EKS-NOL-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	444.8	6.4E-134	235	478	244

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003499

UniProt Accession

G1QRC1;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000002816	ENSNLEP00000003499	ENSNLET00000003672

Organism

Nomascus leucogenys

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

MAGRGSLVSW RAFHGCDSAK ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT 60

RPKPGELAFR KGDVVTILEA CDNKSWYRVK HHTSGQEGLL AAGALREREA LSTDPKLSLM 120

PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI 180

DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ 240

IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHKNLVR LLGVILHQGL 300

YIVMEHVSKG QPVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV 360

SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY 420

GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR 480

ELRSAGAPAS VSGDADGSTS PRSQEP 506

Nucleotide Sequence
(FASTA)

ATGGCAGGGC GAGGCTCTCT GGTTTCCTGG CGGGCATTTC ACGGCTGTGA TTCTGCTAAG 60

GAACTTCCCC GGGTGAGCCC CCGCTTCCTC CGAGCCTGGC ACCCCCCACC CGTCTCAGCC 120

AGGATGCCAA CGAGGCGCTG GGCCCCGGGC ACCCAGTGTA TCACCAAATG CGAGCACACC 180

CGCCCCAAGC CAGGGGAGCT GGCCTTCCGC AAGGGCGACG TGGTCACCAT CCTGGAGGCC 240

TGCGATAACA AGAGCTGGTA CCGCGTCAAG CACCACACCA GTGGACAGGA GGGGCTGCTG 300

GCAGCTGGGG CGCTGCGGGA GCGGGAGGCC CTCTCCACAG ACCCCAAGCT CAGTCTCATG 360

CCGTGGTTCC ACGGGAAGAT CTCGGGCCAG GAGGCTGTCC AGCAGCTGCA GCCACCCGAG 420

GACGGGCTGT TCCTGGTGCG GGAGTCCGCG CGCCACCCCG GCGACTACGT CCTGTGCGTG 480

AGCTTTGGCC GCGACGTCAT CCACTACCGC GTGCTGCACC GCGACGGCCA CCTCACGATC 540

GATGAGGCCG TGTTCTTCTG CAACCTCATG GACATGGTGG AGCATTACAG CAAGGACAAG 600

GGCGCTATCT GCACCAAGCT GGTGAGACCA AAGCGGAAAC ACGGGACCAA GTCGGCCGAG 660

GAGGAGCTGG CCAGGGCAGG CTGGTTACTG AACCTGCAGC ATTTGACATT GGGAGCGCAG 720

ATCGGAGAGG GAGAGTTTGG AGCCGTCCTG CAGGGTGAGT ACCTGGGGCA AAAGGTGGCC 780

GTGAAGAATA TCAAGTGCGA TGTGACGGCC CAGGCCTTCC TGGACGAGAC GGCCGTCATG 840

ACGAAGATGC AACACAAGAA CCTGGTGCGT CTCCTGGGCG TGATCCTGCA CCAGGGGCTG 900

TACATTGTCA TGGAGCACGT GAGCAAGGGG CAACCTGTGA ACTTTCTGCG GACCCGGGGC 960

CGAGCCCTCG TGAACACCGC TCAGCTCCTG CAGTTTTCTC TGCACGTGGC CGAGGGCATG 1020

GAGTACCTGG AGAGCAAGAA GCTTGTGCAC CGCGACCTGG CCGCCCGCAA CATCCTGGTC 1080

TCCGAGGACC TGGTGGCCAA GGTCAGCGAC TTTGGCCTGG CCAAAGCAGA ACGGAAGGGG 1140

CTGGACTCAA GCCGGCTGCC CGTCAAGTGG ACGGCGCCTG AGGCTCTTAA ACACGGGAAG 1200

TTCACCAGCA AGTCGGATGT CTGGAGTTTT GGGGTGCTGC TCTGGGAGGT CTTCTCATAT 1260

GGACGGGCTC CGTACCCTAA AATGTCACTG AAGGAGGTGT CGGAGGCCGT GGAGAAGGGG 1320

TACCGCATGG AGCCCCCTGA GGGCTGTCCA GGCCCCGTGC ACGTCCTCAT GAGCAGCTGC 1380

TGGGAGGCAG AGCCCGCCCG CCGGCCACCC TTCCGCAAGC TGGCCGAGAA GCTGGCCCGG 1440

GAGCTACGCA GTGCAGGCGC CCCAGCCTCC GTCTCAGGGG ACGCCGACGG CTCCACCTCG 1500

CCCCGAAGCC AGGAGCCC 1518

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lg++ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtk++h+nlv+llgv

Q: 235   LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHKNLVRLLGV  294

         6899********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e+v+kg+ v++lr+rgral++++qll+f+l+vaegmeyleskklvhrdl

Q: 295   ILHQ-GLYIVMEHVSKGQPVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL  353

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsedlvakvsdfglak+e+k+lds++lpvkwtapealk++kf++ksdvwsfg+l

Q: 354   AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVL  413

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fs+gr+pyp+++lk+v++avekgy+me+pegcp+ v+ lm+++we+e+a+rp+f+k

Q: 414   LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK  473

         ************************************************************

S: 241   lkekl  245

         l+ekl

Q: 474   LAEKL  478

         **997

Domain Sequence
(FASTA)

LTLGAQIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKMQ HKNLVRLLGV 60

ILHQGLYIVM EHVSKGQPVN FLRTRGRALV NTAQLLQFSL HVAEGMEYLE SKKLVHRDLA 120

ARNILVSEDL VAKVSDFGLA KAERKGLDSS RLPVKWTAPE ALKHGKFTSK SDVWSFGVLL 180

WEVFSYGRAP YPKMSLKEVS EAVEKGYRME PPEGCPGPVH VLMSSCWEAE PARRPPFRKL 240

AEKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013