EKS-NOL-00419

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00419

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	423.4	4.0E-127	27	312	286

Status

Unreviewed

Ensembl Protein

ENSNLEP00000000724

UniProt Accession

G1QII1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK12

Gene Synonyms/Alias

MAPK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000000606	ENSNLEP00000000724	ENSNLET00000000770

Organism

Nomascus leucogenys

Functional Description

Protein Length

368

Protein Sequence
(FASTA)

MSSPSPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDSRTG AKVAIKKLYR 60

PFQSELFAKR AYYRELRLLK HMRHENVIGL LDVFTPDETL DGFTDFYLVM PFMGTDLGKL 120

MKHEKLGEDR IQFLVYQMLK GLRYIHAAGI IHRDLKPGNL AVNEDCELKI LDFGLARQAD 180

SEMTGYVVTR WYRAPEVILN WMRYTQTVDI WSVGCIMAEM ITGKTLFKGS DHLDQLKEIM 240

KVTGTPPAEF VQRLQSDEAK NYMKGLPELE KKDFASILTN ASPLAVNLLE KMLVLDAEQR 300

VTAAEALAHP YFESLHDTED EPQVQKYDDS FDDVDRTLDE WKRVTYKEVL SFKPPRQLGA 360

RVSKETAL 368

Nucleotide Sequence
(FASTA)

ATGAGCTCTC CGTCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 60

TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTATGGCGCG 120

GTGTGCTCGG CCGTGGACAG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 180

CCCTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACTACC GCGAGCTGCG CCTGCTCAAG 240

CACATGCGCC ACGAGAACGT GATCGGGCTG CTGGACGTAT TCACTCCTGA TGAGACCCTG 300

GATGGCTTCA CAGACTTTTA CCTGGTGATG CCGTTCATGG GCACTGACCT GGGCAAGCTC 360

ATGAAACATG AGAAGCTAGG CGAGGACCGG ATCCAGTTCC TCGTGTACCA GATGCTGAAG 420

GGGCTGAGGT ATATCCACGC TGCCGGCATC ATCCACAGAG ACCTGAAGCC TGGCAACCTG 480

GCTGTGAACG AAGACTGTGA GCTGAAGATC CTGGACTTTG GCCTGGCCAG GCAGGCAGAC 540

AGTGAGATGA CTGGGTACGT GGTGACCCGG TGGTACCGAG CTCCCGAGGT CATCTTGAAT 600

TGGATGCGCT ACACGCAGAC GGTGGACATC TGGTCTGTGG GCTGCATCAT GGCGGAGATG 660

ATCACAGGCA AGACGCTGTT CAAGGGCAGC GACCACCTGG ACCAGCTGAA AGAGATCATG 720

AAGGTGACAG GGACGCCTCC GGCTGAGTTT GTGCAGCGGC TGCAGAGCGA TGAGGCCAAG 780

AACTACATGA AGGGCCTCCC CGAATTGGAG AAGAAGGATT TTGCCTCCAT CCTGACCAAT 840

GCAAGCCCTC TGGCTGTGAA CCTCCTGGAG AAGATGCTGG TGCTGGATGC GGAGCAGCGG 900

GTGACGGCGG CCGAGGCGCT GGCCCATCCC TACTTCGAGT CCCTGCACGA CACGGAAGAT 960

GAGCCCCAGG TCCAGAAGTA TGATGACTCC TTTGACGACG TGGACCGCAC ACTGGATGAA 1020

TGGAAGCGTG TTACTTACAA AGAGGTGCTC AGCTTCAAGC CTCCCCGGCA GCTGGGGGCC 1080

AGGGTCTCCA AGGAGACGGC TCTGTGA 1107

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrt.lRElkllkelkheN  59

         y++l+p+g+Gayg v+savd+rt+ +vaikkl rpfq+e  akr+ +REl+llk+++heN

Q: 27    YRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYRPFQSELFAKRAyYRELRLLKHMRHEN  86

         7899****************************************946*************

S: 60    iiklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylH  119

         +i lldvftp+e+l+ ++d+Ylv+ +m+tdL k++k++kl +++i++l+yq+l+gl+y+H

Q: 87    VIGLLDVFTPDETLDGFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH  146

         ************************************************************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslk  179

         +a++iHrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++l+++

Q: 147   AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWM  202

         ***********************************9....********************

S: 180   eytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearny  239

         +yt++vDiWsvGCI+aE++tgk+lf+g+d++dql++i++v+gtp +ef+++++s+ea+ny

Q: 203   RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY  262

         ************************************************************

S: 240   ikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +k lp+ +kkdf++++++as+ a++Llek+Lvld+++R++++eaL+hpY+

Q: 263   MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYF  312

         *************************************************6

Domain Sequence
(FASTA)

YRDLQPVGSG AYGAVCSAVD SRTGAKVAIK KLYRPFQSEL FAKRAYYREL RLLKHMRHEN 60

VIGLLDVFTP DETLDGFTDF YLVMPFMGTD LGKLMKHEKL GEDRIQFLVY QMLKGLRYIH 120

AAGIIHRDLK PGNLAVNEDC ELKILDFGLA RQADSEMTGY VVTRWYRAPE VILNWMRYTQ 180

TVDIWSVGCI MAEMITGKTL FKGSDHLDQL KEIMKVTGTP PAEFVQRLQS DEAKNYMKGL 240

PELEKKDFAS ILTNASPLAV NLLEKMLVLD AEQRVTAAEA LAHPYF 286

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade
GO:0045445	; P:myoblast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013