EKS-NOL-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	3.4E-97	1077	1341	265

Status

Unreviewed

Ensembl Protein

ENSNLEP00000002707

UniProt Accession

G1QP41;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000002250	ENSNLEP00000002707	ENSNLET00000002853

Organism

Nomascus leucogenys

Functional Description

Protein Length

1346

Protein Sequence
(FASTA)

MENKETLKGL HKMDDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV KPIPVKGDGS 60

EMNHLAAESP GEAQASAASP ASKGRRSPSP GNSPSGRTMK SESPGVRRKR VSPVPFQSGR 120

ITPPRRAPSP DGFSPYSPEE TNRRVNKVMR ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG 180

PQNCSCARGT FCIHLLFVML RVFQLEPSDP MLWRKTLKNF EVESLFQKYH SRRSSRIKAP 240

SRNTIQKFVS RMSNSHTLSS SSTSTSSSEN SIKDEEEQMC PICLLGMLDE ESLTVCEDGC 300

RNKLHHHCMS IWAEECRRNR EPLICPLCRS KWRSHDFYSH ELSSPVDSPS SLRATQQQTV 360

QQQSLAASQR RNQESNFNLT HYGTQQIPPA YKDLAEPWIQ VFGMELVGCL FSRNWNVREM 420

ALRRLSHDVS GALLLANGES TGNSGGSSGS SPSGGATSGS SQTSISGDVV EACCNVLSMV 480

CADPVYKVYV AALKTLRAML VYTPCHSLAE RIKLQRLLQP VVDTILVKCA DANSRTSQLS 540

ISTLLELCKG QAGELAVGRE ILKAGSIGIG GVDYVLNCIL GNQTESNNWQ ELLGRLCLID 600

RLLLEFPAEF YPHIVSTDVS QAEPVEIRYK KLLSLLTFAL QSIDNPHSMV GKLSRRIYLS 660

SARMVTTVPH VFSKLLEMLS VSSSTHFTRM RRRLMAIADE VEIAEAIQLG VEDTLDGQQD 720

SFLQTSVPNN CPETTENSSP ECTIHLEKTG KGLCATKLSA SSEDISERLA SISVGPSSST 780

TTTEQPKPMV QTKGRPHSQC LNSSPLSHHS QLMFPALSTP SSSAPSVPAG TATDVSKHRL 840

QGFVPCRIPS ASPQTQRKFS LQFHRNCPEN KDSDKLSPVF TQSRPLPSSN IHRPKPSRPT 900

PGNTSKQGEP SKNSMTLDLN SSSKCDDSFG CSSNSSNAVI PSDETVFTPV EEKCRLDVNT 960

ELNSSIEDLL EASMPSSDTT VTFKSEVAVL SPEKAENDDT YKDDVNHNQK CKEKMEAEEE 1020

EALAIAMAMS ASQDALPIVP QLQVENGEDI IIIQQDTPET LPGHTKAKQP YREDTEWLKG 1080

QQIGLGAFSS CYQAQDVGTG TLMAVKQVTY VRNTSSEQEE VVEALREEIR MMSHLNHPNI 1140

IRMLGATCEK SNYNLFIEWM AGGSVAHLLS KYGAFKESVV INYTEQLLRG LSYLHENQII 1200

HRDVKGANLL IDSTGQRLRI ADFGAAARLA SKGTGAGEFQ GQLLGTIAFM APEVLRGQQY 1260

GRSCDVWSVG CAIIEMACAK PPWNAEKHSN HLALIFKIAS ATTAPSIPSH LSPGLRDVAL 1320

RCLELQPQDR PPSRELLKHP VFRTTW 1346

Nucleotide Sequence
(FASTA)

