EKS-NOL-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	389.6	5.8E-117	599	864	266

Status

Unreviewed

Ensembl Protein

ENSNLEP00000001609

UniProt Accession

H9H9X6;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000001304	ENSNLEP00000001609	ENSNLET00000001701

Organism

Nomascus leucogenys

Functional Description

Protein Length

896

Protein Sequence
(FASTA)

GSELSGVISS ACDKESNMEQ RVIMISKSEY SVHSSLASKV DVEQVVMYCK EKLIRGESEF 60

SFEELRAQKY NQRRKHEQWV NEDRHYMKRK EANAFEEQLL KQKMDELHKK LHQVVETSHE 120

NLPASQERSE VNPACMGPSV GSQQQLRAPC LPVTYQQTSV TMEKNPREAP PVVPPLANAI 180

SAALVSPATS QSIAPPVPLK AQTVTDSMFA VASKDAGCVN KSTHEFKPQS GAEIKEGCET 240

HKVANTSSFH TTPNTSLGMV QATPSKVQPS PTVHTKEALG FIMNMFQAPT LPDISDDKDE 300

WQSLDQNEDA FEAQFQKDVR SSGAWGVNKI ISSLSSAFHV FEDGNKENYG LPQPKNKSTG 360

ARTFGERSVS RLPSKPKEEV PHAEEFLDDS TIWGIRCNKT LAPSPKSPGD FTSAAQLAST 420

PFHKLPAESV HILEDKENVV AKQCTQVTLD SCEENMVVPS RDGKFSPIQE KSPEQAFSSH 480

MYSASLLRLS QPAAGGVLNC EAELGVEACR LTDTDAAIAE DPPDAIAGLQ AEWMQMSSLG 540

NVDAPNFIVG NPWDDKLIFK LLSGLSKPVS SYPNTFEWQC KLPAIKPKTE FQLGSKLVYV 600

HHLLGEGAFA QVYEATQGDL NDAKNKQKFV LKVQKPANPW EFYIGTQLME RLKPSMQHMF 660

MKFYSAHLFQ NGSVLVGELY SYGTLLNAIN LYKNTPEKVM PQGLVISFAM RMLYMIEQVH 720

DCEIIHGDIK PDNFILGNRF LEQDDEDDLS AGLALIDLGQ SIDMKLFPKG TIFTAKCETS 780

GFQCVEMLSN KPWNYQIDYF GVAATVYCML FGTYMKVKNE GGECKPEGLF RRLPHLDMWN 840

EFFHVMLNIP DCHHLPSLDL LRQKLKKVFQ QHYTNKIRAL RNRLIVLLLE CKRSRK 896

Nucleotide Sequence
(FASTA)

