EKS-NOL-00145
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00145
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR512.14.2E-154664969306
StatusUnreviewed
Ensembl ProteinENSNLEP00000002376
UniProt AccessionG1QN60;
Protein Name
Protein Synonyms/Alias
Gene NameLATS2
Gene Synonyms/Alias LATS2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000001952ENSNLEP00000002376ENSNLET00000002505
OrganismNomascus leucogenys
Functional Description
Protein Length1084
Protein Sequence
(FASTA)
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSAQGLPAG PNSDTSLDAK VLGSKDATRQ 60
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA 120
LKQTGSRSIE AALEYISKMG YLDPRNEQIV RVIKQTSPGK GLMPTPVTRR PSFEGTGDSF 180
ASYHQLSGAP YEGPSFGADG PTALEEVPRP YVDYLFPGVG PHGPGHQHQH PPKGYGASVE 240
AAGAHFPLQG AHYGRPHLLV PGEPLGYGVQ RSPSFQSKTP PETGGYASLP AKGQGGPPGA 300
GLAFPPPAAG LYVPHPHHKQ AGPAAHQLHV LGSRSQVFAS DSPPQSLLTP SRNSLNVDLY 360
ELSSTSVQQW PAATLARRDS LQKPGLEAPP RAHAAFRPDC PVPSRTNSFN SHQPRPGAPG 420
KAEPSLPAPN TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP SHPAWVPAPA PAPAPAAEGL 480
DAKEEHALAL GGAGAYPLDV EYGGPDRRCP PPPYPKHLLL RSKSEQYDLD SLCAGMEQSL 540
RAGPSDPEGG DKSRKSAKGD KGGKDKKQIQ TSPVPVRKNS RDEEKRESRI KSYSPYAFKF 600
FMEQHVENVI KTYQQKVNRR LQLEQEMAKA GLCEAEQEQM RKILYQKESN YNRLKRAKMD 660
KSMFVKIKTL GIGAFGEVCL ACKVDTHALY AMKTLRKKDV LNRNQVAHVK AERDILAEAD 720
NEWVVKLYYS FQDKDSLYFV MDYIPGGDMM SLLIRMEVFP EHLARFYIAE LTLAIESVHK 780
MGFIHRDIKP DNILIDLDGH IKLTDFGLCT GFRWTHNSKY YQKGSHVRQD SMEPSDLWDD 840
VSNCRCGDRL KTLEQRARKQ HQRCLAHSLV GTPNYIAPEV LLRKGYTQLC DWWSVGVILF 900
EMLVGQPPFL APTPTETQLK VINWENTLHI PAQVKLSPEA RDLITKLCCS ADHRLGRNGA 960
DDLKAHPFFS TIDFSSDIRK QPAPYVPTIS HPMDTSNFDP VDEESPWNDA SEGSTKAWDT 1020
LTSPSNKHPE HAFYEFTFRR FFDDNGYPFR CPKPSGAEAS QAENSDLETS DLVDQTEGCQ 1080
PVYV 1084
Nucleotide Sequence
(FASTA)
ATGAGGCCAA AGACTTTTCC TGCCACGACT TATTCTGGAA ATAGCCGGCA GCGACTGCAG 60
GAGATTCGTG AGGGGTTAAA GCAGCCATCC AAGTCTTCGG CTCAGGGGCT ACCCGCGGGA 120
CCAAACAGTG ACACTTCCCT GGATGCCAAA GTCCTGGGGA GCAAAGATGC CACCAGGCAG 180
CAGCAGCAGA TGAGAGCCAC CCCGAAGTTC GGACCTTATC AGAAAGCCTT GAGGGAAATC 240
AGATATTCCT TGTTGCCTTT TGCTAATGAA TCGGGCACCT CTGCAGCTGC AGAAGTGAAC 300
CGGCAAATGC TGCAGGAACT GGTGAACGCA GGATGCGACC AGGAGATGGC TGGCCGAGCT 360
CTCAAGCAGA CCGGCAGCAG GAGCATCGAG GCCGCCCTCG AGTACATCAG CAAGATGGGC 420
TACCTGGACC CGAGGAATGA GCAGATCGTG CGGGTCATTA AGCAGACCTC CCCAGGAAAG 480
GGGCTCATGC CAACCCCAGT GACGCGGAGG CCCAGCTTTG AAGGAACCGG CGATTCGTTT 540
GCGTCCTACC ACCAGCTGAG CGGTGCCCCC TATGAGGGCC CAAGCTTCGG CGCCGACGGC 600
CCCACGGCGC TGGAGGAGGT GCCGCGGCCA TACGTGGACT ACCTCTTCCC CGGAGTCGGC 660
CCCCACGGGC CCGGCCACCA GCACCAGCAC CCACCCAAGG GCTACGGTGC CAGCGTAGAG 720
GCAGCAGGGG CACACTTCCC GCTGCAGGGC GCGCACTATG GCCGGCCACA CCTGCTGGTG 780
