EKS-NOL-00369
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00369
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR584.67.1E-176556889334
StatusUnreviewed
Ensembl ProteinENSNLEP00000023676
UniProt AccessionG1QHS0;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000000372ENSNLEP00000023676ENSNLET00000032051
ENSNLEG00000000372ENSNLEP00000000457ENSNLET00000000486
OrganismNomascus leucogenys
Functional Description
Protein Length939
Protein Sequence
(FASTA)
MVSESPEDLG CALRPQSAGT VYEAAAVEVD VSASITLQVL VDAPGNISCL WVFKHSSLNC 60
QPHFDLQNRG VVSMIILKMT ETQAGEYLLF IQSEATNYTI LFTVSIRNTL LYTLRRPYFR 120
KMENQDALVC ISESVPEPIV EWVLCDSQGE SCKEESPAVV KKEEKVLREL FGTDIRCCAR 180
NELGRECTRL FTIDLNQTPQ TTLPQLFLKV GEPLWIRCKA VHVNHGFGLT WELENKALEE 240
GNYFEMSTYS TNRTMIRILF AFVSSVARND TGYYTCSSSK HPSQSALVTI VEKGFINATN 300
SSEDYEIDQY EEFCFSVRFK AYPQIRCTWT FSRKSFPCEQ KGLDDGYSIS KFCNHKHQPG 360
EYIFHAENDD AQFTKMFTLN IRRKPQVLAE ASASQASCSS DGYPLPSWTW KKCSDKSPNC 420
TEEITEGVWN RKANRKVFGQ WVSSSTLNMS EAIKGFLVKC CAYNSLGTSC ETILLNSPGP 480
FPFIQDNISF YATIGVCLLF IVVLTLLICH KYKKQFRYES QLQMIQVTGS SDNEYFYVDF 540
REYEYDLKWE FPRENLEFGK VLGSGAFGKV MNATAYGISK TGVSIQVAVK MLKEKADSSE 600
REALMSELKM MTQLGSHENI VNLLGACTLS GPIYLIFEYC CYGDLLNYLR SKREKFHRTW 660
TEIFKEHNFS FYPTFQSHPN SSMPGSREVQ IHPDSDQISG LHGNSFHSED EIEYENQKRL 720
EEEEDLNVLT FEDLLCFAYQ VAKGMEFLEF KSCVHRDLAA RNVLVTHGKV VKICDFGLAR 780
DIMSDSNYVV RGNARLPVKW MAPESLFEGI YTIKSDVWSY GILLWEIFSL GVNPYPGIPV 840
DANFYKLIRN GFKMDQPFYA TEEIYIIMQS CWAFDSRKRP SFPNLTSFLG CQLADAEEAM 900
YQNVDGRVSE RPHTYQNRPP FGRETDSGPL SPQAQVEDS 939
Nucleotide Sequence
(FASTA)
ATGGTGTCAG AATCCCCAGA GGACCTCGGG TGTGCGTTGA GACCCCAGAG CGCAGGGACA 60
GTGTACGAAG CTGCCGCTGT GGAAGTGGAT GTATCTGCTT CCATCACACT GCAAGTGCTG 120
GTCGACGCCC CAGGGAACAT TTCCTGTCTC TGGGTCTTTA AGCACAGCTC CCTGAATTGC 180
CAGCCACATT TTGATTTACA AAACAGAGGA GTCGTTTCCA TGATCATTTT GAAAATGACA 240
GAAACCCAAG CTGGAGAATA CCTACTTTTT ATTCAGAGTG AAGCTACCAA TTACACAATA 300
TTGTTTACAG TGAGTATAAG AAATACCCTG CTTTACACAT TAAGAAGACC TTACTTTAGA 360
AAAATGGAAA ACCAGGACGC CCTGGTCTGC ATATCTGAGA GCGTTCCAGA GCCGATCGTG 420
GAATGGGTGC TTTGCGATTC ACAGGGGGAA AGCTGTAAAG AAGAAAGTCC AGCTGTTGTT 480
AAAAAGGAGG AAAAAGTGCT TCGTGAGTTA TTTGGGACAG ACATAAGGTG TTGTGCCAGA 540
AATGAACTGG GCAGGGAATG CACCAGGCTG TTCACAATAG ATCTAAATCA AACTCCTCAG 600
ACCACATTGC CACAATTATT TCTTAAAGTA GGAGAACCCT TATGGATAAG GTGCAAAGCT 660
GTTCATGTGA ACCATGGATT TGGGCTCACC TGGGAATTAG AAAACAAAGC ACTCGAGGAG 720
GGCAACTACT TTGAGATGAG TACCTATTCA ACAAACAGAA CTATGATACG GATTCTGTTT 780
GCTTTTGTAT CATCAGTGGC AAGAAACGAC ACCGGATACT ACACTTGTTC CTCTTCAAAG 840
CATCCCAGTC AATCAGCTTT GGTTACCATC GTAGAAAAGG GATTTATAAA TGCTACCAAT 900
TCAAGTGAAG ATTATGAAAT TGACCAATAT GAAGAGTTTT GTTTTTCTGT CAGGTTTAAA 960
GCCTACCCAC AAATCAGATG TACATGGACC TTCTCTCGAA AATCATTTCC TTGTGAGCAA 1020
AAAGGTCTCG ATGACGGATA CAGCATATCC AAGTTTTGCA ATCATAAGCA CCAGCCAGGA 1080
GAATATATAT TCCATGCAGA AAATGATGAT GCCCAATTTA CCAAAATGTT CACGCTGAAT 1140
ATAAGAAGGA AACCTCAAGT GCTCGCAGAA GCATCAGCAA GTCAGGCGTC CTGTTCCTCG 1200
GATGGATACC CGTTACCATC TTGGACCTGG AAGAAGTGTT CAGACAAGTC TCCCAACTGC 1260
