EKS-NOL-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	345.9	1.1E-103	27	277	251

Status

Unreviewed

Ensembl Protein

ENSNLEP00000001652

UniProt Accession

G1QL39;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK1

Gene Synonyms/Alias

SIK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000001409	ENSNLEP00000001652	ENSNLET00000001748

Organism

Nomascus leucogenys

Functional Description

Protein Length

774

Protein Sequence
(FASTA)

MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK 60

TRLDSSNLEK IYREVQLMKL LNHPHIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH 120

LSENEARTKF WQILSAVEYC HDRHIVHRDL KTENLLLDGN MDIKLAFGFG NFYKSGEPLS 180

TWCGSPPYAA PEVFEGKEYE GPQLDIWSLG VVLYVLVCGS LPFDGPNLPT LRQRVLEGRF 240

RIPFFMSQDC ESLIRRMLVV DPARRISIAQ IRQHRWMRAE PCLPGPACPT FSAHSYSSNL 300

GDYDEQVLGI MQSLGVDRQR TVESLQNSSY NHFAAIYYLL LERLKEYRNA QCARPGPARQ 360

PRPRSSDLSG LEVPQEGLST DPFRPALLCP QPQTLVQSVL QAKMDCELQS SLQWPLFFPV 420

DASCSGVFRP RPVSPSSLLD TAISEEARQG PGLEEEQDTL ESLPSSTGRR HTLAEVSTRL 480

SPLTAPCIVV SPSATASPAE GTSSDSCLTF SASKSPAGLS GTPATQGLLG ACSPVRLASP 540

FLGSQSATPV LQAQGGLGGA VLLPVSFQEG RRASDTSLTQ GEPRSSHTYL HLPQGSCVSL 600

EYVCQAPANR ASRGGLSPFH TPAQSPGLHG GAAGSREGWS LLEEVLEQQR LLQLQHHPAA 660

APGCSQAPQP APAPFVIAPC DGPGAAPLPS TLLMSGLPLL PPPLLQTGVS PVASAAQLLD 720

THLHIGASPT TRPAVPSPRL ARLAPGCEPL GLLQGDCEME DLTACPLGTF VLVQ 774

Nucleotide Sequence
(FASTA)

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGCCAGGG CCAGCAGAAG 60

CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCTGTG 120

GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACACAGGTTG CAATAAAAAT AATTGATAAA 180

ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 240

CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAAGA TATGCTTTAC 300

ATCGTCACTG AATTTGCGAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 360

CTGAGTGAGA ACGAGGCGCG GACGAAGTTT TGGCAAATCC TGTCGGCTGT GGAGTACTGT 420

CACGACCGTC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 480

ATGGACATCA AGCTGGCATT TGGATTTGGG AATTTCTACA AGTCAGGAGA GCCTCTGTCC 540

ACGTGGTGTG GGAGCCCCCC GTATGCCGCC CCGGAAGTCT TTGAGGGGAA GGAGTATGAA 600

GGCCCCCAGC TGGACATCTG GAGCCTGGGC GTGGTGCTGT ATGTCCTGGT CTGCGGTTCT 660

CTCCCCTTCG ATGGGCCTAA CCTGCCGACG CTGAGACAGC GGGTGCTGGA GGGCCGCTTC 720

CGCATCCCCT TCTTCATGTC TCAAGACTGT GAGAGCCTGA TCCGCCGTAT GCTGGTGGTG 780

GACCCCGCCA GGCGCATCAG CATCGCCCAG ATCCGGCAGC ACCGGTGGAT GCGGGCTGAG 840

CCCTGCTTGC CGGGACCCGC CTGCCCCACC TTCTCCGCGC ACAGCTACAG CTCCAACCTG 900

GGCGACTACG ATGAGCAGGT GCTGGGTATC ATGCAGAGCC TGGGTGTTGA CCGGCAGAGG 960

ACGGTGGAGT CACTGCAAAA CAGCAGCTAT AACCACTTTG CTGCCATTTA TTACCTCCTC 1020

CTCGAGCGGC TCAAGGAGTA TCGGAATGCC CAGTGTGCCC GCCCTGGGCC TGCCAGGCAG 1080

CCGCGGCCTC GAAGCTCGGA CCTCAGCGGT TTGGAGGTGC CTCAGGAAGG TCTTTCCACC 1140

GACCCTTTCC GACCCGCCTT GCTGTGCCCA CAGCCGCAGA CCTTGGTGCA GTCCGTCCTG 1200

CAGGCCAAGA TGGACTGTGA GCTCCAGAGC TCACTGCAGT GGCCCTTGTT CTTCCCGGTG 1260

GATGCCAGCT GCAGCGGAGT GTTCCGGCCC CGGCCCGTGT CCCCGAGCAG CCTGCTGGAC 1320

ACAGCCATCA GCGAGGAGGC CAGGCAGGGG CCGGGCCTAG AGGAGGAGCA GGACACGCTG 1380

GAGTCCCTGC CCAGCAGCAC GGGACGGAGG CACACCCTGG CCGAGGTCTC CACCCGCCTC 1440

TCCCCACTCA CCGCTCCATG TATAGTCGTC TCCCCCTCCG CCACGGCGAG TCCTGCAGAG 1500

GGAACCAGCT CGGACAGTTG TCTGACCTTC TCTGCGAGCA AAAGCCCTGC GGGGCTCAGT 1560

GGCACCCCGG CCACTCAGGG GCTGTTGGGC GCCTGCTCCC CGGTCAGGCT GGCCTCACCC 1620

TTCCTGGGGT CGCAGTCCGC CACCCCAGTG CTGCAGGCTC AGGGGGGCTT GGGAGGAGCT 1680

GTTCTGCTCC CTGTCAGCTT CCAGGAGGGA CGGCGGGCGT CGGACACCTC ACTGACTCAA 1740

GGTGAGCCGC GCTCCTCCCA CACTTACCTC CACCTTCCTC AGGGATCATG TGTGTCTTTG 1800

GAGTACGTGT GCCAGGCCCC CGCCAATCGG GCCAGCAGGG GCGGCCTGAG CCCCTTCCAC 1860

ACCCCTGCAC AGAGCCCAGG CCTGCATGGC GGCGCAGCCG GCAGCCGGGA GGGCTGGAGC 1920

CTGCTGGAGG AGGTGCTAGA GCAGCAGAGG CTGCTCCAGT TACAGCACCA CCCGGCCGCT 1980

GCACCTGGCT GCTCACAGGC CCCCCAGCCG GCCCCTGCCC CATTTGTGAT CGCCCCCTGT 2040

GATGGCCCTG GGGCTGCCCC GCTCCCCAGC ACCCTCCTCA TGTCGGGGCT CCCGCTGCTG 2100

CCGCCCCCAC TCCTGCAGAC CGGCGTCTCC CCGGTGGCCT CGGCGGCACA GCTCCTGGAC 2160

ACACACCTGC ACATTGGCGC CAGCCCCACC ACCCGCCCCG CTGTGCCCTC ACCACGCCTG 2220

GCCAGGCTGG CCCCAGGTTG TGAGCCCCTG GGGCTGCTGC AGGGGGACTG TGAGATGGAG 2280

GACCTGACGG CCTGCCCCCT AGGCACCTTT GTCCTGGTGC AGTGA 2325

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++++leki+rE++++k l+hp+i

Q: 27    YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHI  86

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++ly+v+e+a++ge+fdy++++g+l+e+ear+ f q++sav+Y+h+++iv

Q: 87    IKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARTKFWQILSAVEYCHDRHIV  146

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld +++ik+a FG++n++k+g+ l+t+cGsppYaaPe+++gk+Yegp++D

Q: 147   HRDLKTENLLLDGNMDIKLA-FGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLD  205

         *******************9.***************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd++nl +l++++l+g+++ip+ +s+++esL+r++Lvvdp++R

Q: 206   IWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARR  265

         ************************************************************

S: 241   atieeilkhewl  252

         ++i +i++h+w+

Q: 266   ISIAQIRQHRWM  277

         ***********8

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RVTKTQVAIK IIDKTRLDSS NLEKIYREVQ LMKLLNHPHI 60

IKLYQVMETK DMLYIVTEFA KNGEMFDYLT SNGHLSENEA RTKFWQILSA VEYCHDRHIV 120

HRDLKTENLL LDGNMDIKLA FGFGNFYKSG EPLSTWCGSP PYAAPEVFEG KEYEGPQLDI 180

WSLGVVLYVL VCGSLPFDGP NLPTLRQRVL EGRFRIPFFM SQDCESLIRR MLVVDPARRI 240

SIAQIRQHRW M 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0072333	; P:anoikis by p53 class mediator
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013