ATGGAGAATA AAGAGACTCT CAAAGGGTTG CACAAGATGG ACGATCGTCC AGAGGAACGA 60

ATGATCAGGG AAAAACTGAA GGCAACCTGT ATGCCAGCCT GGAAGCACGA ATGGTTGGAA 120

AGGAGAAATA GGCGAGGGCC TGTGGTGGTA AAACCAATCC CAGTTAAAGG AGATGGATCT 180

GAAATGAATC ACTTAGCAGC TGAGTCTCCA GGAGAGGCCC AGGCAAGTGC GGCTTCACCA 240

GCTTCCAAAG GCCGACGCAG TCCTTCTCCT GGCAACTCCC CATCAGGTCG CACAATGAAA 300

TCAGAATCTC CAGGAGTAAG GAGAAAAAGA GTTTCCCCAG TGCCTTTTCA GAGTGGCAGA 360

ATCACACCAC CCCGAAGAGC CCCTTCACCA GATGGCTTCT CACCATATAG CCCTGAGGAA 420

ACAAACCGCC GTGTTAACAA AGTGATGCGA GCCAGACTAT ACTTACTGCA GCAGATAGGG 480

CCCAACTCTT TCCTGATTGG AGGAGACAGC CCAGACAATA AATACCGGGT GTTTATTGGG 540

CCTCAGAACT GCAGCTGTGC ACGTGGAACA TTCTGTATTC ATCTGCTATT TGTGATGCTC 600

CGGGTATTTC AACTAGAACC TTCAGACCCA ATGTTATGGA GAAAAACTTT AAAGAATTTT 660

GAGGTTGAGA GTTTGTTCCA GAAATATCAC AGTAGGCGTA GCTCAAGGAT CAAAGCTCCA 720

TCTCGTAACA CCATCCAGAA GTTTGTTTCA CGCATGTCAA ATTCTCATAC ATTGTCATCA 780

TCTAGTACTT CTACATCTAG TTCAGAAAAC AGCATAAAGG ATGAAGAGGA ACAGATGTGT 840

CCTATTTGCT TATTGGGCAT GCTTGATGAA GAAAGTCTTA CAGTGTGTGA AGACGGCTGC 900

AGGAACAAGC TGCACCACCA CTGCATGTCA ATTTGGGCAG AAGAGTGTAG AAGAAATAGA 960

GAACCTTTAA TATGTCCCCT TTGTAGATCT AAGTGGAGAT CTCATGATTT CTACAGCCAC 1020

GAGTTGTCAA GTCCTGTGGA TTCCCCTTCT TCCCTCAGAG CCACACAGCA GCAAACCGTA 1080

CAGCAGCAGT CTTTGGCTGC ATCACAAAGA AGGAATCAAG AGAGCAATTT TAACCTTACT 1140

CATTATGGAA CTCAGCAGAT CCCTCCTGCT TACAAAGATT TAGCTGAGCC ATGGATTCAG 1200

GTGTTTGGAA TGGAACTCGT TGGCTGCTTA TTTTCTAGAA ACTGGAATGT GAGAGAGATG 1260

GCCCTCAGGC GTCTTTCCCA TGATGTCAGT GGGGCCCTGC TGTTGGCAAA TGGGGAGAGC 1320

ACTGGAAATT CTGGGGGCAG CAGTGGAAGC AGCCCGAGTG GGGGAGCCAC CAGTGGGTCT 1380

TCCCAGACCA GTATCTCAGG AGATGTGGTG GAGGCATGCT GCAACGTTCT GTCAATGGTC 1440

TGTGCTGACC CTGTCTACAA AGTGTACGTT GCTGCTTTAA AAACACTGAG AGCCATGCTG 1500

GTATATACTC CTTGCCACAG TTTAGCGGAA AGAATCAAAC TTCAGAGACT TCTCCAGCCA 1560

GTTGTAGACA CCATCCTAGT CAAATGTGCA GATGCCAATA GCCGCACAAG TCAGCTGTCC 1620

ATATCAACAC TGTTGGAACT ATGCAAAGGC CAAGCAGGAG AGTTGGCAGT TGGCAGAGAA 1680

ATACTAAAAG CTGGATCCAT TGGTATTGGT GGTGTTGATT ATGTCTTAAA TTGTATTCTT 1740

GGAAACCAAA CTGAATCAAA CAATTGGCAA GAACTTCTTG GCCGCCTTTG TCTTATAGAT 1800

AGACTGTTGT TGGAATTTCC TGCTGAATTT TATCCTCATA TTGTCAGTAC TGATGTTTCA 1860

CAAGCTGAGC CTGTTGAAAT CAGGTATAAG AAGCTGCTGT CCCTCTTAAC CTTTGCTTTG 1920

CAGTCCATTG ATAATCCCCA CTCAATGGTT GGCAAACTTT CCAGAAGGAT CTACTTGAGT 1980

TCTGCAAGAA TGGTTACTAC AGTACCCCAT GTGTTTTCAA AACTGTTAGA AATGCTGAGT 2040

GTTTCCAGTT CCACTCACTT CACCAGGATG CGTCGCCGTT TGATGGCTAT TGCAGATGAG 2100

GTGGAAATTG CTGAAGCCAT CCAGTTGGGC GTAGAAGACA CTTTGGATGG TCAACAGGAC 2160

AGCTTCTTGC AGACATCTGT TCCCAACAAC TGTCCGGAAA CCACAGAGAA CAGTTCCCCT 2220

GAGTGCACAA TCCATTTAGA GAAAACTGGA AAAGGATTAT GTGCTACAAA ATTGAGTGCC 2280

AGTTCAGAGG ACATTTCTGA GAGACTGGCC AGCATTTCAG TAGGACCTTC TAGTTCAACA 2340