CCTGGGGAAC CCCTGGGCTA CGGAGTGCAG CGCAGCCCCT CCTTCCAGAG CAAGACGCCG 840
CCGGAGACCG GGGGCTACGC CAGCCTGCCC GCGAAGGGCC AGGGAGGACC GCCAGGTGCC 900
GGCCTCGCTT TCCCACCACC TGCCGCCGGG CTCTACGTGC CGCACCCACA CCACAAGCAG 960
GCCGGCCCCG CGGCCCACCA GCTGCATGTG CTGGGCTCCC GCAGCCAGGT GTTCGCCAGC 1020
GACAGCCCCC CGCAGAGCCT GCTCACTCCC TCGCGGAACA GCCTCAACGT GGACCTGTAT 1080
GAATTGAGCA GCACCTCCGT CCAGCAGTGG CCCGCTGCCA CCCTGGCCCG CCGGGACTCC 1140
CTGCAGAAGC CGGGCCTGGA GGCGCCGCCG CGCGCGCACG CGGCCTTCCG GCCTGACTGC 1200
CCAGTGCCCA GCAGGACCAA CTCCTTCAAC AGCCACCAGC CGCGGCCGGG TGCGCCCGGC 1260
AAGGCCGAGC CCTCCCTGCC CGCCCCCAAC ACCGTGACGG CTGTCACGGC CGCGCACATC 1320
CTGCACCCGG TGAAGAGCGT GCGTGTGCTG AGGCCAGAGC CGCAGACGGC TGTGGGGCCC 1380
TCGCACCCCG CCTGGGTGCC CGCGCCTGCC CCGGCCCCCG CCCCGGCCGC GGAGGGCCTG 1440
GACGCCAAGG AGGAGCATGC CCTGGCGCTG GGCGGCGCAG GCGCCTACCC GCTGGACGTG 1500
GAGTACGGAG GCCCAGACCG GAGGTGCCCG CCTCCGCCCT ACCCGAAGCA CCTGCTGCTG 1560
CGCAGCAAGT CCGAGCAGTA CGACCTGGAC AGCCTGTGCG CGGGCATGGA GCAGAGCCTC 1620
CGTGCGGGCC CCAGCGATCC CGAGGGCGGT GACAAGAGCC GTAAAAGCGC CAAGGGGGAC 1680
AAAGGCGGAA AGGATAAAAA GCAGATTCAG ACCTCTCCCG TTCCCGTCCG CAAAAACAGC 1740
AGAGACGAAG AGAAGAGAGA GTCACGCATC AAGAGCTACT CGCCATACGC CTTTAAGTTC 1800
TTCATGGAGC AGCATGTGGA GAATGTCATC AAAACCTACC AGCAGAAGGT TAACCGGAGG 1860
CTGCAGCTGG AGCAAGAAAT GGCCAAAGCT GGACTCTGTG AAGCTGAGCA GGAGCAGATG 1920
CGGAAGATCC TCTACCAGAA AGAGTCTAAT TACAACAGGT TAAAGAGGGC CAAGATGGAC 1980
AAGTCTATGT TTGTCAAAAT CAAAACCCTG GGGATCGGTG CCTTTGGAGA AGTGTGCCTT 2040
GCTTGTAAGG TGGACACTCA CGCCCTGTAC GCCATGAAGA CCCTAAGGAA AAAGGATGTC 2100
CTGAACCGGA ATCAGGTGGC CCACGTCAAG GCCGAGAGGG ACATCCTGGC CGAGGCAGAC 2160
AATGAGTGGG TGGTCAAACT CTACTACTCC TTCCAAGACA AAGACAGCCT GTACTTTGTG 2220
ATGGACTACA TCCCTGGTGG GGACATGATG AGCCTGCTGA TCCGGATGGA GGTCTTCCCC 2280
GAGCACCTGG CCCGGTTCTA CATCGCAGAG CTGACTTTGG CCATTGAGAG TGTCCACAAG 2340
ATGGGCTTCA TCCACCGAGA CATCAAGCCT GATAACATTT TGATAGATCT GGATGGTCAC 2400
ATTAAACTCA CAGATTTCGG CCTCTGCACT GGGTTCAGGT GGACTCACAA TTCCAAATAT 2460
TACCAGAAAG GGAGCCATGT CAGACAGGAC AGCATGGAGC CCAGCGACCT CTGGGACGAT 2520
GTGTCTAACT GTCGGTGTGG GGACAGGCTG AAGACCCTAG AGCAGAGGGC GCGGAAGCAG 2580
CACCAGAGGT GCCTGGCACA TTCACTGGTG GGGACTCCAA ACTACATCGC ACCCGAGGTG 2640
CTCCTCCGCA AAGGGTACAC TCAGCTCTGT GACTGGTGGA GTGTTGGAGT GATTCTCTTC 2700
GAGATGCTGG TGGGGCAGCC GCCCTTTTTG GCACCTACTC CCACAGAAAC CCAGCTGAAG 2760
GTGATCAACT GGGAGAACAC GCTCCACATT CCAGCCCAGG TGAAGCTGAG CCCTGAGGCC 2820
AGGGACCTCA TCACGAAGCT GTGCTGCTCC GCAGACCACC GCCTGGGGCG GAATGGGGCG 2880
GATGACCTGA AGGCCCACCC CTTCTTCAGC ACCATTGACT TCTCCAGTGA CATCCGGAAG 2940
CAGCCAGCCC CCTACGTTCC CACCATCAGC CACCCCATGG ACACCTCGAA TTTCGACCCT 3000
GTAGATGAAG AAAGCCCTTG GAACGATGCC AGCGAAGGTA GCACCAAGGC CTGGGACACA 3060
