EKS-NOL-00427
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00427
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK362.31.5E-1084279276
StatusUnreviewed
Ensembl ProteinENSNLEP00000002370
UniProt AccessionG1QN54;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK3
Gene Synonyms/Alias MAPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000001983ENSNLEP00000002370ENSNLET00000002499
ENSNLEG00000001983ENSNLEP00000002372ENSNLET00000002501
OrganismNomascus leucogenys
Functional Description
Protein Length328
Protein Sequence
(FASTA)
GPLSSAYDHV RKTRVAIKKI SPFEHQTYCQ RTLREIQILL RFRHENVIGI RDILRASTLE 60
AMRDVYIVQD LMETDLYKLL KSQQLSNDHI CYFLYQILRG LKYIHSANVL HRDLKPSNLL 120
INTTCDLKIC DFGLARIADP EHDHTGFLTE YVATRWYRAP EIMLNSKGYT KSIDIWSVGC 180
ILAEMLSNRP IFPGKHYLDQ LNHILGEGGP AAEWGMISFS EVRFLKSPHQ GHRHVWAPPV 240
FPVTSDSCPS IALDLLDRML TFNPNKRITV EEALAHPYLE QYYDPTDEPV AEEPFTFAME 300
LDDLPKERLK ELIFQETARF QPGVLETP 328
Nucleotide Sequence
(FASTA)
GGTCCCCTCA GCTCGGCCTA TGACCACGTG CGCAAGACTC GCGTGGCCAT CAAGAAGATC 60
AGTCCCTTCG AGCATCAGAC CTACTGCCAG CGCACGCTCC GGGAGATCCA GATCCTGCTG 120
CGCTTCCGCC ATGAGAATGT CATCGGCATC CGAGACATTC TGCGGGCGTC CACCCTGGAA 180
GCCATGAGGG ATGTCTACAT TGTGCAGGAC CTGATGGAGA CTGACCTGTA CAAGTTGCTG 240
AAAAGCCAGC AGCTGAGCAA TGACCATATC TGCTACTTCC TCTACCAGAT CCTGCGGGGC 300
CTCAAGTACA TCCACTCCGC CAATGTGCTC CACCGAGATC TAAAGCCCTC CAACCTGCTC 360
ATCAACACCA CCTGCGACCT TAAGATTTGC GATTTCGGCC TGGCCCGGAT TGCCGATCCT 420
GAGCATGACC ACACCGGCTT CCTGACGGAG TATGTGGCTA CGCGCTGGTA CCGGGCCCCA 480
GAGATCATGC TGAACTCCAA GGGCTATACC AAGTCCATCG ACATCTGGTC TGTGGGCTGC 540
ATTCTAGCTG AGATGCTCTC TAACCGGCCC ATCTTCCCTG GCAAGCACTA CCTGGATCAG 600
CTCAACCACA TTCTGGGTGA GGGAGGCCCG GCTGCTGAGT GGGGGATGAT TAGCTTTTCC 660
GAGGTGAGAT TTCTCAAGAG TCCACATCAG GGACACCGCC ATGTGTGGGC TCCTCCAGTC 720
TTCCCTGTGA CCTCTGACTC CTGCCCTTCC ATAGCCCTTG ATCTGCTGGA CCGGATGTTA 780
ACCTTTAACC CCAATAAACG GATCACAGTG GAGGAAGCGC TGGCTCACCC CTACCTGGAG 840
CAGTACTATG ACCCGACGGA TGAGCCAGTG GCCGAGGAGC CCTTCACCTT CGCCATGGAG 900
CTGGATGACC TACCTAAGGA GCGGCTGAAG GAGCTCATCT TCCAGGAGAC AGCACGCTTC 960
CAGCCCGGAG TGCTGGAGAC CCCCTAG 987
Domain Profile
S: 16    vsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpeeelee  75
          sa+d+ +++rvaikk+s pf+++t ++rtlRE+++l +++heN+i + d++++++ le+
Q: 4     SSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAST-LEA  61
         6899*************9.***********************************99.***
S: 76    lkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlKPsNllv  135
         ++dvY+v++lmetdL+k++ksq+ls++hi ++lyqilrglky+Hsanv+HrDlKPsNll+
Q: 62    MRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI  121
         ************************************************************
S: 136   nedcelkildFGlarsadkekekk..lteyvatrwYraPeillslkeytkavDiWsvGCI  193
         n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++k ytk++DiWsvGCI
Q: 122   NTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI  181
         ********************99999***********************************
S: 194   laElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkkdfe.  252
         laE+l+++p+fpgk+++dql++il   g + e  + ++++    +++ks ++ +++ ++ 
Q: 182   LAEMLSNRPIFPGKHYLDQLNHILGEGGPAAEWGMISFSEV---RFLKSPHQGHRHVWAp  238
         ************************99998888777777764...5666666555555541
S: 253   elfpk....aseealdLleklLvldpdkRisveeaLehpYl  289
          +fp       + aldLl+++L+++p+kRi+veeaL+hpYl
Q: 239   PVFPVtsdsCPSIALDLLDRMLTFNPNKRITVEEALAHPYL  279
         45555444456679**************************7
Domain Sequence
(FASTA)
SSAYDHVRKT RVAIKKISPF EHQTYCQRTL REIQILLRFR HENVIGIRDI LRASTLEAMR 60
DVYIVQDLME TDLYKLLKSQ QLSNDHICYF LYQILRGLKY IHSANVLHRD LKPSNLLINT 120
TCDLKICDFG LARIADPEHD HTGFLTEYVA TRWYRAPEIM LNSKGYTKSI DIWSVGCILA 180
EMLSNRPIFP GKHYLDQLNH ILGEGGPAAE WGMISFSEVR FLKSPHQGHR HVWAPPVFPV 240
TSDSCPSIAL DLLDRMLTFN PNKRITVEEA LAHPYL 276
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>
EKS-ORA-00408
EKS-OTG-00478
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0071260; P:cellular response to mechanical stimulus
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0000165; P:MAPK cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008349; MAPK_ERK1/2.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01770; ERK1ERK2MAPK.
Created Date20-Feb-2013