EKS-NOL-00297

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00297

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	326.8	9.2E-98	410	658	249

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003370

UniProt Accession

G1QR02;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK6

Gene Synonyms/Alias

PAK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000002732	ENSNLEP00000003370	ENSNLET00000003536

Organism

Nomascus leucogenys

Functional Description

Protein Length

681

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT 60

RVQLQPMKTV VRGSAVPVDG YISGLLNDIQ KLSVISSNTL RGRSPTSRRR AQSLGLLGDE 120

HWATDPDMYL QSPQSERTDP HSLYLSCNGG APAGHRQMPW PEPQSPRVLP NGLAAKAQSL 180

GPTEFQGASQ RCLQLGACLQ SSPPGASPPT ATNRRGMKAA KHGSEEARPQ SCLVGSATGR 240

PGGEGSPSPK TRESSLKRRL FRSMFLSTAA TAPPSSSKPG PPPQSKPNSS FRPPQKDNPP 300

SLVAKAQSLP SDQPVGTFSP LTTSDTSSPQ KSLRTAPATG QLPGRSSPAG SPRTWHAQIS 360

TSNLYLPQDP TVAKGALAGE DTGVVTHEQF KAALRMVVDQ GDPRLLLDSY VKIGEGSTGI 420

VCLAREKHSG RQVAIKMMDL RKQQRRELLF NEVVIMRDYQ HFNVVEMYKS YLVGEELWVL 480

MEFLQGGALT DIVSQVRMNE EQIATVCEAV LQALAYLHAQ GVIHRDIKSD SILLTLDGRV 540

KLSDFGFCAQ ISKDVPKRKS LVGTPYWMAP EVISRSLYAT EVDIWSLGIM VIEMVDGEPP 600

YFSDSPVQAM KRLRDSPPPK LKNSHKVSPV LRDFLERMLV RDPQERATAQ ELLDHPFLLQ 660

TGLPECLVPL IQLYRKQTST C 681

Nucleotide Sequence
(FASTA)

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCGG CGCCACAGAA CTTCCAGCAC 60

CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 120

CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 180

AGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGGTGCC TGTGGATGGC 240

TACATCTCAG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 300

CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 360

CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 420

CACAGCCTCT ACCTCAGCTG CAACGGGGGC GCACCAGCAG GTCACAGGCA GATGCCGTGG 480

CCCGAGCCGC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 540

GGCCCCACCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGCGC CTGCCTGCAG 600

AGCTCCCCGC CAGGAGCCTC GCCCCCCACG GCCACCAATA GGCGTGGAAT GAAGGCTGCC 660

AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACGGGCAGG 720

CCAGGTGGGG AAGGCAGCCC GAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 780

TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACGGCCCCCC CAAGCAGCAG CAAGCCAGGC 840

CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 900

AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 960

CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 1020

CAGCTTCCAG GCCGGTCTTC CCCAGCGGGT TCCCCCCGCA CCTGGCACGC CCAGATCAGC 1080

ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGCGCCCT GGCTGGTGAG 1140

GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 1200

GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 1260

GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCATCAAGAT GATGGACCTC 1320

AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 1380

CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 1440

ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GATGAATGAG 1500

GAGCAGATCG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCCCAG 1560

GGCGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCTTGC TGACCCTCGA TGGCAGGGTG 1620

AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 1680

CTGGTGGGCA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT ATATGCCACT 1740

GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTGGATGG GGAGCCACCG 1800

TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCGCCCAAG 1860

CTGAAAAACT CTCACAAGGT CTCCCCGGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 1920

CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 1980

ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 2040

TGCTGA 2046

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++vaik+++l+kq++ e+l++e+ ++++++h n+ve+++

Q: 410   YVKIGEGSTGIVCLAREKHSGRQVAIKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYK  469

         679*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ eelw++me+l+gG+l+d+v+   + +++Eeqia++++ vl+aL+ylH+++viHrd

Q: 470   SYLVGEELWVLMEFLQGGALTDIVS---QVRMNEEQIATVCEAVLQALAYLHAQGVIHRD  526

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++Di

Q: 527   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYATEVDI  584

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  +++ppklk+++k+s+ +++f+e++l ++p+

Q: 585   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQ  644

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 645   ERATAQELLDHPFL  658

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAIKMMD LRKQQRRELL FNEVVIMRDY QHFNVVEMYK 60

SYLVGEELWV LMEFLQGGAL TDIVSQVRMN EEQIATVCEA VLQALAYLHA QGVIHRDIKS 120

DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI 180

MVIEMVDGEP PYFSDSPVQA MKRLRDSPPP KLKNSHKVSP VLRDFLERML VRDPQERATA 240

QELLDHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013