EKS-NOL-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR232.26.2E-6910991214116
StatusUnreviewed
Ensembl ProteinENSNLEP00000000484
UniProt AccessionG1QHT7;
Protein Name
Protein Synonyms/Alias
Gene NameINSR
Gene Synonyms/Alias INSR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000000403ENSNLEP00000000484ENSNLET00000000518
ENSNLEG00000000403ENSNLEP00000000477ENSNLET00000000512
OrganismNomascus leucogenys
Functional Description
Protein Length1306
Protein Sequence
(FASTA)
MRLLTCLASC SFSLLVCPGM DIRNNLTRLH ELENCSVIEG HLQILLMFKT RPEDFRDLSF 60
PKLIMITDYL LLFRVYGLES LKDLFPNLTV IRGSRLFFNY ALVIFEMVHL KELGLYNLMN 120
ITRGSVRIEK NNELCYLATI DWSRILDSVE DNYIVLNKDD NEECGDICPG TAKGKTNCPA 180
TVINGQFVER CWTHSHCQKV CPTICKSHGC TAEGLCCHSE CLGNCSEPDD PTKCVACRNF 240
YLDGRCVETC PPPYYHFQDW RCVNFSFCQD LHHKCKNSRR QGCHQYVIHN NKCIPECPSG 300
YTMNSSNLLC TPCLGPCPKV CHLLEGEKTI DSVTSAQELR GCTVINGSLI INIRGGNNLA 360
AELEANLGLI EEISGYLKIR RSYALVSLSF FRKLRLIRGE TLEIGNYSFY ALDNQNLRQL 420
WDWSKHNLTI TQGKLFFHYN PKLCLSEIHK MEEVSGTKGR QERNDIALKT NGDQASCKSL 480
VPNLFGMRDW FKMVFPWTVI FSCDIRLVTA FLFCLESPYQ NVTEFDGQDA CGSNSWTVVD 540
IDPPLRSTDP KSQNHPGWLM RGLKPWTQYA IFVKTLVTFS DERRTYGAKS DIIYVQTDAT 600
NPSVPLDPIS VSNSSSQIIL KWKPPSDPNG NITHYLVFWE RQAEDSELFE LDYCLKGKQP 660
SLTVSPWYEQ KNTVRLRQKN HLNPGGGARL CLKKKKKKLK TEMETSIEVL LENENVNITY 720
LNLPSRKRRS LGDVGNVTAA VPTVAAFPNT SSTSVPTSPE EHRPFEKVVN KESLVISGLR 780
HFTGYRIELQ ACNQDTPEER CSVAAYVSAR TMPEAKADDI VGPVTHEIFE NNVVHLMWQE 840
PKEPNGLIVL YEVSYRRYGD EELHLCVSRK HFALERGCRL RGLSPGNYSV RVRATSLAGN 900
GSWTEPTYFY VTDYLDVPSN IAKIIIGPLI FVFLFSVVIG SIYLFLRKRQ PDGPLGPLYA 960
SSNPEYLSAS DVFPCSVYVP DEWEVPREKI TLLRELGQGS FGMVYEGNAR DIIKGEAETR 1020
VAVKTVNESA SLRERIEFLN EASVMKGFTC HHVPPSLPHE YPQNPFLLDL ATTQVSADMG 1080
QVNPLGLCER LRACEPFVLS DFGMTRDIYE TDYYRKGGKG LLPVRWMAPE SLKDGVFTTS 1140
SDMWSFGVVL WEITSLAEQP YQGLSNEQVL KFVMDGGYLD QPDNCPERVT DLMRMCWQFN 1200
PKMRPTFLEI VNLLKDDLHP SFPEVSFFHS EENKAPESEE LEMEFEDMEN VPLDRSSHCQ 1260
REEAGGRDGG SSLGFKRSYE EHIPYTHMNG GKKNGRILTL PRSNPS 1306
Nucleotide Sequence
(FASTA)
ATGCGTCTGC TTACCTGTCT TGCTTCCTGT TCATTTTCTC TTCTAGTGTG TCCCGGCATG 60
GATATCCGGA ACAACCTCAC TAGGTTGCAT GAGCTGGAGA ATTGCTCTGT CATCGAAGGA 120
CACTTGCAGA TACTCTTGAT GTTCAAAACG AGGCCCGAAG ATTTCCGAGA CCTCAGTTTC 180
