EKS-NOL-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	435.5	6.5E-131	220	486	267

Status

Unreviewed

Ensembl Protein

ENSNLEP00000002824

UniProt Accession

G1QPF8;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK2

Gene Synonyms/Alias

CHEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000002348	ENSNLEP00000002824	ENSNLET00000002971

Organism

Nomascus leucogenys

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL 60

SSLETVSTQE LYSIPEDQEP EDQEPEEPAP APWARLWALQ DGFANLECVN DNYWFGRDKS 120

CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR 180

RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER 240

KTCKKVAIKI ISKRKFAIGS ARETDPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV 300

LDLMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE 360

DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC 420

LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA 480

LRHPWLQ 487

Nucleotide Sequence
(FASTA)

ATGTCTCGGG AGTCGGATGT TGAGGCTCAG CAGTCCCATG GCAGCAGTGC CTGTTCACAG 60

CCCCATGGCA GTGTTACCCA GTCCCAAGGC TCCTCCTCAC AATCCCAGGG CATATCCAGC 120

TCCTCTACCA GCACGATGCC AAACTCCAGC CAGTCCTCTC ACTCCAGCTC TGGGACACTG 180

AGCTCCTTAG AGACAGTGTC CACTCAGGAA CTCTATTCTA TTCCTGAGGA CCAAGAACCT 240

GAGGACCAAG AACCTGAGGA GCCTGCCCCT GCCCCCTGGG CTCGATTATG GGCCCTTCAG 300

GATGGATTTG CCAATCTTGA ATGTGTGAAT GACAACTACT GGTTTGGGAG GGACAAAAGC 360

TGTGAATATT GCTTTGATGA ACCACTGCTG AAAAGAACAG ATAAATACCG GACGTATAGC 420

AAGAAACACT TTCGGATTTT CAGGGAAGTG GGTCCTAAAA ACTCTTACAT TGCATACATA 480

GAAGATCACA GTGGCAATGG AACCTTTGTA AATACAGAGC TTGTAGGGAA AGGAAAACGC 540

CGTCCTTTGA ATAACAATTC TGAAATTGCA CTTTCACTAA GCAGAAATAA AGTTTTTGTC 600

TTTTTTGATC TGACAGTAGA TGATCAGTCA GTTTATCCTA AGGCATTAAG AGATGAATAC 660

ATCATGTCAA AAACTCTTGG AAGTGGTGCC TGTGGAGAGG TAAAGCTGGC TTTCGAGAGG 720

AAAACATGTA AGAAAGTAGC CATAAAGATC ATCAGCAAAA GGAAGTTTGC TATTGGTTCA 780

GCAAGAGAGA CAGACCCAGC TCTCAATGTT GAAACAGAAA TAGAAATTTT GAAAAAGCTA 840

AATCATCCTT GCATCATCAA GATTAAAAAC TTTTTTGATG CAGAAGATTA TTATATTGTC 900

CTGGATCTGA TGGAAGGGGG AGAACTGTTT GACAAAGTGG TGGGGAATAA ACGCCTAAAA 960

GAAGCTACCT GCAAGCTCTA TTTTTACCAG ATGCTCTTGG CTGTGCAGTA CCTTCATGAA 1020

AACGGTATTA TACACCGTGA CTTAAAGCCA GAGAATGTTT TACTGTCATC TCAAGAAGAG 1080

GACTGTCTTA TAAAGATTAC TGATTTTGGG CACTCCAAGA TTTTGGGAGA GACCTCTCTC 1140

ATGAGAACCT TATGTGGAAC CCCCACCTAC TTGGCTCCTG AAGTTCTTGT TTCTGTTGGG 1200

ACTGCTGGGT ATAACCGTGC TGTGGACTGC TGGAGTTTAG GAGTTATTCT TTTTATCTGC 1260

CTTAGTGGAT ATCCACCTTT CTCTGAGCAT AGGACTCAAG TGTCACTGAA GGATCAGATC 1320

ACCAGTGGAA AATACAACTT CATTCCTGAA GTCTGGGCAG AAGTCTCAGA GAAAGCTCTG 1380

GACCTTGTCA AGAAGTTGTT GGTAGTGGAT CCAAAGGCAC GTTTTACGAC AGAAGAAGCC 1440

TTAAGACACC CGTGGCTTCA G 1461

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59

         yi+sk+lG+Ga+g+vkla+e+kt+kkva+ki+skrk +i+s+re++ a +ve+e+eilkk

Q: 220   YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKfAIGSARETDPALNVETEIEILKK  279

         89*********************************999**********************

S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119

         l+hP+i+k+k++f++e++ y+vl+l+egGel+dkvv +k+lke+++kl+f+q+l av+yl

Q: 280   LNHPCIIKIKNFFDAEDY-YIVLDLMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL  338

         *****************9.*****************************************

S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179

         he+giihrDlkPen+Lls++eed+l+kitDfG++k+lge+slm+tlCGtp+y+aPevlv+

Q: 339   HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS  398

         ************************************************************

S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239

          g+a+y+++vD+WslGv+lf++lsGypPfse++tqvslk+qi++gky+fi+e+w+++se+

Q: 399   VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK  458

         ************************************************************

S: 240   akdlikklLvvdPeerlsieealnhpWl  267

         a+dl+kklLvvdP++r+++eeal+hpWl

Q: 459   ALDLVKKLLVVDPKARFTTEEALRHPWL  486

         ***************************8

Domain Sequence
(FASTA)

YIMSKTLGSG ACGEVKLAFE RKTCKKVAIK IISKRKFAIG SARETDPALN VETEIEILKK 60

LNHPCIIKIK NFFDAEDYYI VLDLMEGGEL FDKVVGNKRL KEATCKLYFY QMLLAVQYLH 120

ENGIIHRDLK PENVLLSSQE EDCLIKITDF GHSKILGETS LMRTLCGTPT YLAPEVLVSV 180

GTAGYNRAVD CWSLGVILFI CLSGYPPFSE HRTQVSLKDQ ITSGKYNFIP EVWAEVSEKA 240

LDLVKKLLVV DPKARFTTEE ALRHPWL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0044257	; P:cellular protein catabolic process
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006302	; P:double-strand break repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0046777	; P:protein autophosphorylation
GO:0042176	; P:regulation of protein catabolic process
GO:0072428	; P:signal transduction involved in intra-S DNA damage checkpoint
GO:0090307	; P:spindle assembly involved in mitosis

KEGG

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013