EKS-MUM-00518

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00518

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSKL	307.3	4.3E-91	838	1046	209

Status

Reviewed

Ensembl Protein

ENSMUSP00000061769

UniProt Accession

Q8BLK9; Q3UDY3; Q6PDY4; Q8BMQ5; Q8BX49;

Protein Name

Ribosomal protein S6 kinase delta-1

Protein Synonyms/Alias

S6K-delta-1; 52 kDa ribosomal protein S6 kinase;

Gene Name

Rps6kc1

Gene Synonyms/Alias

Rps6kc1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000089872	ENSMUSP00000124558	ENSMUST00000159066
ENSMUSG00000089872	ENSMUSP00000125010	ENSMUST00000159624
ENSMUSG00000089872	ENSMUSP00000061769	ENSMUST00000061611
ENSMUSG00000089872	ENSMUSP00000124383	ENSMUST00000159367
ENSMUSG00000089872	ENSMUSP00000123733	ENSMUST00000160889

Organism

Mus musculus

Functional Description

May be involved in transmitting sphingosine-1 phosphate(SPP)-mediated signaling into the cell (By similarity).

Protein Length

1056

Protein Sequence
(FASTA)

MTSPWGHSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WRRYSDFKKL 60

HRELWQIHRN AFRHSELFPP FAKGTVFGRF DKTVIEERRQ CAEDLLQFSA NIPALYNSRQ 120

LQDFFKGGVI SDGSELIGPA EAYPDSPANA FPECGTEGFS SDSDLLSLTV DADSLAEVDD 180

GMASRQGSPS RTFGLSLSTD SSAVGAVASD SEPSRVEDRE SRSLFPSSLK PRLGRRDYLE 240

KAGELIKLAL KKEEEDDYEA ASDFYRKGVD LLLEGVQGES SPTRREAVKR RTAEYLMRAE 300

SICSLRAAPQ LHTGPQPPGS LSSRPPWSLR SPAEELKAFR VLGVIDKVLL VMDTRTEQTF 360

ILKGLRKSSE CSRNRKTIIP RCVPNMVCLH TYIISEESVF LVLQRAEGGK LWSYISKFLN 420

RSSQESLDIK EGRPSMPPRV CLQQPSASPQ GGSSFESRGS DTGSMLKALP LKTSLTPSSQ 480

DDSNQEDDGQ PSSPKWLDSG SSSEDECTAG YLTLCNEYGQ EKMDLVSLSE ESVMQPEGDK 540

ADTQAVSSPA SLATGSVSPS THLRVFSGGE DLEAVSSPPT SESLSRSKNS PMEFFRIDSK 600

DSTSELLGLD FGEKLHSLKP EPLKALFTLE DGDSPSQSLD PGESKRESEA QDSVSRGSDD 660

SVPVISFKEA AAEAISGAEE GRPDLLVNLP GELQPTKEAS AMDPKFSQAS AGRLDSKLLE 720

APDVLCLRLS SEQCHGLGPE GPEELSDPTE FCPGGVIPEH DAQADPGVLF EAAVDHRSSP 780

DQFLFSSLRS ESDRLGQVEV VVTAQALQES LFHISSPCSG ANKEHSAYAD TATSEEVLLF 840

TEPTKEEANS LFQRDSEAQE RGVGAGEADK EIHQIFEDLD KRLAASSRFF IPEGCIQRWA 900

AEMVVALDAL HREGIVCRDL NPNNILLNDG GHIQLTYFSR WSEVEDSCDS DAVARMYCAP 960

EVGAVTEETE ACDWWSLGAV LFELLTGKTL VECHPAGINT HTTLNMPGCV SEEARSLIQQ 1020

LLQFNPMERL GAGVAGVEDI KSHPFFTPVD WAELTR 1056

Nucleotide Sequence
(FASTA)

