EKS-NOL-00275
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00275
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR493.98.8E-149720977258
StatusUnreviewed
Ensembl ProteinENSNLEP00000001285
UniProt AccessionG1QK40;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000000989ENSNLEP00000001285ENSNLET00000001361
OrganismNomascus leucogenys
Functional Description
Protein Length1255
Protein Sequence
(FASTA)
MELAALCGWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 60
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG 120
DPLNNTTLVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA 180
LTLIDTNRSR ACQPCSPVCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC 240
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 300
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 360
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLS 420
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NNRLCFVHTV 480
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC 540
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVSCAHY KDPPFCVARC 600
PSGVKPDLSY MPIWKFPDEE GTCQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG 660
ILLVVVLGAV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 720
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 780
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR 840
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 900
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 960
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 1020
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG 1080
AGSDVFDGDL GMGAAKGLQS LPAHDPSPLQ RYSEDPTVPL PSETDGYVTP LTCSLQPEYV 1140
NQPDVRPQPP SPREGPLPPA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLAPR 1200
GGAAPQPHPP PAFSPAFDNL YYWDQDPSER GAPPSTFKGT PTAENPEYLG LDVPV 1255
Nucleotide Sequence
(FASTA)
ATGGAGCTGG CGGCCTTGTG CGGCTGGGGG CTCCTCCTCG CCCTCTTGCC CCCCGGAGCC 60
GCGAGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG 120
ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGCC AGGTGGTGCA GGGAAACCTG 180
GAACTCACCT ACCTGCCCAC CAATGCCAGC CTCTCCTTCC TGCAGGATAT CCAGGAGGTA 240
CAGGGCTACG TGCTCATCGC TCACAACCAA GTGAGGCAGG TCCCACTGCA GAGGCTGCGG 300
ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AACTATGCCC TGGCTGTGCT AGACAATGGA 360
GACCCGCTGA ACAATACCAC CCTTGTCACA GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG 420
CAGCTTCGAA GCCTCACAGA GATCTTGAAA GGAGGGGTCT TGATCCAGCG GAACCCCCAG 480
CTCTGCTACC AGGACACGAT TTTGTGGAAG GATATCTTCC ACAAGAACAA CCAGCTGGCT 540
CTCACACTGA TAGACACCAA CCGCTCTCGG GCCTGTCAGC CCTGTTCTCC GGTGTGTAAG 600
GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG GATTGTCAGA GCCTGACGCG CACTGTCTGT 660
GCTGGTGGCT GTGCCCGCTG CAAGGGGCCA CTGCCCACTG ACTGCTGCCA TGAGCAGTGT 720
GCTGCCGGCT GCACGGGCCC CAAGCACTCT GATTGCCTGG CCTGCCTCCA CTTCAACCAC 780
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACAGA CACCTTTGAG 840
TCCATGCCCA ATCCCGAGGG CCGGTATACA TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC 900
TACAACTACC TTTCTACGGA CGTGGGATCC TGCACCCTCG TTTGCCCCCT GCACAACCAA 960
GAGGTGACAG CAGAGGACGG AACACAGCGG TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA 1020
GTGTGCTATG GTCTGGGCAT GGAGCACTTG CGAGAGGTGA GGGCAGTCAC CAGTGCCAAT 1080
ATCCAGGAGT TTGCTGGCTG CAAGAAGATC TTTGGGAGCC TGGCATTTCT GCCGGAGAGC 1140
TTTGATGGGG ACCCAGCCTC CAACACCGCC CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT 1200
GAGACTCTGG AAGAGATCAC AGGTTACTTA TACATCTCAG CATGGCCAGA CAGCCTGTCT 1260
GACCTCAGCG TCTTCCAGAA CCTGCAAGTA ATCCGGGGAC GAATTCTGCA CAATGGCGCC 1320
TACTCGCTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC GCTGCGGGAA 1380
CTGGGCAGTG GACTGGCCCT CATCCACCAT AACAACCGCC TCTGCTTCGT GCACACGGTG 1440