CCCAAACTCA TAATGATCAC TGATTACTTG CTGCTCTTCC GTGTCTATGG GCTCGAGAGC 240
CTGAAGGACC TGTTCCCCAA CCTCACGGTC ATCCGGGGAT CACGACTGTT CTTTAACTAC 300
GCGCTGGTCA TCTTCGAGAT GGTTCACCTC AAGGAACTCG GCCTCTACAA CCTGATGAAC 360
ATCACCCGGG GTTCTGTCCG CATCGAGAAG AACAATGAGC TCTGTTACTT GGCCACTATC 420
GACTGGTCCC GTATCCTGGA TTCTGTGGAG GATAATTACA TCGTATTGAA CAAAGATGAC 480
AACGAGGAGT GTGGAGACAT CTGTCCGGGT ACCGCGAAAG GCAAAACCAA CTGCCCAGCC 540
ACCGTCATCA ACGGGCAGTT TGTCGAACGG TGTTGGACTC ATAGTCACTG CCAGAAAGTT 600
TGCCCGACCA TCTGTAAGTC ACATGGCTGC ACTGCCGAAG GCCTCTGTTG CCACAGCGAG 660
TGCCTGGGCA ACTGTTCTGA GCCCGACGAC CCCACCAAGT GCGTGGCCTG CCGCAACTTC 720
TACCTGGACG GCAGATGTGT GGAGACCTGC CCGCCCCCGT ACTACCACTT CCAGGACTGG 780
CGCTGTGTGA ACTTCAGCTT CTGCCAGGAC CTGCACCACA AATGCAAGAA CTCGCGGAGG 840
CAGGGCTGCC ACCAGTACGT CATTCACAAC AACAAGTGCA TCCCTGAGTG TCCCTCCGGG 900
TACACGATGA ATTCCAGCAA CTTGCTGTGC ACCCCATGCC TGGGTCCCTG TCCCAAGGTG 960
TGCCACCTCC TAGAAGGCGA GAAGACCATC GACTCGGTGA CGTCTGCCCA GGAGCTCCGA 1020
GGATGCACCG TCATCAACGG GAGTCTGATC ATCAACATTC GAGGAGGCAA CAATCTGGCA 1080
GCTGAGCTAG AAGCCAACCT CGGCCTCATT GAAGAAATTT CAGGTTATCT AAAAATCCGC 1140
CGATCCTACG CTCTGGTGTC ACTTTCCTTC TTCCGGAAGT TACGTCTGAT TCGAGGAGAG 1200
ACCTTGGAAA TCGGGAACTA CTCCTTCTAT GCCTTGGACA ACCAGAACCT AAGGCAGCTC 1260
TGGGATTGGA GCAAACACAA CCTCACCATC ACTCAGGGGA AACTCTTCTT CCACTATAAC 1320
CCCAAACTCT GCCTGTCAGA AATCCACAAG ATGGAAGAAG TTTCAGGAAC CAAGGGGCGC 1380
CAGGAGAGAA ATGACATTGC CCTGAAGACC AATGGGGACC AGGCATCCTG TAAGTCACTG 1440
GTCCCCAACC TTTTTGGCAT GAGGGACTGG TTTAAGATGG TTTTTCCATG GACTGTTATT 1500
TTTTCTTGCG ACATAAGATT GGTAACCGCC TTCCTGTTTT GTCTTGAAAG CCCTTATCAG 1560
AATGTGACGG AGTTCGACGG GCAGGATGCG TGTGGTTCCA ACAGCTGGAC GGTGGTAGAC 1620
ATTGATCCGC CCCTGAGGTC CACCGACCCC AAATCACAGA ACCACCCAGG ATGGCTGATG 1680
CGGGGTCTCA AGCCCTGGAC CCAGTATGCC ATCTTTGTGA AGACCCTGGT CACCTTTTCG 1740
GATGAACGCC GGACCTATGG GGCCAAGAGT GACATCATTT ATGTCCAGAC AGATGCCACC 1800
AACCCCTCTG TGCCCCTGGA TCCAATCTCA GTGTCTAACT CATCATCCCA GATTATTCTG 1860
AAGTGGAAGC CCCCCTCAGA CCCCAATGGC AACATCACCC ACTACCTGGT TTTCTGGGAG 1920
AGGCAGGCGG AAGACAGTGA GCTGTTCGAG CTGGATTATT GCCTCAAAGG GAAGCAGCCA 1980
TCTCTTACCG TGTCTCCGTG GTATGAACAA AAGAACACCG TGAGGCTGAG GCAGAAGAAT 2040
CACTTGAACC CGGGAGGCGG AGCGAGACTC TGTCTTAAAA AAAAAAAAAA AAAGTTAAAA 2100