CTCACCTCGC CCAGTAACAA GCATCCAGAG CACGCATTTT ACGAGTTCAC CTTCCGAAGG 3120
TTCTTTGATG ACAATGGCTA CCCCTTTCGA TGCCCAAAGC CTTCAGGAGC AGAAGCTTCA 3180
CAGGCTGAGA ACTCAGATTT AGAAACCTCT GATCTGGTGG ATCAGACTGA AGGCTGCCAG 3240
CCTGTGTACG TGTAG 3255
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         f k+k++g+GafGev+l++k dt+++ya+k+lrkkd+l++nqvahvkaerdilaead+ew
Q: 664   FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW  723
         889*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vvklyysfqdk++ly+vm+y+PGGd+m+lli++e+++e+larfyiael+la+esvhk+Gf
Q: 724   VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF  783
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173
         ihrd+kPdn+lid +GhikltdfGlctG+++th+s+yy++ +++++d++e s+       
Q: 784   IHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDlwddvsn  843
         **************************************************9999******
S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228
              +lk+le+r++k+++r+la+slvGtp+yiapevl++kgy++lcdwWs+Gvil+eml
Q: 844   crcgdRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML  903
         ************************************************************
S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288
         vG+pPfla tp+et+ kvinw++tl++p++v+ls+ea+dli++l+++a++rlg++G+d++
Q: 904   VGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDL  963
         ************************************************************
S: 289   kkhpff  294
         k+hpff
Q: 964   KAHPFF  969
         *****9
Domain Sequence
(FASTA)
FVKIKTLGIG AFGEVCLACK VDTHALYAMK TLRKKDVLNR NQVAHVKAER DILAEADNEW 60
VVKLYYSFQD KDSLYFVMDY IPGGDMMSLL IRMEVFPEHL ARFYIAELTL AIESVHKMGF 120
IHRDIKPDNI LIDLDGHIKL TDFGLCTGFR WTHNSKYYQK GSHVRQDSME PSDLWDDVSN 180
CRCGDRLKTL EQRARKQHQR CLAHSLVGTP NYIAPEVLLR KGYTQLCDWW SVGVILFEML 240
VGQPPFLAPT PTETQLKVIN WENTLHIPAQ VKLSPEARDL ITKLCCSADH RLGRNGADDL 300
KAHPFF 306
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00145
EKS-ANC-00145
EKS-BOT-00152
EKS-CAJ-00156
EKS-CAF-00160
EKS-CAP-00152
EKS-DAR-00440
EKS-DIO-00082
EKS-EQC-00150
EKS-GAG-00130
EKS-GAA-00181
EKS-HOS-00158
EKS-ICT-00146
EKS-LAC-00163
EKS-LOA-00152
EKS-MAM-00151
EKS-MEG-00120
EKS-MOD-00152
EKS-MUM-00157
EKS-MUP-00157
EKS-MYL-00162
EKS-OCP-00100
EKS-ORN-00189
EKS-ORC-00143
EKS-ORL-00177
EKS-OTG-00158
EKS-PAT-00143
EKS-POA-00149
EKS-SAH-00147
EKS-SOA-00027
EKS-TAG-00180
EKS-TAR-00198
EKS-TEN-00191
EKS-XET-00141
EKS-XIM-00183
Gene Ontology
GO:0005634; C:nucleus
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0035329; P:hippo signaling cascade
GO:0009755; P:hormone-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR009060; UBA-like.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013