EKS-NOL-00212

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00212

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	381.8	1.7E-114	283	578	296

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003720

UniProt Accession

G1QS02;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000003013	ENSNLEP00000003720	ENSNLET00000003905

Organism

Nomascus leucogenys

Functional Description

Protein Length

608

Protein Sequence
(FASTA)

MDSGWVSSTV LGSYGFSQPQ PGAPQALRSL ASLPTCARPT SPPSYLRLLL CSRASRPKRL 60

RTRAVLRQAR AHGRGTASRR SPPLSPPKGG LGLLRSRGGW GWGPSRLPIS LSREAGPRSC 120

GRPSPPPASW TPAAASASLR PPQRWRLARL SPSARRLPSA QARSAARPRP PRRRPGPRPQ 180

PRARVGADRS RPAPYGPRLE APPPPARGAP MLARRKPVLP ALTINPTIAE GPSPTSEGAS 240

EANLVDLQKK LEELELDEQQ KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ 300

HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM 360

DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI LVNSRGEIKL 420

CDFGVSGQLI DSMANSFVGT RSYMAPERLQ GTHYSVQSDI WSMGLSLVEL AIGRYPIPPP 480

DAKELETIFR PVVRRGKKGE PHKHVGSRPP GRPISGHGVD SRPAMAIFEL LDHIVNEPPP 540

KLPNGVFTPD FQEFVNKCLI KNPAERADLK MLTNHTFIKR SEVEEVDFAG WLCTLRLNQP 600

GTPTRTAV 608

Nucleotide Sequence
(FASTA)

ATGGACTCTG GGTGGGTCTC GTCCACTGTT CTGGGGTCTT ACGGGTTCTC TCAGCCCCAG 60

CCTGGGGCAC CACAGGCTCT CAGGAGTCTG GCTTCCCTGC CCACCTGTGC ACGACCAACA 120

TCCCCGCCTT CATACCTCCG TCTCCTTCTC TGCTCCCGCG CGTCACGGCC CAAGCGCTTG 180

CGCACACGCG CCGTGCTACG GCAAGCGAGA GCGCACGGTC GGGGCACCGC GTCGCGTCGG 240

TCTCCGCCTC TTTCCCCTCC GAAAGGCGGC CTCGGGCTGC TGCGCAGCCG CGGCGGCTGG 300

GGGTGGGGTC CATCGCGGCT CCCGATCTCG TTATCGCGAG AGGCCGGTCC GCGATCTTGT 360

GGCCGCCCCT CCCCTCCCCC TGCCTCTTGG ACTCCGGCTG CGGCGTCAGC CTCCCTCCGG 420

CCTCCGCAGC GGTGGCGGCT CGCTCGCCTC AGCCCCAGCG CCCGTCGGCT ACCCTCGGCC 480

CAGGCCCGCA GCGCCGCCCG CCCTCGGCCG CCCCGACGCC GGCCTGGGCC GCGGCCGCAG 540

CCCCGGGCTC GCGTAGGCGC CGATCGCTCC CGGCCCGCCC CCTATGGGCC CCGGCTAGAG 600

GCGCCGCCGC CGCCGGCCCG CGGAGCCCCG ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG 660

GCGCTCACCA TCAACCCTAC CATCGCCGAG GGCCCGTCCC CTACCAGCGA GGGCGCCTCC 720

GAGGCAAACC TGGTGGACCT GCAGAAGAAG CTGGAGGAGC TGGAACTTGA CGAGCAGCAG 780

AAGAAGCGGC TGGAAGCCTT TCTCACCCAG AAAGCCAAGG TCGGCGAACT CAAAGATGAT 840

GACTTCGAAA GGATCTCAGA GCTGGGCGCG GGCAACGGCG GGGTGGTCAC CAAAGTCCAG 900

CACAGACCCT CAGGCCTCAT CATGGCCAGG AAGCTGATCC ACCTCGAGAT CAAGCCGGCC 960

ATCCGGAACC AGATCATCCG TGAGCTGCAG GTCCTGCATG AGTGCAACTC GCCGTACATC 1020

GTGGGCTTCT ACGGGGCCTT CTACAGCGAC GGGGAGATCA GCATCTGCAT GGAGCACATG 1080

GATGGCGGCT CCCTGGACCA GGTGCTGAAA GAGGCCAAGA GGATTCCGGA GGAGATCCTG 1140

GGGAAAGTCA GCATCGCGGT TCTCCGGGGC TTGGCGTACC TCCGAGAGAA GCACCAGATC 1200

ATGCACCGAG ATGTGAAGCC CTCCAACATC CTCGTGAACT CTAGAGGGGA GATCAAGCTG 1260

TGTGACTTCG GGGTGAGCGG CCAGCTCATC GACTCCATGG CCAACTCATT CGTGGGCACG 1320

CGCTCCTACA TGGCTCCGGA GCGGTTGCAG GGCACACATT ACTCGGTGCA GTCGGACATC 1380

TGGAGCATGG GCCTGTCCCT GGTGGAGCTG GCCATCGGAA GGTACCCCAT CCCCCCGCCC 1440

GATGCCAAGG AGCTGGAGAC CATCTTTCGA CCCGTGGTTC GACGGGGGAA GAAAGGAGAG 1500

CCTCACAAGC ATGTGGGCTC GAGGCCCCCC GGGCGCCCCA TCAGCGGTCA CGGGGTGGAT 1560

AGCCGGCCCG CCATGGCCAT CTTTGAACTG CTGGACCATA TTGTGAACGA GCCGCCTCCT 1620

AAGCTGCCCA ATGGTGTGTT CACCCCCGAC TTCCAGGAGT TTGTCAATAA ATGCCTCATC 1680

AAGAACCCAG CGGAGCGGGC GGACCTGAAG ATGCTCACAA ACCACACTTT CATCAAGCGG 1740

TCAGAGGTGG AAGAAGTGGA TTTTGCCGGC TGGTTGTGTA CCCTGCGGCT GAACCAGCCC 1800

GGCACACCCA CGCGCACCGC CGTGTGA 1827

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 283   ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  341

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 342   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  397

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYmaPEr++g ++Ysv

Q: 398   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG-THYSV  456

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvela+gryp++++++

Q: 457   QSDIWSMGLSLVELAIGRYPIPPPDAkeletifrpvvrrgkkgephkhvgsrppgrpisg  516

         ***********************9999*********************************

S: 208   ..........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkha  257

                   i+ell+ ivne+ppklp+  f+++fqefv+kCl+k+++eR++lk+l++h+

Q: 517   hgvdsrpamaIFELLDHIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHT  576

         ************************************************************

S: 258   fi  259

fi

Q: 577   FI  578

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMAPERLQGT HYSVQSDIWS 180

MGLSLVELAI GRYPIPPPDA KELETIFRPV VRRGKKGEPH KHVGSRPPGR PISGHGVDSR 240

PAMAIFELLD HIVNEPPPKL PNGVFTPDFQ EFVNKCLIKN PAERADLKML TNHTFI 296

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005778	; C:peroxisomal membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013