl+aL+ylH+++viHrd

Q: 471   SYLVGEELWVLMEFLQGGALTDIIS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHRD  527

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++Di

Q: 528   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYATEVDI  585

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  ++ ppklk++ k+s+ +++f++++l ++p+

Q: 586   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQ  645

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 646   ERATAQELLDHPFL  659

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY QHLNVVEMYK 60

SYLVGEELWV LMEFLQGGAL TDIISQVRLN EEQIATVCEA VLQALAYLHA QGVIHRDIKS 120

DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI 180

MVIEMVDGEP PYFSDSPVQA MKRLRDSAPP KLKNSYKVSP VLRDFLDRML VREPQERATA 240

QELLDHPFL 249

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mmu:214230

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013