ATGACCTCTC CTTGGGGTCA CAGTGCGGAC CTGGCCCGCT TCTACACTGT CACCGAGCCC 60

CAGCGACACC CCAGGGGCTA CACTGTCTAT AAGGTTACCG CACGGGTTGT TTCACGGAGA 120

AATCCAGAGG ACGTCCAGGA GATAATTGTG TGGAGGAGAT ACAGTGACTT CAAGAAACTG 180

CACAGAGAAT TATGGCAAAT TCACAGGAAT GCATTTCGAC ACTCTGAGCT ATTTCCCCCG 240

TTTGCTAAAG GGACAGTGTT TGGGCGGTTC GACAAGACGG TGATTGAGGA GCGACGGCAG 300

TGTGCTGAGG ACCTGCTGCA GTTCTCTGCC AACATCCCCG CCCTGTACAA CAGCAGGCAG 360

CTCCAGGACT TCTTCAAGGG TGGGGTAATT AGTGATGGCT CTGAGTTAAT TGGCCCTGCT 420

GAAGCTTACC CAGACTCCCC GGCCAACGCC TTTCCTGAGT GCGGTACTGA AGGATTCTCC 480

AGTGACAGTG ACCTTCTGTC CCTCACTGTT GATGCAGACT CTCTTGCCGA GGTAGATGAT 540

GGAATGGCTT CCCGTCAGGG TTCTCCCAGT AGAACCTTTG GTCTGAGTCT GTCTACGGAT 600

TCTTCGGCAG TAGGGGCTGT TGCTTCTGAC AGTGAACCAA GCAGAGTAGA AGACCGGGAA 660

AGCCGCAGCC TCTTCCCCAG CAGCTTAAAG CCAAGGCTTG GCAGGAGAGA TTACCTGGAG 720

AAGGCAGGGG AACTTATCAA ACTGGCCTTA AAGAAGGAGG AGGAAGATGA CTATGAAGCT 780

GCTTCTGACT TTTACAGGAA GGGCGTCGAT CTGCTCCTAG AAGGTGTACA AGGAGAGTCG 840

AGCCCCACGC GTCGGGAGGC TGTGAAGAGA AGGACTGCGG AGTACCTCAT GCGTGCAGAG 900

AGCATCTGTA GCCTCCGGGC CGCGCCTCAG CTCCACACGG GACCACAGCC TCCAGGATCA 960

CTAAGTTCAA GGCCCCCTTG GAGCCTGAGG AGCCCTGCCG AGGAGCTGAA GGCCTTCCGA 1020

GTCCTTGGGG TGATTGACAA GGTTTTACTT GTAATGGATA CAAGGACAGA GCAGACATTC 1080

ATTTTAAAAG GTCTAAGGAA AAGCAGCGAG TGCAGCAGGA ACAGAAAGAC CATCATCCCC 1140

CGCTGTGTGC CTAACATGGT GTGTCTGCAC ACGTACATCA TCTCGGAGGA ATCGGTGTTT 1200

CTCGTGCTGC AGCGCGCCGA AGGTGGAAAA CTCTGGTCGT ATATCAGTAA ATTTCTGAAC 1260

AGAAGCTCTC AGGAAAGCTT GGACATTAAG GAAGGGAGAC CGTCCATGCC TCCTCGAGTG 1320

TGCCTGCAGC AGCCAAGTGC CAGTCCCCAG GGCGGCAGCA GCTTCGAGTC CAGAGGGAGC 1380

GACACGGGGA GCATGCTGAA GGCTCTGCCT CTGAAGACCA GTCTCACCCC GAGTTCTCAA 1440

GACGACAGCA ACCAGGAAGA CGACGGCCAG CCCAGCTCTC CCAAGTGGCT GGATTCGGGC 1500

TCCAGTTCAG AGGATGAGTG CACAGCGGGC TACCTGACGC TGTGCAACGA GTATGGGCAA 1560

GAAAAGATGG ACCTGGTGTC TCTGAGCGAG GAGTCTGTTA TGCAGCCTGA AGGGGACAAG 1620

GCTGACACCC AGGCGGTTAG TTCCCCAGCA TCCCTCGCCA CTGGCAGTGT GAGCCCTAGC 1680

ACCCACCTCA GGGTCTTCTC TGGAGGTGAG GATCTAGAGG CGGTTTCTTC TCCTCCAACA 1740

TCTGAATCCC TCAGTAGGTC AAAAAACAGC CCTATGGAAT TCTTCAGAAT AGACAGTAAA 1800

GACAGCACAA GTGAGCTCCT GGGACTGGAT TTTGGTGAGA AATTACACAG TCTGAAACCA 1860

GAGCCTTTGA AAGCCCTCTT TACCCTTGAA GATGGAGACA GCCCTTCTCA GAGTCTTGAT 1920

CCTGGTGAGA GCAAGAGAGA GAGTGAAGCT CAGGACTCCG TGAGCCGGGG CTCAGATGAT 1980

TCCGTCCCAG TTATCTCATT TAAAGAGGCG GCTGCAGAGG CTATCAGTGG GGCTGAGGAG 2040

GGAAGGCCTG ACCTTCTTGT GAATTTACCT GGGGAACTGC AGCCAACCAA AGAGGCTTCA 2100

GCAATGGACC CTAAGTTTTC ACAGGCCAGT GCAGGCAGGC TGGATAGTAA ACTGCTGGAA 2160

GCCCCGGATG TGTTGTGCCT CAGGCTGAGT TCTGAACAGT GCCATGGTCT GGGACCAGAA 2220

GGCCCAGAGG AACTGAGCGA TCCCACTGAA TTCTGTCCCG GAGGTGTGAT CCCAGAGCAC 2280

GATGCTCAGG CAGATCCCGG GGTGCTATTC GAGGCTGCCG TTGATCACAG GAGCTCCCCA 2340

