EKS-NOL-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	412.0	1.1E-123	1	276	276

Status

Unreviewed

Ensembl Protein

ENSNLEP00000000288

UniProt Accession

G1QHA1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK1

Gene Synonyms/Alias

MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000000240	ENSNLEP00000000288	ENSNLET00000000307

Organism

Nomascus leucogenys

Functional Description

Protein Length

323

Protein Sequence
(FASTA)

MVCSAYDNVN KVRVAIKKIS PFEHQTYCQR TLREIKILLR FRHENIIGIN DIIRAPTIEQ 60

MKDVYIVQDL METDLYKLLK TQHLSNDHIC YFLYQILRGL KYIHSANVLH RDLKPSNLLL 120

NTTCDLKICD FGLARVADPD HDHTGFLTEY VATRWYRAPE IMLNSKGYTK SIDIWSVGCI 180

LAEMLSNRPI FPGKHYLDQL NHILGILGSP SQEDLNCIIN LKARNYLLSL PHKNKVPWNR 240

LFPNADSKAL DLLDKMLTFN PHKRIEVEQA LAHPYLEQYY DPSDEPIAEA PFKFDMELDD 300

LPKEKLKELI FEETARFQPG YRS 323

Nucleotide Sequence
(FASTA)

ATGGTGTGCT CTGCGTATGA TAATGTCAAC AAAGTTCGAG TAGCCATCAA GAAAATCAGC 60

CCCTTTGAGC ACCAGACCTA CTGCCAGAGA ACCCTGAGGG AGATAAAAAT CTTACTGCGC 120

TTCAGACATG AGAACATCAT TGGAATCAAT GACATTATTC GAGCACCAAC CATCGAGCAA 180

ATGAAAGATG TATATATAGT ACAGGACCTC ATGGAAACAG ATCTTTACAA GCTCTTGAAG 240

ACACAACACC TCAGCAACGA CCATATCTGC TATTTTCTTT ACCAGATCCT CAGAGGGTTA 300

AAATATATCC ATTCAGCTAA CGTTCTGCAC CGTGACCTCA AGCCTTCCAA CCTGCTGCTC 360

AACACCACCT GTGATCTCAA GATCTGTGAC TTTGGCCTGG CCCGTGTTGC AGATCCAGAC 420

CATGATCACA CAGGGTTCCT GACAGAATAT GTGGCCACAC GTTGGTACAG GGCTCCAGAA 480

ATTATGTTGA ATTCCAAGGG CTACACCAAG TCCATTGATA TTTGGTCTGT AGGCTGCATT 540

CTGGCAGAAA TGCTTTCTAA CAGGCCCATC TTTCCAGGGA AGCATTATCT TGACCAGCTG 600

AACCACATTC TGGGTATTCT TGGATCCCCA TCACAAGAAG ACCTGAATTG TATAATAAAT 660

TTAAAAGCTA GGAACTATTT GCTTTCTCTT CCACACAAAA ATAAGGTGCC ATGGAACAGG 720

CTGTTCCCAA ATGCTGACTC CAAAGCTCTG GACTTACTGG ACAAAATGTT GACATTCAAC 780

CCACACAAGA GGATTGAAGT AGAACAGGCT CTGGCCCACC CATATCTGGA GCAGTATTAC 840

GACCCGAGTG ACGAGCCCAT CGCCGAAGCA CCATTCAAGT TTGACATGGA ATTGGATGAC 900

TTGCCTAAGG AAAAGCTCAA AGAACTAATT TTTGAAGAGA CTGCTAGATT CCAGCCAGGA 960

TACAGATCTT AA 972

Domain Profile

S: 14    vvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpeeel  73

         +v+sa+d+ ++ rvaikk+s pf+++t ++rtlRE+k+l +++heNii + d++++ + +

Q: 1     MVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT-I  58

         79*****************9.**********************************999.*

S: 74    eelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlKPsNl  133

         e++kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hsanv+HrDlKPsNl

Q: 59    EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNL  118

         ************************************************************

S: 134   lvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillslkeytkavDiWsvG  191

         l+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++k ytk++DiWsvG

Q: 119   LLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVG  178

         **********************999999********************************

S: 192   CIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkkdf  251

         CIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arny+ slp+k+k ++

Q: 179   CILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPW  238

         ************************************************************

S: 252   eelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++lfp+a+++aldLl+k+L+++p+kRi+ve+aL+hpYl

Q: 239   NRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL  276

         *************************************7

Domain Sequence
(FASTA)

MVCSAYDNVN KVRVAIKKIS PFEHQTYCQR TLREIKILLR FRHENIIGIN DIIRAPTIEQ 60

MKDVYIVQDL METDLYKLLK TQHLSNDHIC YFLYQILRGL KYIHSANVLH RDLKPSNLLL 120

NTTCDLKICD FGLARVADPD HDHTGFLTEY VATRWYRAPE IMLNSKGYTK SIDIWSVGCI 180

LAEMLSNRPI FPGKHYLDQL NHILGILGSP SQEDLNCIIN LKARNYLLSL PHKNKVPWNR 240

LFPNADSKAL DLLDKMLTFN PHKRIEVEQA LAHPYL 276

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0070371	; P:ERK1 and ERK2 cascade
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013