EKS-NOL-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	362.9	9.6E-109	41	313	273

Status

Unreviewed

Ensembl Protein

ENSNLEP00000001124

UniProt Accession

G1QJM9;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000000955	ENSNLEP00000001124	ENSNLET00000001192

Organism

Nomascus leucogenys

Functional Description

Protein Length

1144

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGDLRL RVRRVLAEGG FAFVYEAQDM 60

GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 240

GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300

EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS AALSRGPPPP VGPSGSGYSG 360

GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM 420

SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AIYNLSPRTY RPSRFHNRVS ECGWAARRAP 480

HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS 540

MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE 600

VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA 660

SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP 720

PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS 780

PPSSSADASR FLHTLDWQEE KEAETGAENA SPKESESALM EDRDESEVSD EGGSPISSEG 840

QEPRANLEPP GPAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA 900

CRAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEAPLLLASP APPLSVQSTP RGGPPAAADP 960

FGPLLLSSGS DSQPCTNPDL FSEFLNSDSV TVPPSFPSAH SAPPPSCSAD FLHLGPLFSP 1020

GGQPAPCGSQ ASWTKSQNPD PFADLGDLSS GLQECSRRPS TWPVRQPPET FTCVGAAGTS 1080

GRPRVTSVLF CKLTSWIPSW GLRSQNGHHA QRQRLLADKS ATSPGRLMAP SGQAAPQSLH 1140

TAKA 1144

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TTCAGTCGGC GCTCGACTTC TTGGCGGGTC CAGGCTCCCT GGGCGGTGCT 60

TCCGGCCGCG ACCAGAGTGA CTTCGTGGGG CAGACGGTGG AACTGGGCGA CCTGCGGCTG 120

CGGGTGCGGC GGGTCCTGGC CGAAGGAGGG TTTGCATTTG TGTATGAAGC TCAAGATATG 180

GGGAGTGGCA GAGAGTATGC ATTAAAGAGG CTATTATCCA ATGAAGAGGA AAAGAACAGA 240

GCCATCATTC AAGAAGTTTG TTTCATGAAA AAGCTTTCCG GCCACCCGAA CATTGTCCAG 300

TTTTGTTCTG CAGCATCTAT AGGAAAAGAG GAGTCGGACA CGGGGCAGGC TGAGTTCCTC 360

TTGCTCACAG AGCTCTGTAA AGGGCAGCTG GTGGAATTTT TGAAGAAAAT GGAATCTCGA 420

GGTCCCCTGT CGTGTGACAC GGTTCTGAAG ATCTTCTACC AGACGTGCCG CGCCGTGCAG 480

CACATGCACC GGCAGAAGCC GCCCATCATC CACAGGGACC TCAAGGTTGA GAACTTGTTG 540

CTTAGTAACC AAGGGACCAT TAAGCTGTGT GACTTTGGCA GTGCCACGAC CATCTCGCAT 600

TACCCCGACT ACAGCTGGAG CGCCCAGAGG CGAGCCCTGG TGGAGGAAGA GATCACAAGG 660

AATACAACAC CAATGTATAG AACGCCAGAA ATCATAGACT TGTATTCCAA CTTCCCGATC 720

GGCGAGAAGC AGGATATCTG GGCCCTGGGC TGCATCTTGT ACCTGCTATG CTTCCGGCAG 780

CACCCTTTTG AGGATGGAGC AAAGCTTCGA ATAGTCAATG GGAAGTACTC GATCCCCCCG 840

CACGACACGC AGTACACAGT CTTCCACAGC CTCATCCGCG CCATGCTGCA GGTGAACCCG 900

GAGGAGCGGC TGTCCATCGC CGAGGTGGTG CACCAGCTGC AGGAGATCGC GGCCGCCCGC 960

AACGTGAACC CCAAGTCTCC CATCACAGAG CTCCTGGAGC AGAATGGAGG CTACGGGAGC 1020

GCCGCGCTGT CCCGAGGGCC ACCCCCTCCC GTGGGCCCCT CTGGCAGTGG CTACAGTGGA 1080

GGCCTGGCCC TGGCGGAGTA CGACCAGCCG TACGGCGGCT TCCTGGACAT TCTGCGGGGT 1140

GGGACAGAGC GGCTCTTCAC CAACCTCAAG GACACCTCCT CCAAGGTCAT ACAGTCCGTC 1200

GCTAATTACG CAAAGGGTGA CCTGGACATA TCTTACATCA CATCCAGAAT TGCAGTGATG 1260

TCGTTCCCAG CAGAAGGTGT GGAGTCAGCG CTCAAAAACA ACATCGAAGA CGTGCGGTTG 1320

TTCCTGGACT CCAAGCACCC AGGGCACTAC GCCATCTACA ACCTGTCCCC GAGGACCTAC 1380

CGGCCCTCCA GGTTCCACAA CCGGGTTTCC GAGTGTGGCT GGGCAGCGCG GCGGGCCCCG 1440

CACCTGCACA CCCTGTACAA CATCTGCAGG AACATGCATG CCTGGCTGCG GCAGGACCAC 1500

AAGAATGTCT GCGTCGTGCA CTGCATGGAC GGGAGAGCCG CGTCTGCTGT GGCCGTCTGC 1560

TCCTTCCTGT GTTTCTGCCG CCTCTTCAGC ACCGCGGAGG CCGCCGTTTA CATGTTCAGC 1620