ACCGAAGAGA TCACAGAAGG AGTCTGGAAT AGAAAGGCTA ACAGAAAAGT GTTTGGACAG 1320
TGGGTGTCGA GCAGTACTCT AAACATGAGT GAAGCCATAA AAGGGTTCCT GGTCAAGTGC 1380
TGTGCATACA ATTCCCTTGG CACATCTTGT GAGACGATCC TTTTAAACTC TCCAGGCCCT 1440
TTCCCTTTCA TCCAAGACAA CATCTCATTC TATGCAACAA TTGGTGTTTG TCTCCTCTTC 1500
ATTGTCGTTT TAACCCTGCT AATTTGTCAC AAGTACAAAA AGCAATTTAG GTATGAAAGC 1560
CAGCTACAGA TGATACAGGT GACCGGCTCC TCAGATAATG AGTACTTCTA CGTTGATTTC 1620
AGAGAATATG AATATGATCT CAAATGGGAG TTTCCAAGAG AAAATTTAGA GTTTGGGAAG 1680
GTACTAGGAT CAGGTGCTTT TGGAAAAGTG ATGAACGCAA CAGCTTATGG AATTAGCAAA 1740
ACAGGAGTCT CAATCCAGGT TGCCGTCAAA ATGCTGAAAG AAAAAGCAGA CAGCTCTGAA 1800
AGAGAGGCAC TCATGTCAGA ACTCAAGATG ATGACCCAGC TGGGAAGCCA CGAGAATATT 1860
GTGAATCTGC TGGGGGCGTG CACACTGTCA GGACCAATTT ACTTGATTTT TGAATACTGT 1920
TGCTATGGTG ATCTTCTCAA CTATCTAAGA AGTAAAAGAG AAAAATTTCA CAGGACTTGG 1980
ACAGAGATTT TCAAGGAACA CAATTTCAGT TTTTACCCCA CTTTCCAATC ACATCCAAAT 2040
TCCAGCATGC CTGGTTCAAG GGAAGTTCAG ATACACCCGG ACTCGGATCA AATCTCAGGG 2100
CTTCATGGGA ATTCATTTCA CTCTGAAGAT GAAATTGAAT ATGAAAACCA AAAAAGGCTG 2160
GAAGAAGAGG AGGACTTGAA TGTGCTTACA TTTGAAGATC TTCTTTGCTT TGCATATCAA 2220
GTTGCCAAAG GAATGGAATT TCTGGAATTT AAGTCGTGTG TTCACAGAGA CCTGGCCGCC 2280
AGGAACGTGC TTGTCACCCA CGGGAAAGTG GTGAAGATAT GTGACTTTGG ATTGGCTCGA 2340
GATATCATGA GTGATTCCAA CTACGTTGTC AGGGGCAATG CCCGTCTGCC TGTAAAATGG 2400
ATGGCCCCTG AAAGCCTGTT TGAAGGCATC TACACCATTA AGAGTGATGT CTGGTCATAC 2460
GGAATATTGC TGTGGGAAAT CTTCTCACTT GGTGTGAATC CTTACCCTGG CATTCCAGTT 2520
GATGCTAACT TCTACAAACT GATTCGAAAT GGATTTAAAA TGGATCAGCC ATTTTATGCT 2580
ACAGAAGAAA TATACATTAT AATGCAATCT TGCTGGGCTT TTGACTCAAG GAAACGGCCA 2640
TCCTTCCCTA ATTTGACTTC ATTTTTAGGA TGTCAGCTGG CAGATGCAGA AGAAGCGATG 2700
TATCAGAATG TGGATGGTCG TGTTTCGGAA CGTCCTCACA CCTACCAGAA CAGGCCACCT 2760
TTCGGCAGAG AGACGGATTC GGGGCCACTC TCTCCGCAGG CTCAGGTCGA AGATTCATAG 2820
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk++++lG
Q: 556   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLG  615
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 616   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  674
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++++s  + ++++se++ +++++++   +eeed
Q: 675   ------FQSHPNSSMPGSRE-VQIHPDSDQISGLHGNSFHSEDEIEYENQKRL--EEEED  725
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 726   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD  785
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 786   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  845
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 846   KLIRNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL  889
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTQLG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SREVQIHPDS DQISGLHGNS FHSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDIMSD SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIRNGFKMD 300
QPFYATEEIY IIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0030097; P:hemopoiesis
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013