ACAACAACAG AGCAACCAAA GCCAATGGTT CAAACAAAAG GCAGACCCCA CAGTCAGTGT 2400

TTGAACTCCT CTCCTTTATC TCATCATTCC CAATTAATGT TTCCAGCCTT GTCAACCCCT 2460

TCTTCTTCGG CCCCATCTGT ACCAGCTGGC ACTGCAACAG ATGTCTCTAA GCATAGACTT 2520

CAGGGATTCG TTCCCTGCAG AATACCTTCT GCATCTCCTC AAACACAGCG CAAGTTTTCT 2580

CTACAATTCC ACAGAAACTG TCCTGAAAAC AAAGACTCAG ATAAACTTTC CCCAGTCTTT 2640

ACTCAGTCAA GACCCTTGCC CTCCAGTAAC ATACACAGGC CAAAGCCATC TCGACCTACC 2700

CCAGGTAATA CAAGTAAACA GGGAGAGCCC TCAAAAAATA GCATGACACT TGATCTGAAC 2760

AGTAGTTCCA AATGTGATGA CAGCTTTGGC TGTAGCAGCA ATAGTAGTAA TGCAGTTATA 2820

CCCAGTGACG AGACAGTGTT CACCCCAGTA GAGGAGAAAT GCAGATTAGA TGTCAATACA 2880

GAGCTCAACT CCAGTATTGA GGACCTTCTT GAAGCATCTA TGCCTTCAAG TGATACAACA 2940

GTAACTTTTA AGTCAGAAGT TGCTGTTCTG TCTCCTGAAA AGGCTGAAAA TGATGATACT 3000

TACAAAGATG ATGTGAATCA TAATCAAAAG TGCAAAGAAA AGATGGAAGC TGAAGAGGAA 3060

GAAGCTTTAG CAATTGCCAT GGCAATGTCA GCATCTCAGG ATGCCCTCCC CATAGTTCCT 3120

CAGCTGCAGG TTGAAAATGG AGAAGATATC ATCATTATTC AACAGGATAC ACCAGAGACT 3180

CTACCAGGAC ATACCAAAGC AAAACAGCCG TATAGAGAAG ACACTGAATG GCTGAAAGGT 3240

CAACAGATAG GCCTTGGAGC ATTTTCTTCT TGTTACCAGG CTCAAGATGT GGGAACTGGA 3300

ACTTTAATGG CTGTTAAACA GGTGACTTAT GTCAGAAACA CATCTTCTGA GCAAGAAGAA 3360

GTAGTAGAAG CATTAAGAGA AGAGATAAGA ATGATGAGCC ATCTGAATCA TCCAAACATC 3420

ATTAGGATGT TGGGAGCCAC GTGTGAGAAG AGCAATTATA ATCTCTTCAT TGAATGGATG 3480

GCAGGGGGAT CGGTGGCTCA TTTGCTGAGT AAATATGGAG CCTTCAAAGA ATCAGTAGTT 3540

ATTAACTACA CTGAACAGTT ACTTCGTGGC CTTTCGTATC TCCATGAAAA CCAAATCATT 3600

CACAGAGATG TCAAAGGTGC CAATTTGCTA ATTGACAGCA CTGGTCAGAG ACTAAGAATT 3660

GCAGATTTTG GAGCTGCAGC CAGGTTGGCA TCAAAAGGAA CTGGTGCAGG AGAGTTTCAG 3720

GGACAATTAC TGGGGACAAT TGCATTTATG GCACCTGAGG TACTAAGAGG TCAACAGTAT 3780

GGAAGGAGCT GTGATGTATG GAGTGTTGGC TGTGCTATTA TAGAAATGGC TTGTGCAAAA 3840

CCACCATGGA ATGCAGAAAA ACACTCCAAT CATCTTGCTT TGATATTTAA GATTGCTAGT 3900

GCAACTACTG CTCCATCGAT CCCTTCACAT TTGTCTCCTG GTTTACGAGA TGTGGCTCTT 3960

CGTTGTTTAG AACTTCAACC TCAGGACAGA CCTCCATCAA GAGAGCTACT GAAGCATCCA 4020

GTCTTTCGTA CTACGTGGTA G 4041

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1077  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1136

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1137  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1196

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1197  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1256

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1257  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1314

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1315  LRDVALRCLELQPQDRPPSRELLKHPV  1341

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0071260	; P:cellular response to mechanical stimulus

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013