GGTTCAGAGC TTTCTGGAGT GATATCTTCA GCTTGTGATA AAGAGTCAAA TATGGAACAA 60

AGAGTGATCA TGATTTCTAA ATCAGAATAT TCTGTGCACT CATCTTTGGC ATCCAAAGTT 120

GATGTTGAGC AGGTTGTTAT GTATTGCAAG GAGAAGCTTA TTCGTGGGGA ATCAGAATTT 180

TCCTTTGAAG AACTGAGAGC CCAGAAATAT AATCAACGGA GAAAGCATGA GCAATGGGTA 240

AATGAAGACA GACATTATAT GAAAAGGAAA GAAGCAAATG CTTTTGAAGA ACAGCTATTA 300

AAACAGAAAA TGGATGAACT TCATAAGAAG TTGCATCAGG TGGTGGAGAC ATCCCATGAG 360

AATCTGCCCG CTTCCCAGGA AAGGTCCGAG GTTAATCCAG CATGTATGGG GCCAAGTGTA 420

GGCTCCCAGC AGCAACTGAG AGCTCCATGT CTTCCAGTCA CCTATCAGCA GACATCAGTG 480

ACCATGGAAA AGAACCCAAG AGAGGCACCT CCTGTTGTTC CTCCTTTGGC AAATGCTATT 540

TCTGCAGCTT TGGTGTCCCC AGCCACCAGC CAGAGCATTG CTCCTCCTGT TCCTTTGAAA 600

GCCCAGACAG TAACAGACTC CATGTTTGCA GTGGCCAGCA AAGATGCTGG ATGTGTGAAT 660

AAGAGTACTC ATGAATTCAA GCCACAGAGT GGAGCAGAGA TCAAAGAAGG GTGTGAAACA 720

CATAAGGTTG CCAACACAAG TTCTTTTCAC ACAACTCCAA ACACATCACT GGGAATGGTT 780

CAGGCAACGC CATCCAAAGT GCAGCCATCA CCCACCGTGC ACACAAAAGA AGCATTAGGT 840

TTCATCATGA ATATGTTTCA GGCTCCTACA CTTCCTGATA TTTCTGATGA CAAAGATGAA 900

TGGCAATCTC TGGATCAAAA TGAAGATGCA TTTGAAGCCC AGTTTCAAAA AGATGTAAGG 960

TCGTCTGGGG CTTGGGGAGT CAATAAGATC ATCTCTTCTT TGTCATCTGC TTTTCATGTG 1020

TTTGAAGATG GAAACAAAGA AAATTATGGA TTACCACAGC CTAAAAATAA ATCCACAGGA 1080

GCCAGGACCT TTGGAGAACG CTCTGTCAGC AGACTTCCTT CAAAACCAAA GGAAGAAGTG 1140

CCTCATGCTG AAGAGTTTTT GGATGATTCA ACCATATGGG GTATTCGCTG CAACAAAACC 1200

CTGGCACCCA GTCCTAAGAG CCCCGGAGAC TTCACATCTG CTGCACAACT TGCGTCTACA 1260

CCATTCCACA AGCTTCCAGC GGAGTCAGTG CACATTTTAG AAGATAAAGA AAATGTGGTA 1320

GCAAAACAAT GTACCCAGGT GACTTTGGAT TCTTGTGAAG AAAACATGGT GGTGCCTTCA 1380

AGGGATGGAA AATTCAGTCC AATTCAAGAG AAAAGCCCAG AACAGGCCTT CTCGTCTCAC 1440

ATGTATTCAG CATCCTTACT CCGTCTGAGC CAGCCTGCTG CAGGTGGGGT ACTTAACTGT 1500

GAGGCAGAAT TGGGCGTTGA GGCTTGCAGA CTTACAGACA CTGACGCTGC CATTGCAGAA 1560

GATCCACCAG ATGCTATTGC TGGGCTCCAA GCAGAATGGA TGCAGATGAG TTCACTTGGG 1620

AATGTTGATG CTCCAAACTT CATTGTTGGG AACCCATGGG ATGATAAGCT GATTTTCAAA 1680

CTTTTATCTG GGCTTTCTAA ACCAGTGAGT TCCTATCCAA ATACTTTTGA ATGGCAATGT 1740

AAACTTCCAG CCATCAAGCC CAAGACTGAA TTTCAATTGG GTTCTAAGCT GGTCTATGTC 1800

CATCACCTTC TTGGAGAAGG AGCCTTTGCC CAGGTGTACG AAGCTACCCA GGGAGATCTG 1860

AATGATGCTA AAAATAAACA GAAATTTGTT TTAAAGGTCC AGAAGCCTGC CAACCCCTGG 1920

GAATTCTACA TTGGGACCCA GTTGATGGAA AGACTAAAGC CATCTATGCA GCACATGTTT 1980

ATGAAGTTCT ATTCTGCCCA CTTATTCCAG AATGGCAGTG TATTAGTAGG AGAGCTCTAC 2040

AGCTATGGAA CATTATTAAA TGCCATTAAC CTCTATAAAA ATACCCCTGA AAAAGTGATG 2100

CCTCAAGGTC TCGTCATCTC TTTTGCTATG AGAATGCTTT ACATGATTGA GCAAGTGCAT 2160

GACTGTGAAA TCATTCATGG AGACATTAAG CCAGACAATT TCATACTTGG AAACAGATTT 2220

TTGGAACAGG ATGACGAAGA TGATTTATCT GCTGGCTTGG CACTGATTGA CCTGGGTCAG 2280

AGCATAGATA TGAAACTTTT TCCAAAAGGA ACTATATTCA CAGCAAAGTG TGAAACATCT 2340

GGTTTTCAGT GTGTTGAGAT GCTCAGCAAC AAACCATGGA ACTACCAGAT TGATTACTTT 2400

GGGGTTGCTG CAACAGTATA TTGCATGCTC TTTGGTACTT ACATGAAAGT GAAAAATGAA 2460

GGAGGAGAGT GTAAGCCTGA AGGTCTTTTT AGAAGGCTTC CTCATTTGGA TATGTGGAAT 2520

GAATTTTTTC ACGTTATGTT GAATATTCCA GATTGTCATC ATCTTCCATC TTTGGATTTG 2580

TTAAGGCAAA AGCTGAAGAA AGTATTTCAA CAACACTATA CTAATAAGAT TAGGGCCCTA 2640

CGTAATAGGC TAATTGTACT GCTCTTAGAA TGTAAGCGTT CACGAAAATA A 2691

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+a++    d+k++++++lKv+kpan+WefYI +ql+eRlk ++++

Q: 599   YVHHLLGEGAFAQVYEATQgdlnDAKNKQKFVLKVQKPANPWEFYIGTQLMERLK-PSMQ  657

         79******************9999*******************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++++++sa+lfq++s+lv e++sygtll++in++k++ +kvm++ lv+++++++l+++e

Q: 658   HMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIE  717

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgka  177

         ++H++eIiHgD+kPdnf+lgnr+ ++ d+d+ ++gl+liD+g+siDmkl+p+gt f++k+

Q: 718   QVHDCEIIHGDIKPDNFILGNRFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKC  777

         ************************************************************

S: 178   ktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkke  237

         +t++f+c+eml++k+w+Yq+D+fg+aa+++++lfg+y++v++egg++k++  ++rl++ +

Q: 778   ETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLD  837

         ************************************************************

S: 238   lwekiferlLNisdastlpsleelveek  265

         +w+++f+++LNi+d+++lpsl+ l++ k

Q: 838   MWNEFFHVMLNIPDCHHLPSLDLLRQ-K  864

         ************************95.4

Domain Sequence
(FASTA)

YVHHLLGEGA FAQVYEATQG DLNDAKNKQK FVLKVQKPAN PWEFYIGTQL MERLKPSMQH 60

MFMKFYSAHL FQNGSVLVGE LYSYGTLLNA INLYKNTPEK VMPQGLVISF AMRMLYMIEQ 120

VHDCEIIHGD IKPDNFILGN RFLEQDDEDD LSAGLALIDL GQSIDMKLFP KGTIFTAKCE 180

TSGFQCVEML SNKPWNYQID YFGVAATVYC MLFGTYMKVK NEGGECKPEG LFRRLPHLDM 240

WNEFFHVMLN IPDCHHLPSL DLLRQK 266

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013