EKS-NOL-00350

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00350

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	287.0	1.3E-85	1	222	222

Status

Unreviewed

Ensembl Protein

ENSNLEP00000002980

UniProt Accession

G1QPW4;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100595740

Gene Synonyms/Alias

LOC100595740;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000002463	ENSNLEP00000002980	ENSNLET00000003132

Organism

Nomascus leucogenys

Functional Description

Protein Length

860

Protein Sequence
(FASTA)

MLRHPNIIEL RGVCLQQPHL CLVLEFARGG ALNRALAAAN AAPDPRAPGP RRARRIPPHV 60

LVNWAVQIAR GMLYLHEEAF VPILHRDLKS SNILLLEKIE HDDICNKTLK ITDFGLAREW 120

HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 180

AVNKLTLPIP STCPEPFAKL MKECWEQDPH IRPSFALILE QLTAIEGAVM TEMPQESFHS 240

MQDDWKLEIQ QMFDELRTKE KELRSREEEL TRAALQQKSQ EELLKRREQQ LAEREIDVLE 300

RELNILIFQL NQEKPKVKKR KGKFKRSRLK FKDGHRISLP SDFQHKITVQ ASPNLDKRRS 360

LNSSSSSPPS SPTMMPRLRA IQLTSDESNK TWGRNTVFRQ EEFEDIKRNF KKKGCTWGPN 420

SIQMKERTDC KERIRPLSDG NSPWSTILIK NQKTMPLASL FVDQPGSCEE PKLSPDGLEH 480

RKPKQIKLAS QAYIDLPLGK DAQRENPAEA ESWEEATSAN AATVSTEMTP MNSLGRSSQR 540

KKTESALYGC TVLLASVALG LDLRELDKAQ AAEEPLPKEE KKKREGIFQR ASKSRRSASP 600

PTRLLSTGGE ASSPPSLPLT SVLGILSTPS LSTKCLLQMD SEDPLAGSTP VTCDSEMLTL 660

DFCPTAPGSG HEPALMPRLD TDRSVSRNLP SSFLEQTCGS VPYWASSKHR PSHHRRTMSD 720

GNPTPTGATI ISATGASALP LCPSLYPHSH LPREVSPKKH STVHMMLQPR PASLRSRSDP 780

PQAYPQTAVS QLAQTACVVG RPGPHPTQFL AAKERTKSHV PSLLDADVEG QSRDYTVPLC 840

RMRSKTSRPS IYELEKEFLS 860

Nucleotide Sequence
(FASTA)