CCCTGGGACC AGCTCTTCCG GAACCCGCAC CAAGCCCTGC TCCACACTGC CAACCGGCCA 1500
GAGGACGAGT GTGTGGGCGA GGGCCTGGCC TGCCACCAGC TGTGCGCCCG AGGGCACTGC 1560
TGGGGTCCAG GGCCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC 1620
GTGGAGGAAT GCCGAGTACT GCAGGGGCTT CCCAGGGAGT ATGTGAATGC CAGGCACTGT 1680
TTGCCATGCC ACCCCGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGTTT TGGACCGGAG 1740
GCTGACCAGT GTGTGTCCTG TGCCCACTAT AAAGACCCTC CCTTCTGCGT GGCCCGCTGC 1800
CCCAGCGGTG TGAAACCTGA CCTCTCCTAC ATGCCCATCT GGAAGTTTCC AGATGAGGAG 1860
GGCACGTGCC AGCCTTGCCC CATCAACTGC ACCCACTCCT GTGTGGACCT GGATGACAAG 1920
GGCTGCCCCG CTGAGCAGAG AGCCAGCCCT CTGACGTCCA TCATCTCTGC GGTGGTGGGC 1980
ATCCTGCTGG TCGTGGTCTT GGGGGCGGTC TTTGGGATCC TCATCAAGCG ACGACAGCAG 2040
AAGATCCGGA AGTACACGAT GCGGAGGCTG CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG 2100
ACACCTAGCG GAGCGATGCC CAACCAGGCG CAGATGCGGA TCTTGAAAGA GACGGAGCTG 2160
AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT TTTGGCACAG TCTACAAGGG CATCTGGATC 2220
CCTGATGGGG AGAATGTGAA AATTCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCC 2280
CCCAAAGCCA ACAAAGAAAT CTTAGACGAA GCATACGTGA TGGCTGGTGT GGGCTCCCCA 2340
TATGTTTCCC GCCTCCTGGG CATCTGCCTG ACATCCACGG TGCAGCTGGT GACACAGCTT 2400
ATGCCCTATG GCTGCCTCTT AGACCATGTC CGGGAAAACC GCGGACGCCT GGGCTCCCAG 2460
GACCTGCTGA ACTGGTGTAT GCAGATTGCC AAGGGGATGA GCTACCTGGA GGATGTGCGG 2520
CTCGTACACA GGGACTTGGC TGCTCGGAAC GTGCTGGTCA AGAGTCCCAA CCATGTCAAA 2580
ATTACAGACT TCGGGCTGGC TCGGCTGCTG GACATTGACG AGACAGAGTA CCATGCAGAT 2640
GGGGGCAAGG TGCCCATCAA GTGGATGGCA CTGGAGTCCA TTCTCCGCCG GCGGTTCACC 2700
CACCAGAGTG ATGTGTGGAG TTATGGTGTG ACTGTGTGGG AGCTGATGAC TTTTGGGGCC 2760
AAACCTTACG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGCTGGAAAA GGGGGAGCGG 2820
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA ATGTTGGATG 2880
ATTGACTCTG AATGTCGGCC GAGATTCCGG GAGTTGGTGT CTGAATTCTC CCGCATGGCC 2940
AGGGACCCCC AGCGCTTTGT GGTCATCCAG AATGAGGACT TGGGCCCTGC CAGTCCCTTG 3000
GACAGCACCT TCTACCGCTC ACTGCTGGAG GATGATGACA TGGGGGACCT GGTGGATGCT 3060
GAGGAGTATC TGGTACCCCA GCAGGGCTTC TTCTGTCCAG ACCCTGCCCC GGGTGCTGGG 3120
GGCATGGTCC ACCACAGGCA CCGCAGCTCA TCTACCAGGA GTGGCGGTGG GGACCTGACG 3180
CTAGGGCTGG AGCCCTCAGA AGAGGAGGCC CCCAGGTCTC CACTGGCACC CTCCGAAGGG 3240
GCTGGCTCCG ATGTATTTGA TGGTGACCTG GGAATGGGGG CAGCCAAGGG GCTGCAAAGC 3300
CTCCCCGCAC ATGACCCCAG CCCTCTACAG CGGTACAGTG AGGACCCCAC AGTACCCCTG 3360
CCCTCTGAGA CTGACGGCTA CGTTACCCCC CTGACCTGCA GCCTCCAGCC CGAATATGTG 3420
AACCAGCCAG ATGTTCGGCC ACAACCCCCT TCGCCCCGAG AGGGCCCTCT GCCTCCTGCC 3480
CGACCTGCTG GTGCCACTCT GGAAAGGCCC AAGACTCTCT CCCCAGGGAA GAATGGGGTC 3540
GTCAAAGACG TTTTTGCCTT TGGGGGTGCT GTGGAGAACC CCGAGTACTT GGCACCCCGG 3600
GGAGGAGCTG CCCCTCAGCC CCACCCTCCT CCGGCCTTCA GCCCAGCCTT CGACAACCTC 3660
TATTACTGGG ACCAGGACCC ATCAGAGCGG GGGGCTCCAC CCAGCACCTT CAAAGGGACA 3720
CCTACGGCAG AGAACCCAGA GTACCTGGGT CTGGACGTGC CAGTGTGA 3768
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 720   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  779
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vre++++lGsq+llnwc+qiakGmsyle+ 
Q: 780   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV  839
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 840   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  899
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 900   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  959
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 960   MIDSECRPRFRELVSEFS  977
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLGS QDLLNWCMQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVSEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013