EPS-NOL-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-NOL-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	198.9	1.2E-58	158	412	255

Status

Unreviewed

Ensembl Protein

ENSNLEP00000000304

UniProt Accession

G1QHB7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000000251	ENSNLEP00000000304	ENSNLET00000000325

Organism

Nomascus leucogenys

Functional Description

Protein Length

449

Protein Sequence
(FASTA)

MSSGAPQKSS QMASGAEETP GFLDTLLQDF PAPLSPEDPL PWKAPGTVLS QEEVEGELAE 60

LAMGFLGSRK APPPLAAALA HEAVSQLLQT DLSEFRKLPS EEEEEEEEDD DEEEKAPVTL 120

LDAQSLARSF FNRLWEVAGQ WQKQVPLAAR ASQRQWLVSI HAIRNTRRKM EDRHVSLPSF 180

NQLFGLSDPV DRAYFAVFDG HGGVDAARYA AVHVHTTAAR QPELTTDPAG ALREAFRRTD 240

QMFLRKAKRE RLQSGTTGVC ALIAGATLHV AWLGDSQVIL VQQGQVVKLM EPHRPERQDE 300

KARIEALGGF VSHMDCWRVN GTLAVSRAIG DVFQKPYVSG EADAASRVLT GSEDYLLLAC 360

DGFFDVVPHQ EVVGLVQSHL TRQQGSGLHV AEELVAAARE RGSHDNITVM VVFLRDPQEL 420

LEGGNQGEGD PQAEGRRQDL PSSLPEPET 449

Nucleotide Sequence
(FASTA)

ATGTCCTCTG GAGCCCCACA GAAGAGCAGC CAAATGGCCA GTGGAGCTGA GGAGACCCCG 60

GGCTTCCTGG ACACGCTGCT GCAAGACTTC CCAGCCCCGC TGAGCCCAGA GGACCCTCTG 120

CCATGGAAGG CCCCGGGGAC GGTGCTCAGC CAGGAGGAGG TGGAGGGCGA GCTGGCTGAG 180

CTGGCCATGG GCTTTCTGGG CAGCAGGAAG GCCCCGCCAC CACTTGCCGC TGCTCTGGCC 240

CATGAAGCAG TTTCACAGCT ACTACAGACA GACCTTTCCG AATTCAGGAA GTTGCCCAGT 300

GAGGAGGAAG AGGAGGAGGA GGAGGATGAC GACGAGGAGG AAAAGGCCCC TGTGACCTTG 360

CTGGATGCCC AAAGCCTGGC ACGGAGTTTC TTTAACCGCC TTTGGGAAGT CGCCGGCCAG 420

TGGCAGAAGC AGGTGCCATT GGCTGCCCGG GCCTCGCAGC GGCAGTGGCT GGTCTCCATC 480

CACGCCATCC GGAACACTCG CCGCAAGATG GAGGACCGGC ACGTGTCCCT CCCTTCCTTC 540

AACCAGCTCT TCGGCTTGTC TGACCCCGTG GACCGCGCCT ACTTTGCTGT GTTTGATGGT 600

CACGGAGGCG TGGATGCTGC GAGGTACGCC GCTGTCCACG TGCACACCAC CGCTGCCCGC 660

CAGCCAGAGC TAACCACAGA CCCTGCGGGA GCCCTCAGAG AAGCCTTCCG GCGCACCGAC 720

CAGATGTTTC TCAGGAAAGC CAAGCGAGAG CGGCTGCAGA GCGGCACCAC AGGTGTGTGT 780

GCGCTCATTG CAGGAGCGAC CCTGCACGTC GCCTGGCTCG GGGACTCCCA GGTCATTTTG 840

GTACAGCAGG GACAGGTGGT GAAGCTGATG GAGCCACACA GACCAGAACG GCAGGATGAG 900

AAGGCACGCA TTGAAGCATT GGGTGGCTTT GTGTCTCACA TGGACTGCTG GAGAGTCAAC 960

GGGACCCTGG CCGTCTCCAG AGCCATCGGG GATGTCTTCC AGAAGCCCTA CGTGTCTGGG 1020

GAGGCCGATG CAGCTTCCCG GGTGCTGACA GGCTCCGAGG ACTACCTGCT GCTTGCCTGC 1080

GATGGCTTCT TTGACGTCGT ACCCCACCAG GAAGTTGTTG GCCTCGTCCA GAGCCACCTG 1140

ACCAGGCAGC AGGGCAGCGG GCTGCATGTC GCCGAGGAGC TGGTGGCTGC GGCCCGGGAG 1200

CGGGGCTCCC ACGACAACAT CACGGTCATG GTGGTCTTCC TCAGGGACCC CCAAGAGCTG 1260

CTGGAGGGCG GGAACCAGGG AGAAGGGGAC CCCCAGGCAG AAGGGAGGAG GCAGGACTTG 1320

CCCTCCAGCC TTCCAGAACC TGAGACCTAG 1350

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v++ ++ + r++med++ s p+f +  + +d    a+f+v+DGhgg ++a++++ ++h+

Q: 158   VSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPvdRAYFAVFDGHGGVDAARYAAVHVHTT  217

         6678999******************9988888778*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

          a++ e     +++   al++aF +td+ +  l +++ +  +sG+t v+ali + +l+va

Q: 218   AARQPE----LTTDPAGALREAFRRTDQMF--LRKAKRERLQSGTTGVCALIAGATLHVA  271

         ****77....66777789************..8888889999******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd  180

          +GdS+++L ++g++v+l + H+p+r+dE++Rie+ gg v   d+ Rv+G LavsRa+Gd

Q: 272   WLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGD  331

         ********************************************99**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

         ++ kpyv+ e +  s  lt ++++l La+DG +dvv+ +e+v lv+++l+ ++ +   +a

Q: 332   VFQKPYVSGEADAASRVLTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTrQQGSGLHVA  391

         ************************************************9967778999**

S: 240   kkLvklalargskdnvsaivv  260

         ++Lv+ a++rgs+dn++++vv

Q: 392   EELVAAARERGSHDNITVMVV  412

         *****************9997

Domain Sequence
(FASTA)

VSIHAIRNTR RKMEDRHVSL PSFNQLFGLS DPVDRAYFAV FDGHGGVDAA RYAAVHVHTT 60

AARQPELTTD PAGALREAFR RTDQMFLRKA KRERLQSGTT GVCALIAGAT LHVAWLGDSQ 120

VILVQQGQVV KLMEPHRPER QDEKARIEAL GGFVSHMDCW RVNGTLAVSR AIGDVFQKPY 180

VSGEADAASR VLTGSEDYLL LACDGFFDVV PHQEVVGLVQ SHLTRQQGSG LHVAEELVAA 240

ARERGSHDNI TVMVV 255

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013