ACAGAAATGG AAACTTCCAT TGAAGTCCTT TTGGAAAATG AAAATGTGAA TATCACATAC 2160
CTTAACTTGC CATCTCGGAA ACGCAGGTCC CTTGGCGATG TTGGGAATGT GACGGCAGCC 2220
GTGCCCACGG TGGCAGCTTT CCCCAACACT TCCTCAACCA GCGTGCCCAC GAGTCCGGAG 2280
GAGCACAGGC CCTTTGAGAA GGTGGTGAAC AAGGAGTCAC TGGTCATCTC CGGCTTGCGA 2340
CACTTCACGG GCTATCGCAT CGAGCTGCAG GCTTGCAACC AAGACACCCC TGAGGAACGG 2400
TGCAGTGTGG CAGCCTACGT CAGTGCCAGG ACCATGCCTG AAGCCAAGGC TGATGACATT 2460
GTCGGCCCTG TGACGCACGA AATCTTTGAG AACAACGTCG TCCACTTGAT GTGGCAGGAG 2520
CCGAAGGAAC CCAATGGTCT GATTGTGCTG TATGAAGTGA GTTATCGGCG ATATGGCGAT 2580
GAGGAGCTGC ATCTCTGCGT CTCCCGCAAG CACTTCGCTC TGGAACGGGG CTGCAGGCTG 2640
CGCGGGCTGT CGCCGGGGAA CTACAGCGTG CGAGTCCGGG CCACCTCCCT CGCGGGCAAC 2700
GGCTCCTGGA CAGAACCCAC CTATTTCTAC GTGACAGACT ATTTAGATGT CCCGTCAAAT 2760
ATTGCAAAAA TTATCATCGG CCCCCTCATC TTTGTCTTTC TCTTCAGTGT TGTGATTGGA 2820
AGTATTTATC TATTCCTGAG AAAGAGGCAG CCAGATGGGC CGCTGGGACC ACTTTACGCT 2880
TCTTCAAATC CCGAGTATCT CAGTGCCAGT GATGTGTTTC CATGCTCTGT GTACGTGCCG 2940
GACGAGTGGG AGGTGCCTCG AGAGAAGATC ACCCTCCTTC GAGAGCTGGG GCAGGGCTCC 3000
TTTGGCATGG TGTATGAGGG CAACGCCAGG GACATCATCA AGGGTGAGGC AGAGACCCGC 3060
GTGGCAGTGA AGACGGTCAA CGAGTCAGCC AGTCTCCGAG AGCGGATTGA GTTCCTCAAT 3120
GAGGCCTCGG TCATGAAGGG CTTCACCTGC CATCATGTGC CCCCTTCACT TCCCCATGAG 3180
TACCCTCAGA ATCCATTCTT ACTGGATTTG GCCACCACCC AGGTGAGCGC AGACATGGGC 3240
CAGGTGAACC CCTTAGGGCT CTGCGAGAGG TTAAGAGCGT GTGAACCTTT TGTGTTGTCA 3300
GACTTTGGAA TGACCAGAGA CATCTATGAA ACGGATTACT ACCGGAAAGG GGGCAAGGGT 3360
CTACTCCCTG TACGGTGGAT GGCGCCGGAG TCCCTGAAGG ATGGGGTCTT TACCACTTCT 3420
TCTGACATGT GGTCCTTTGG CGTGGTCCTT TGGGAAATCA CCAGCTTGGC AGAACAGCCT 3480
TACCAAGGCC TGTCGAATGA ACAGGTGTTG AAATTTGTCA TGGATGGAGG GTATCTGGAT 3540
CAACCTGACA ACTGTCCAGA GAGAGTCACT GACCTCATGC GCATGTGCTG GCAATTCAAC 3600
CCCAAGATGA GGCCAACCTT CCTGGAGATT GTCAACCTGC TCAAGGATGA CCTGCACCCC 3660
AGCTTTCCGG AGGTGTCGTT CTTCCACAGC GAGGAGAACA AGGCTCCCGA GAGTGAGGAG 3720
CTGGAGATGG AGTTTGAGGA CATGGAGAAT GTGCCCCTGG ACCGTTCCTC ACACTGTCAG 3780
AGGGAGGAGG CGGGGGGCCG GGATGGAGGG TCCTCGCTAG GTTTCAAGCG GAGCTACGAG 3840
GAACACATCC CTTACACACA CATGAACGGA GGCAAGAAAA ACGGGCGGAT TCTGACCTTG 3900
CCTCGGTCCA ATCCTTCCTA A 3921
Domain Profile
S: 153   iGdfGmtrdiyetdyyrkggkgllpvrwmspeslkdGvftsksdvwsfGvvlweivtlae  212
         + dfGmtrdiyetdyyrkggkgllpvrwm+peslkdGvft++sd+wsfGvvlwei++lae