ATGCTGCGGC ACCCCAACAT CATCGAGCTG CGCGGCGTGT GCCTGCAGCA GCCGCACCTC 60

TGCCTGGTGC TGGAGTTCGC CCGCGGCGGA GCGCTCAACC GTGCGCTGGC CGCCGCCAAC 120

GCGGCCCCGG ACCCGCGCGC GCCCGGCCCC CGCCGCGCGC GCCGCATCCC TCCGCACGTG 180

CTGGTCAACT GGGCCGTGCA GATAGCGCGG GGCATGCTCT ACCTGCATGA GGAGGCCTTC 240

GTGCCCATCC TGCACCGGGA CCTCAAGTCC AGCAACATTT TGCTACTTGA GAAGATAGAA 300

CATGATGACA TCTGCAATAA AACTTTGAAG ATTACAGATT TTGGGTTGGC GAGGGAATGG 360

CACAGGACCA CCAAAATGAG CGCAGCAGGC ACCTATGCCT GGATGGCCCC CGAAGTGATC 420

AAGTCTTCCT TGTTTTCTAA GGGAAGCGAC ATTTGGAGCT ATGGAGTGCT GCTGTGGGAA 480

CTGCTCACGG GAGAAGTCCC CTATCGGGGC ATTGATGGCC TCGCCGTGGC TTATGGGGTA 540

GCAGTCAATA AACTCACTTT GCCCATTCCA TCCACCTGCC CTGAGCCGTT TGCCAAGCTC 600

ATGAAAGAAT GCTGGGAACA AGACCCTCAT ATTCGTCCAT CGTTTGCCTT AATTCTTGAA 660

CAGTTGACTG CTATTGAAGG GGCAGTGATG ACTGAGATGC CTCAAGAATC TTTTCATTCC 720

ATGCAAGATG ACTGGAAACT AGAAATTCAA CAAATGTTTG ATGAGTTGAG AACAAAGGAA 780

AAGGAGCTGC GATCCCGGGA AGAGGAGCTG ACTCGGGCAG CTCTGCAGCA GAAGTCTCAG 840

GAGGAGCTGC TAAAGCGGCG GGAGCAGCAG CTGGCAGAGC GCGAGATCGA CGTGCTGGAG 900

CGGGAACTTA ACATTCTGAT ATTCCAGCTA AACCAGGAGA AGCCCAAGGT AAAGAAGAGG 960

AAGGGGAAGT TTAAGAGAAG TCGTTTAAAG TTCAAAGATG GACATCGAAT CAGTTTACCT 1020

TCAGATTTCC AGCACAAGAT AACTGTGCAG GCCTCTCCCA ACTTGGACAA ACGGCGGAGC 1080

CTGAACAGCA GCAGTTCCAG TCCCCCGAGC AGCCCCACAA TGATGCCCCG ACTCCGAGCC 1140

ATACAGTTGA CTTCAGATGA AAGCAATAAA ACTTGGGGAA GGAACACAGT CTTTCGACAA 1200

GAAGAATTTG AGGACATAAA AAGGAATTTT AAGAAAAAAG GTTGTACCTG GGGACCAAAT 1260

TCCATTCAAA TGAAAGAAAG AACAGATTGC AAAGAAAGGA TAAGACCTCT CTCCGATGGC 1320

AACAGTCCTT GGTCAACTAT CTTAATAAAA AATCAGAAAA CCATGCCCTT GGCTTCATTG 1380

TTTGTGGACC AGCCAGGGTC CTGTGAAGAG CCAAAACTTT CCCCTGATGG ATTAGAACAC 1440

AGAAAACCAA AACAAATAAA ATTGGCTAGT CAGGCCTACA TTGATCTACC TCTTGGGAAA 1500

GATGCTCAGA GAGAGAATCC TGCAGAAGCT GAAAGCTGGG AGGAGGCAAC CTCTGCGAAT 1560

GCTGCCACAG TCTCCACTGA GATGACTCCT ATGAATAGTC TGGGTAGATC CTCCCAGAGA 1620

AAGAAAACGG AGTCAGCTCT GTATGGGTGC ACCGTCCTTC TAGCATCGGT GGCTCTGGGA 1680

CTGGACCTCA GAGAGCTTGA TAAAGCACAG GCTGCTGAAG AACCGTTGCC CAAGGAAGAG 1740

AAGAAGAAAC GAGAGGGAAT CTTCCAGCGG GCTTCCAAGT CCCGCAGAAG CGCCAGTCCT 1800

CCCACAAGGC TGCTGTCCAC TGGTGGGGAG GCCAGCAGCC CACCCTCCCT GCCACTGACA 1860

AGTGTCCTGG GCATCCTCTC CACGCCTTCT CTCTCCACAA AGTGCCTGCT GCAGATGGAC 1920

AGTGAAGATC CACTGGCGGG CAGTACACCT GTCACTTGTG ACTCTGAGAT GCTCACTCTG 1980

GATTTTTGTC CCACTGCTCC AGGAAGTGGT CATGAGCCAG CCCTCATGCC ACGACTTGAC 2040

ACTGATCGTA GTGTATCAAG AAACTTGCCA TCTTCCTTCC TAGAGCAGAC ATGTGGGAGT 2100

GTACCTTACT GGGCTTCTTC AAAACATAGA CCGTCACATC ACAGACGGAC CATGTCTGAT 2160

GGGAATCCAA CCCCAACTGG TGCAACTATT ATCTCAGCCA CTGGAGCCTC TGCACTGCCA 2220

CTCTGCCCCT CACTTTATCC TCACAGTCAT CTGCCAAGGG AGGTCTCACC CAAGAAGCAC 2280

AGCACTGTCC ACATGATGCT TCAGCCTCGC CCTGCCTCCC TGAGAAGCCG CTCAGATCCG 2340

CCTCAGGCTT ACCCACAGAC AGCAGTGTCT CAGCTGGCAC AGACTGCCTG TGTAGTGGGT 2400

CGCCCAGGAC CACATCCCAC CCAATTCCTC GCTGCCAAGG AGAGAACTAA ATCCCATGTG 2460

CCTTCATTAC TGGATGCTGA CGTGGAAGGT CAGAGCAGGG ACTACACTGT GCCACTGTGC 2520

AGAATGAGGA GCAAAACCAG CCGGCCATCT ATATATGAAC TGGAGAAAGA ATTCCTGTCT 2580

TAA 2583

Domain Profile

S: 52    klshpniiellGvcleepnlllvmeyveggsLsnvlhe............kskreidlev  99

         +l+hpniiel+Gvcl++p+l+lv+e+++gg+L+++l++            ++ r+i+++v

Q: 1     MLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAanaapdprapgpRRARRIPPHV  60

         589**********************************999**********9*********

S: 100   lvswalqiArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarel  152

         lv+wa+qiArGm YLh+ea ++i+hrdLks+n+Ll       +  +ktlki+dFG are+

Q: 61    LVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLlekiehdDICNKTLKITDFGLAREW  120

         ***************************************999999***************

S: 153   skstkmsaagtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykv  212

         +++tkmsaagt+awmaPEv+k++ +s+ sD+wSygv+LWellt+evPy++++ la+ay+v

Q: 121   HRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV  180

         ************************************************************

S: 213   alkglrlpipsscpeklkkLmkecwnedpekRpsfseivksl  254

         a+++l+lpips+cpe+++kLmkecw++dp+ Rpsf+ i+++l

Q: 181   AVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILEQL  222

         **************************************9986

Domain Sequence
(FASTA)

MLRHPNIIEL RGVCLQQPHL CLVLEFARGG ALNRALAAAN AAPDPRAPGP RRARRIPPHV 60

LVNWAVQIAR GMLYLHEEAF VPILHRDLKS SNILLLEKIE HDDICNKTLK ITDFGLAREW 120

HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 180

AVNKLTLPIP STCPEPFAKL MKECWEQDPH IRPSFALILE QL 222

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013