EKS-NOL-00241

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00241

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.2	1.1E-128	82	334	253

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003101

UniProt Accession

G1QQ83;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000002471	ENSNLEP00000003101	ENSNLET00000003258

Organism

Nomascus leucogenys

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MELLRTITYQ PAASTKMCDQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAAPHHHH 60

HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 120

PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 180

EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 240

CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 300

SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA 360

KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEDIYKLRH DLKKTSITQQ PSKHRTDEEL 420

QPPTTTVARS GTPAAENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 480

GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 540

KKTVHYYAEL GQCSVFPTTD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDVRRPRL 600

YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 660

LMSGCSLELK NRMEYALNML LQRCN 685

Nucleotide Sequence
(FASTA)

ATGGAGCTTT TGCGGACTAT CACCTACCAG CCAGCCGCCA GCACCAAAAT GTGCGATCAG 60

GCGCTGGGCA AGGGTTGCGG AGCGGACTCG AAAAAGAAGC GGCCGCCGCA GCCCCCCGAG 120

GAATCGCAGC CACCTCAGTC CCAGGCGCAA GTGCCCCCGG CGGCCCCGCA TCACCATCAC 180

CACCATTCGC ACTCGGGGCC GGAGATCTCG CGGATTATCG TCGACCCCAC GACGGGGAAG 240

CGCTACTGCC GGGGCAAAGT GCTGGGAAAG GGTGGCTTTG CAAAATGTTA CGAGATGACA 300

GATTTGACAA ATAACAAAGT CTACGCCGCA AAAATTATTC CCCACAGCAG AGTAGCTAAA 360

CCTCATCAAA GGGAAAAGAT TGACAAAGAA ATAGAGCTTC ACAGAATTCT TCATCATAAG 420

CATGTAGTGC AGTTTTACCA CTACTTTGAG GACAAAGAAA ACATTTACAT TCTCTTGGAA 480

TACTGCAGTA GAAGGTCAAT GGCTCATATT TTGAAAGCAA GAAAGGTGTT GACAGAGCCA 540

GAAGTTCGAT ACTACCTCAG GCAGATTGTG TCTGGACTGA AATACCTTCA TGAACAAGAA 600

ATCTTGCACA GAGATCTCAA ACTAGGGAAC TTTTTTATTA ATGAAGCCAT GGAACTAAAA 660

GTTGGGGACT TCGGTCTGGC AGCCAGGCTA GAACCCTTGG AACACAGAAG GAGAACGATA 720

TGTGGTACCC CAAATTATCT CTCTCCGGAA GTCCTCAACA AACAAGGACA TGGCTGTGAA 780

TCAGACATTT GGGCCCTGGG CTGTGTAATG TATACAATGT TACTAGGGAG GCCCCCATTT 840

GAAACTACAA ATCTCAAAGA AACTTATAGG TGCATAAGGG AAGCAAGGTA TACAATGCCG 900

TCCTCATTGC TGGCTCCTGC CAAGCACTTA ATTGCTAGTA TGTTGTCCAA AAACCCAGAG 960

GATCGTCCCA GTTTGGATGA CATCATTCGA CATGACTTTT TTTTGCAGGG CTTCACTCCG 1020

GACAGACTGT CTTCTAGCTG TTGTCATACA GTTCCAGATT TCCACTTATC AAGCCCAGCT 1080

AAGAATTTCT TTAAGAAAGC AGCTGCTGCT CTTTTTGGTG GCAAAAAAGA CAAAGCAAGA 1140

TATATTGACA CACATAATAG AGTATCTAAA GAAGATGAAG ACATCTACAA GCTTAGGCAT 1200

GATTTGAAAA AGACTTCGAT AACTCAGCAA CCCAGCAAAC ACAGGACAGA TGAGGAGCTC 1260

CAGCCACCTA CCACCACAGT TGCCAGGTCT GGAACACCCG CAGCAGAAAA CAAGCAGCAG 1320

ATTGGGGATG CTATTCGGAT GATAGTCAGA GGGACTCTTG GCAGCTGCAG CAGCAGCAGT 1380

GAATGCCTTG AAGACAGTAC TATGGGAAGT GTTGCAGACA CAGTGGCAAG GGTTCTTCGG 1440

GGATGTCTGG AAAACATGCC AGAAGCTGAT TGCATTCCCA AAGAGCAGCT GAGCACATCA 1500

TTTCAGTGGG TCACCAAATG GGTTGATTAC TCTAACAAAT ATGGCTTTGG GTACCAGCTC 1560

TCTGACCACA CCGTTGGTGT CCTTTTCAAC AATGGTGCTC ACATGAGCCT CCTTCCAGAC 1620

AAAAAAACAG TTCACTATTA CGCAGAGCTT GGCCAATGCT CAGTTTTCCC AACAACAGAT 1680

GCTCCTGAGC AATTTATTAG TCAAGTGACG GTGCTGAAAT ACTTTTCTCA TTACATGGAG 1740

GAGAACCTCA TGGATGGTGG AGATCTGCCT AGTGTTACTG ATGTTCGAAG ACCTCGGCTC 1800

TACCTCCTTC AGTGGCTAAA ATCTGACAAG GCCCTAATGA TGCTCTTTAA TGATGGCACC 1860

TTTCAGGTGA ATTTCTACCA TGATCATACA AAAATAATCA TCTGTAGCCA AAATGAAGAA 1920

TACCTTCTCA CTTACATCAA TGAGGATAGG ATATCTACAA CTTTCAGGCT GACAACTCTG 1980

CTGATGTCTG GCTGTTCATT AGAATTAAAA AATCGAATGG AATATGCCCT GAACATGCTC 2040

TTACAAAGAT GTAACTGA 2058

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 82    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  141

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 142   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  201

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 202   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  261

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 262   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  321

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+++++++f+

Q: 322   RPSLDDIIRHDFF  334

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007052	; P:mitotic spindle organization
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599	; P:regulation of centriole replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013