Q: 1099  LSDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE  1158
         67**********************************************************
S: 213   qpyqGlsneqvlkfvldggvlekpencpelltelmrlcwqynpklrpsfleivell  268
         qpyqGlsneqvlkfv+dgg+l++p+ncpe++t+lmr+cwq+npk+rp+fleiv+ll
Q: 1159  QPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL  1214
         *****************************************************976
Domain Sequence
(FASTA)
LSDFGMTRDI YETDYYRKGG KGLLPVRWMA PESLKDGVFT TSSDMWSFGV VLWEITSLAE 60
QPYQGLSNEQ VLKFVMDGGY LDQPDNCPER VTDLMRMCWQ FNPKMRPTFL EIVNLL 116
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00014
EKS-BOT-00015
EKS-CAF-00017
EKS-CAP-00016
EKS-DAR-00021
EKS-FEC-00016
EKS-GAA-00025
EKS-GOG-00019
EKS-HOS-00018
EKS-ICT-00017
EKS-LAC-00018
EKS-LOA-00015
EKS-MEG-00014
EKS-MOD-00015
EKS-MUM-00015
EKS-MUP-00018
EKS-MYL-00018
EKS-ORN-00026
EKS-ORA-00016
EKS-ORC-00014
EKS-ORL-00021
EKS-OTG-00016
EKS-PAT-00017
EKS-PES-00017
EKS-POA-00016
EKS-RAN-00017
EKS-TAG-00016
EKS-TAR-00027
EKS-XET-00016
EKS-XIM-00023
Gene Ontology
GO:0005899; C:insulin receptor complex
GO:0005524; F:ATP binding
GO:0005525; F:GTP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0032148; P:activation of protein kinase B activity
GO:0007186; P:G-protein coupled receptor signaling pathway
GO:0003007; P:heart morphogenesis
GO:0008286; P:insulin receptor signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0048639; P:positive regulation of developmental growth
GO:0045740; P:positive regulation of DNA replication
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0045821; P:positive regulation of glycolysis
GO:0043410; P:positive regulation of MAPK cascade
GO:0045840; P:positive regulation of mitosis
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060267; P:positive regulation of respiratory burst
GO:0046777; P:protein autophosphorylation
GO:0045995; P:regulation of embryonic development
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0019087; P:transformation of host cell by virus
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 2.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 2.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 2.
SM00261; FU; 2.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013