GACCAGTTTC TGTTTTCCAG CTTGCGTTCC GAGTCTGACA GGCTGGGGCA GGTGGAGGTA 2400

GTGGTCACTG CACAGGCCTT GCAAGAAAGC CTGTTCCACA TTTCTAGTCC CTGCTCAGGT 2460

GCTAATAAAG AACACAGTGC ATACGCCGAC ACTGCCACGT CGGAGGAGGT GTTGCTGTTC 2520

ACAGAACCGA CTAAAGAAGA AGCGAACTCT CTGTTCCAGA GAGACTCGGA GGCCCAGGAG 2580

CGAGGTGTGG GAGCCGGGGA AGCAGACAAG GAAATCCATC AGATCTTTGA GGACCTGGAT 2640

AAACGACTAG CAGCTAGCTC CAGGTTCTTC ATCCCAGAGG GCTGCATTCA GAGATGGGCA 2700

GCGGAAATGG TGGTAGCCCT TGACGCCTTG CACAGAGAGG GGATTGTGTG CCGAGATCTG 2760

AACCCAAACA ACATCTTATT GAATGATGGA GGACACATTC AGCTAACGTA TTTTAGCAGG 2820

TGGAGTGAGG TTGAAGATTC CTGCGACAGC GATGCCGTAG CGAGAATGTA CTGTGCCCCA 2880

GAGGTTGGAG CAGTCACAGA AGAAACTGAA GCCTGTGATT GGTGGAGCCT GGGTGCTGTC 2940

CTCTTCGAAC TTCTCACTGG CAAGACGTTG GTGGAATGCC ACCCAGCCGG AATAAATACC 3000

CACACTACTT TGAACATGCC AGGTTGTGTT TCTGAAGAGG CTCGCTCACT CATCCAACAG 3060

CTCCTGCAGT TCAACCCTAT GGAGCGCCTG GGTGCTGGAG TGGCTGGTGT TGAAGATATC 3120

AAATCTCACC CGTTTTTCAC CCCTGTGGAT TGGGCAGAGT TGACAAGATG A 3171

Domain Profile

S: 159   klefssdkskaprGnrirregqnssps...sskeiklvsedadkslealsrgldkalqsv  215

          l  +  k +a +  +  +e+q+   +   + kei++++ed+dk+l+a+sr

Q: 838   LLFTEPTKEEANSLFQRDSEAQERGVGageADKEIHQIFEDLDKRLAASSR---------  888

         333344444444444555555554433111458999999999999999999.........

S: 216   dkalslrravwslpEelikqWaaelvvaleaLHeegvlirDlnadniLldskGhllltYf  275

                   +++pE++i++Waae+vval+aLH+eg+++rDln++niLl++ Gh++ltYf

Q: 889   ----------FFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYF  938

         ..........9*************************************************

S: 276   grwsevekscrreavdnlysAPEvgaiselteasDwWslGalLyelLtGkalaeahPsgi  335

         +rwseve+sc+++av+++y+APEvga++e+tea+DwWslGa+L+elLtGk+l+e+hP+gi

Q: 939   SRWSEVEDSCDSDAVARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGI  998

         ************************************************************

S: 336   qahtelqlPevvSeeAkdLleeLLqfePalRlGaGeagvdelkaHPFF  383

         ++ht+l++P +vSeeA++L+++LLqf+P++RlGaG+agv+++k+HPFF

Q: 999   NTHTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFF  1046

         ***********************************************9

Domain Sequence
(FASTA)

LLFTEPTKEE ANSLFQRDSE AQERGVGAGE ADKEIHQIFE DLDKRLAASS RFFIPEGCIQ 60

RWAAEMVVAL DALHREGIVC RDLNPNNILL NDGGHIQLTY FSRWSEVEDS CDSDAVARMY 120

CAPEVGAVTE ETEACDWWSL GAVLFELLTG KTLVECHPAG INTHTTLNMP GCVSEEARSL 180

IQQLLQFNPM ERLGAGVAGV EDIKSHPFF 209

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication

KEGG

mmu:320119

;

InterPros

IPR011009	; Kinase-like_dom.
IPR007330	; MIT.
IPR001683	; Phox.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF04212	; MIT; 1.
PF00069	; Pkinase; 1.
PF00787	; PX; 1.

SMARTs

SM00745	; MIT; 1.
SM00312	; PX; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.
PS50195	; PX; 1.

Prints

Created Date

20-Feb-2013