ATGAAGCGCT GCCCACCAGG CATCTGGCCG TCCCACAAAA GGTACATCGA GTACATGTGT 1680

GACATGGTGG CAGAGGAGCC CATCACACCC CACAGCAAGC CCATCCTGGT GAGGGCCGTG 1740

GTCATGACGC CCGTGCCACT GTTCAGCAAG CAGAGGAGCG GCTGCAGGCC CTTCTGTGAG 1800

GTCTACGTGG GGGACGAGCG TGTGGCCAGC ACCTCCCAGG AGTACGACAA GATGCGGGAT 1860

TTTAAGATTG AGGATGGCAA AGCGGTGATT CCCCTGGGCG TCACAGTGCA AGGAGACGTG 1920

CTCATTGTCA TCTATCATGC CCGGTCCACT CTGGGTGGCC GGCTGCAGGC CAAGATGGCA 1980

TCCATGAAGA TGTTCCAGAT TCAGTTCCAC ACGGGGTTTG TGCCTCGGAA CGCCACCACT 2040

GTGAAATTTG CCAAGTATGA CCTGGATGCG TGTGACATTC AAGAGAAATA CCCGGATTTA 2100

TTTCAAGTGA ACCTAGAAGT GGAGGTGGAG CCCAGGGACA GGCCGAGCCG GGAAGCCCCG 2160

CCATGGGAGA ACTCGAGCAT GAGGGGGCTG AACCCCAAAA TCCTGTTTTC CAGCCGGGAG 2220

GAGCAGCAAG ACATTCTATC TAAGTTTGGG AAGCCGGAGC TTCCCCGGCA GCCCGGCTCC 2280

ACGGCTCAGT ATGATGCTGG GGCAGGGTCC CCGGAAGCCG AACCCACGGA CTCCGACTCA 2340

CCGCCAAGCA GCAGCGCGGA CGCCAGCCGC TTCCTGCACA CGCTGGACTG GCAGGAAGAG 2400

AAAGAGGCAG AGACAGGTGC AGAAAATGCC TCTCCCAAGG AGAGCGAGTC TGCCCTGATG 2460

GAGGACAGAG ACGAGAGTGA GGTGTCAGAC GAAGGGGGCT CCCCGATCTC CAGCGAGGGC 2520

CAGGAGCCCA GGGCCAACCT GGAGCCCCCC GGCCCGGCAG CAGGGCTGGT ACAGCAGGAC 2580

TTGGTTTTTG AGGTGGAGAC GCCGGCTGTG CTGCCGGAGC CTGTGCCACA GGAAGACGGG 2640

GTGGACCTCC TGGGCCTGCA CTCCGAGGTG GGCGCAGGGC CAGCTGTACC CCCACAGGCC 2700

TGCAGGGCCC CCTCCAGCAA CACCGACCTG CTCAGCTGCC TCCTTGGGCC CCCCGAGGCC 2760

GCCTCCCAGG GGCCCCCGGA GGATCTGCTC AGTGAGGCCC CCCTGCTCCT GGCAAGCCCG 2820

GCCCCTCCCC TGAGCGTGCA GAGCACCCCA AGAGGAGGGC CCCCTGCCGC TGCTGACCCC 2880

TTTGGCCCGC TCCTGCTGTC TTCAGGCAGC GACTCCCAGC CCTGCACCAA TCCTGATCTC 2940

TTCAGCGAAT TTCTCAATTC TGACTCTGTG ACCGTCCCAC CATCCTTCCC GTCTGCCCAC 3000

AGCGCTCCGC CCCCGTCCTG CAGCGCCGAC TTCCTGCACC TGGGCCCCCT CTTCTCTCCT 3060

GGAGGTCAGC CGGCCCCTTG TGGCTCTCAG GCCAGCTGGA CCAAGTCTCA GAACCCGGAC 3120

CCATTTGCTG ACCTTGGCGA CCTCAGCTCC GGCCTCCAAG AATGTTCCCG TCGCCCCAGC 3180

ACCTGGCCTG TGCGCCAGCC CCCGGAGACC TTCACATGTG TGGGTGCAGC CGGCACCTCT 3240

GGACGGCCTC GAGTGACCAG TGTTCTATTT TGCAAGCTCA CCAGCTGGAT TCCCTCCTGG 3300

GGGCTTCGTT CCCAAAACGG CCACCACGCC CAAAGGCAGC GGCTCCTGGC AGACAAGTCG 3360

GCCACCAGCC CAGGGCGCCT CATGGCCCCC TCAGGCCAAG CCGCTCCCCA AAGCCTGCAC 3420

ACAGCCAAGG CCTAA 3435

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++vlaeGGfa+vy a+d+ +g++yalKr+l+neee++++i++E+++mkklsgh+niv+

Q: 41    RVRRVLAEGGFAFVYEAQDMGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+ck g+lv++l+k++++g ls++++lki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAV  159

         **877888999****************.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+lls++g+++lcD+GSatt+++ ++   s+q+++ ++eei+

Q: 160   QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDyswSAQRRALVEEEIT  219

         *******************************************999999***********

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE+idlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysiP

Q: 220   RNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIP  279

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

         +++++++ ++sli++ml+v+peeR++ia+v+++l

Q: 280   PHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL  313

         ******************************9986

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDM GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ 120

HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR 180

NTTPMYRTPE IIDLYSNFPI GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP 240

HDTQYTVFHS LIRAMLQVNP EERLSIAEVV HQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013