EKS-NOL-00255

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00255

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.2	3.4E-136	195	482	288

Status

Unreviewed

Ensembl Protein

ENSNLEP00000000962

UniProt Accession

G1QJ68;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000000817	ENSNLEP00000000962	ENSNLET00000001021

Organism

Nomascus leucogenys

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

MTRALCSALR QALLLLAAAA ELSAGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60

KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TASPNAPKLG PMELAIIITV 120

PVCLLSIAAM LAIWACQGRQ CSYRKKKRPN VEEPLSECNL VNAGKTLKDL IYDVTASGSG 180

SGLPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ 240

TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA 300

SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN 360

PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD 420

MVPSDPSIEE MRKVVCDQKF RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK 480

TISQLCVKED CKA 493

Nucleotide Sequence
(FASTA)

ATGACCCGGG CGCTCTGCTC AGCGCTCCGC CAGGCTCTCC TGCTGCTCGC CGCGGCCGCC 60

GAGCTCTCGG CAGGACTGAA ATGTGTATGT CTTTTGTGTG ATTCTTCAAA CTTTACCTGC 120

CAAACAGAAG GAGCATGTTG GGCATCAGTC ATGCTAACCA ATGGGAAAGA GCAGGTGATC 180

AAATCCTGTG TCTCCCTTCC AGAACTGAAT GCTCAAGTCT TCTGTCACAG TTCCAACAAT 240

GTCACCAAAA CCGAATGCTG CTTCACAGAT TTTTGCAACA ACATAACACT GCACCTTCCA 300

ACAGCATCAC CAAATGCCCC AAAACTTGGA CCCATGGAGC TGGCCATCAT TATTACTGTG 360

CCTGTTTGCC TCCTGTCCAT AGCTGCGATG CTGGCAATAT GGGCATGCCA GGGTCGACAG 420

TGCTCCTACA GGAAGAAAAA GAGACCGAAT GTGGAGGAAC CACTGTCTGA GTGCAATCTG 480

GTAAATGCTG GAAAAACCCT GAAAGATCTG ATTTATGATG TGACCGCCTC TGGATCTGGC 540

TCTGGTCTAC CTCTGTTGGT TCAAAGGACA ATTGCAAGGA CGATTGTGCT TCAGGAAATA 600

GTAGGAAAAG GTAGATTTGG TGAGGTGTGG CATGGAAGAT GGTGTGGGGA AGATGTGGCT 660

GTGAAAATAT TCTCCTCCAG AGATGAAAGG TCTTGGTTTC GTGAGGCAGA AATTTACCAG 720

ACGGTCATGC TGCGACATGA AAACATCCTT GGCTTCATTG CTGCTGACAA CAAAGATAAT 780

GGAACTTGGA CTCAACTTTG GCTGGTATCT GAATATCATG AACAGGGCTC CTTATATGAC 840

TATTTGAATA GAAACATAGT GACCGTGGCT GGAATGATCA AGCTGGCGCT CTCAATTGCT 900

AGTGGTCTGG CACACCTTCA TATGGAGATT GTTGGTACAC AAGGTAAACC TGCTATTGCT 960

CATCGAGACA TAAAATCAAA GAATATCTTA GTGAAAAAGT GTGAAACTTG TGCCATAGCG 1020

GACTTAGGGT TGGCTGTGAA GCATGATTCA ATACTGAACA CTATCGACAT ACCTCAGAAT 1080

CCTAAAGTGG GAACCAAGAG GTATATGGCT CCTGAAATGC TTGATGATAC AATGAATGTG 1140

AATATCTTTG AGTCCTTCAA ACGAGCTGAC ATCTATTCTG TTGGTCTGGT TTACTGGGAA 1200

ATAGCCCGGA GGTGTTCAGT CGGAGGAATT GTTGAGGAGT ACCAATTGCC TTATTATGAC 1260

ATGGTGCCTT CAGATCCCTC GATAGAGGAA ATGAGAAAGG TTGTTTGTGA CCAGAAGTTT 1320

CGACCAAGTA TCCCAAACCA GTGGCAAAGT TGTGAAGCAC TCCGAGTCAT GGGGAGAATA 1380

ATGCGTGAGT GTTGGTATGC CAACGGAGCG GCCCGCCTAA CTGCCCTTCG TATTAAGAAG 1440

ACTATATCTC AACTTTGTGT CAAAGAAGAC TGCAAAGCCT AA 1482

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 195   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  254

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 255   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  314

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 315   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  372

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 373   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  431

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 432   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  482

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013